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1Y97

The human TREX2 3' exonuclease structure suggests a mechanism for efficient non-processive DNA catalysis

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0004527molecular_functionexonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006259biological_processDNA metabolic process
A0006281biological_processDNA repair
A0006308biological_processDNA catabolic process
A0008296molecular_function3'-5'-DNA exonuclease activity
A0008311molecular_functiondouble-stranded DNA 3'-5' DNA exonuclease activity
A0008408molecular_function3'-5' exonuclease activity
A0042803molecular_functionprotein homodimerization activity
A0046872molecular_functionmetal ion binding
A0060090molecular_functionmolecular adaptor activity
B0000287molecular_functionmagnesium ion binding
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0004527molecular_functionexonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006259biological_processDNA metabolic process
B0006281biological_processDNA repair
B0006308biological_processDNA catabolic process
B0008296molecular_function3'-5'-DNA exonuclease activity
B0008311molecular_functiondouble-stranded DNA 3'-5' DNA exonuclease activity
B0008408molecular_function3'-5' exonuclease activity
B0042803molecular_functionprotein homodimerization activity
B0046872molecular_functionmetal ion binding
B0060090molecular_functionmolecular adaptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000250
ChainResidueDetails
ALEU145
BLEU145

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY79
AALA150
BGLY79
BALA150

221716

PDB entries from 2024-06-26

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