1XWF
K185N mutated S-adenosylhomocysteine hydrolase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001666 | biological_process | response to hypoxia |
A | 0002439 | biological_process | chronic inflammatory response to antigenic stimulus |
A | 0004013 | molecular_function | adenosylhomocysteinase activity |
A | 0005507 | molecular_function | copper ion binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0007584 | biological_process | response to nutrient |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019510 | biological_process | S-adenosylhomocysteine catabolic process |
A | 0030554 | molecular_function | adenyl nucleotide binding |
A | 0033353 | biological_process | S-adenosylmethionine cycle |
A | 0042470 | cellular_component | melanosome |
A | 0042745 | biological_process | circadian sleep/wake cycle |
A | 0042802 | molecular_function | identical protein binding |
A | 0051287 | molecular_function | NAD binding |
A | 0098604 | molecular_function | adenosylselenohomocysteinase activity |
B | 0001666 | biological_process | response to hypoxia |
B | 0002439 | biological_process | chronic inflammatory response to antigenic stimulus |
B | 0004013 | molecular_function | adenosylhomocysteinase activity |
B | 0005507 | molecular_function | copper ion binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0007584 | biological_process | response to nutrient |
B | 0016787 | molecular_function | hydrolase activity |
B | 0019510 | biological_process | S-adenosylhomocysteine catabolic process |
B | 0030554 | molecular_function | adenyl nucleotide binding |
B | 0033353 | biological_process | S-adenosylmethionine cycle |
B | 0042470 | cellular_component | melanosome |
B | 0042745 | biological_process | circadian sleep/wake cycle |
B | 0042802 | molecular_function | identical protein binding |
B | 0051287 | molecular_function | NAD binding |
B | 0098604 | molecular_function | adenosylselenohomocysteinase activity |
C | 0001666 | biological_process | response to hypoxia |
C | 0002439 | biological_process | chronic inflammatory response to antigenic stimulus |
C | 0004013 | molecular_function | adenosylhomocysteinase activity |
C | 0005507 | molecular_function | copper ion binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005783 | cellular_component | endoplasmic reticulum |
C | 0005829 | cellular_component | cytosol |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0007584 | biological_process | response to nutrient |
C | 0016787 | molecular_function | hydrolase activity |
C | 0019510 | biological_process | S-adenosylhomocysteine catabolic process |
C | 0030554 | molecular_function | adenyl nucleotide binding |
C | 0033353 | biological_process | S-adenosylmethionine cycle |
C | 0042470 | cellular_component | melanosome |
C | 0042745 | biological_process | circadian sleep/wake cycle |
C | 0042802 | molecular_function | identical protein binding |
C | 0051287 | molecular_function | NAD binding |
C | 0098604 | molecular_function | adenosylselenohomocysteinase activity |
D | 0001666 | biological_process | response to hypoxia |
D | 0002439 | biological_process | chronic inflammatory response to antigenic stimulus |
D | 0004013 | molecular_function | adenosylhomocysteinase activity |
D | 0005507 | molecular_function | copper ion binding |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005829 | cellular_component | cytosol |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0007584 | biological_process | response to nutrient |
D | 0016787 | molecular_function | hydrolase activity |
D | 0019510 | biological_process | S-adenosylhomocysteine catabolic process |
D | 0030554 | molecular_function | adenyl nucleotide binding |
D | 0033353 | biological_process | S-adenosylmethionine cycle |
D | 0042470 | cellular_component | melanosome |
D | 0042745 | biological_process | circadian sleep/wake cycle |
D | 0042802 | molecular_function | identical protein binding |
D | 0051287 | molecular_function | NAD binding |
D | 0098604 | molecular_function | adenosylselenohomocysteinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAD A 432 |
Chain | Residue |
A | THR157 |
A | ILE243 |
A | ASP244 |
A | ASN247 |
A | THR274 |
A | THR275 |
A | GLY276 |
A | CYS277 |
A | ILE280 |
A | ILE298 |
A | GLY299 |
A | ASP189 |
A | HIS300 |
A | LEU343 |
A | ASN345 |
A | HIS352 |
B | GLN412 |
B | LYS425 |
B | TYR429 |
A | ASN190 |
A | GLY219 |
A | GLY221 |
A | ASP222 |
A | VAL223 |
A | THR241 |
A | GLU242 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ADN A 433 |
Chain | Residue |
A | HIS54 |
A | THR56 |
A | GLU58 |
A | ASP130 |
A | GLU155 |
A | ASP189 |
A | HIS300 |
A | LEU343 |
A | LEU346 |
A | HIS352 |
A | MET357 |
A | PHE361 |
site_id | AC3 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE NAD B 432 |
Chain | Residue |
A | GLN412 |
A | LYS425 |
A | TYR429 |
B | THR157 |
B | ASP189 |
B | ASN190 |
B | GLY221 |
B | ASP222 |
B | VAL223 |
B | THR241 |
B | GLU242 |
B | ILE243 |
B | ASP244 |
B | ASN247 |
B | THR274 |
B | THR275 |
B | GLY276 |
B | CYS277 |
B | ILE280 |
B | ILE298 |
B | GLY299 |
B | HIS300 |
B | LEU343 |
B | ASN345 |
B | HIS352 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE ADN B 433 |
Chain | Residue |
B | LEU53 |
B | HIS54 |
B | THR56 |
B | GLU58 |
B | THR59 |
B | ASP130 |
B | GLU155 |
B | ASP189 |
B | HIS300 |
B | LEU343 |
B | LEU346 |
B | HIS352 |
B | MET357 |
site_id | AC5 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAD C 432 |
Chain | Residue |
C | HOH438 |
D | GLN412 |
D | LYS425 |
D | TYR429 |
C | THR157 |
C | ASP189 |
C | ASN190 |
C | GLY219 |
C | GLY221 |
C | ASP222 |
C | VAL223 |
C | THR241 |
C | GLU242 |
C | ILE243 |
C | ASP244 |
C | ASN247 |
C | THR274 |
C | THR275 |
C | GLY276 |
C | CYS277 |
C | ILE280 |
C | ILE298 |
C | GLY299 |
C | HIS300 |
C | LEU343 |
C | ASN345 |
C | HIS352 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ADN C 433 |
Chain | Residue |
C | HIS54 |
C | THR56 |
C | GLU58 |
C | ASP130 |
C | GLU155 |
C | ASP189 |
C | HIS300 |
C | LEU343 |
C | LEU346 |
C | HIS352 |
C | MET357 |
site_id | AC7 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAD D 432 |
Chain | Residue |
C | GLN412 |
C | LYS425 |
C | TYR429 |
D | THR157 |
D | ASP189 |
D | ASN190 |
D | GLY219 |
D | GLY221 |
D | ASP222 |
D | VAL223 |
D | THR241 |
D | GLU242 |
D | ILE243 |
D | ASP244 |
D | ASN247 |
D | THR274 |
D | THR275 |
D | GLY276 |
D | CYS277 |
D | ILE280 |
D | ILE298 |
D | GLY299 |
D | HIS300 |
D | LEU343 |
D | ASN345 |
D | HIS352 |
D | HOH435 |
site_id | AC8 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ADN D 433 |
Chain | Residue |
D | HIS54 |
D | THR56 |
D | GLU58 |
D | ASP130 |
D | GLU155 |
D | ASP189 |
D | LEU343 |
D | LEU346 |
D | GLY351 |
D | HIS352 |
D | MET357 |
Functional Information from PROSITE/UniProt
site_id | PS00738 |
Number of Residues | 15 |
Details | ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDhAAAAI |
Chain | Residue | Details |
A | SER77-ILE91 |
site_id | PS00739 |
Number of Residues | 17 |
Details | ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKvavVaGYGdVGKGc.A |
Chain | Residue | Details |
A | GLY212-ALA228 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11741948 |
Chain | Residue | Details |
A | VAL57 | |
A | THR156 | |
B | VAL57 | |
B | THR156 | |
C | VAL57 | |
C | THR156 | |
D | VAL57 | |
D | THR156 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11927587 |
Chain | Residue | Details |
A | GLY131 | |
B | GLY131 | |
C | GLY131 | |
D | GLY131 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10913437, ECO:0000269|PubMed:11741948, ECO:0000269|PubMed:11927587, ECO:0007744|PDB:1D4F, ECO:0007744|PDB:1K0U, ECO:0007744|PDB:1KY5, ECO:0007744|PDB:2H5L |
Chain | Residue | Details |
A | THR157 | |
B | THR157 | |
C | THR157 | |
D | THR157 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11741948, ECO:0000269|PubMed:11927587 |
Chain | Residue | Details |
A | SER186 | |
A | ASN190 | |
B | SER186 | |
B | ASN190 | |
C | SER186 | |
C | ASN190 | |
D | SER186 | |
D | ASN190 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10387078 |
Chain | Residue | Details |
A | ASP222 | |
A | ILE243 | |
B | ASP222 | |
B | ILE243 | |
C | ASP222 | |
C | ILE243 | |
D | ASP222 | |
D | ILE243 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10913437, ECO:0000269|PubMed:11741948, ECO:0000269|PubMed:11927587, ECO:0007744|PDB:1D4F, ECO:0007744|PDB:1K0U, ECO:0007744|PDB:1KY4, ECO:0007744|PDB:1XWF, ECO:0007744|PDB:2H5L |
Chain | Residue | Details |
A | ALA248 | |
B | ALA248 | |
C | ALA248 | |
D | ALA248 |
site_id | SWS_FT_FI7 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10387078, ECO:0000269|PubMed:10913437, ECO:0000269|PubMed:11741948, ECO:0000269|PubMed:11927587, ECO:0007744|PDB:1B3R, ECO:0007744|PDB:1D4F, ECO:0007744|PDB:1K0U, ECO:0007744|PDB:1KY4, ECO:0007744|PDB:1KY5, ECO:0007744|PDB:1XWF, ECO:0007744|PDB:2H5L |
Chain | Residue | Details |
A | GLY299 | |
D | GLY299 | |
D | LEU346 | |
D | ARG430 | |
A | LEU346 | |
A | ARG430 | |
B | GLY299 | |
B | LEU346 | |
B | ARG430 | |
C | GLY299 | |
C | LEU346 | |
C | ARG430 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10387078, ECO:0000269|PubMed:10913437, ECO:0000269|PubMed:11741948, ECO:0007744|PDB:1B3R, ECO:0007744|PDB:1D4F, ECO:0007744|PDB:1K0U, ECO:0007744|PDB:1XWF, ECO:0007744|PDB:2H5L |
Chain | Residue | Details |
A | PRO353 | |
B | PRO353 | |
C | PRO353 | |
D | PRO353 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10387078, ECO:0000269|PubMed:11741948, ECO:0000269|PubMed:11927587, ECO:0007744|PDB:1B3R, ECO:0007744|PDB:1K0U, ECO:0007744|PDB:1KY4, ECO:0007744|PDB:1KY5, ECO:0007744|PDB:1XWF, ECO:0007744|PDB:2H5L |
Chain | Residue | Details |
A | PRO426 | |
B | PRO426 | |
C | PRO426 | |
D | PRO426 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23526 |
Chain | Residue | Details |
A | VAL183 | |
B | VAL183 | |
C | VAL183 | |
D | VAL183 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P23526 |
Chain | Residue | Details |
A | SER186 | |
B | SER186 | |
C | SER186 | |
D | SER186 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P50247 |
Chain | Residue | Details |
A | GLY193 | |
B | GLY193 | |
C | GLY193 | |
D | GLY193 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 7 |
Details | Annotated By Reference To The Literature 1b3r |
Chain | Residue | Details |
A | HIS54 | |
A | ASN185 | |
A | ASP189 | |
A | HIS300 | |
A | ASP130 | |
A | CYS194 | |
A | ASN190 |
site_id | CSA2 |
Number of Residues | 7 |
Details | Annotated By Reference To The Literature 1b3r |
Chain | Residue | Details |
B | HIS54 | |
B | ASN185 | |
B | ASP189 | |
B | HIS300 | |
B | ASP130 | |
B | CYS194 | |
B | ASN190 |
site_id | CSA3 |
Number of Residues | 7 |
Details | Annotated By Reference To The Literature 1b3r |
Chain | Residue | Details |
C | HIS54 | |
C | ASN185 | |
C | ASP189 | |
C | HIS300 | |
C | ASP130 | |
C | CYS194 | |
C | ASN190 |
site_id | CSA4 |
Number of Residues | 7 |
Details | Annotated By Reference To The Literature 1b3r |
Chain | Residue | Details |
D | HIS54 | |
D | ASN185 | |
D | ASP189 | |
D | HIS300 | |
D | ASP130 | |
D | CYS194 | |
D | ASN190 |
site_id | MCSA1 |
Number of Residues | 14 |
Details | M-CSA 90 |
Chain | Residue | Details |
A | MET55 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
A | ARG195 | electrostatic stabiliser, polar/non-polar interaction |
A | PHE301 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | PRO353 | electrostatic stabiliser |
A | PHE361 | electrostatic stabiliser, hydrogen bond donor |
A | VAL365 | activator, electrostatic stabiliser |
A | CYS78 | electrostatic stabiliser |
A | THR83 | electrostatic stabiliser |
A | GLY131 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
A | THR156 | electrostatic stabiliser, proton acceptor, proton donor |
A | ASP181 | activator, electrostatic stabiliser |
A | SER186 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | ASN190 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
A | LEU191 | electrostatic stabiliser, hydrogen bond acceptor |
site_id | MCSA2 |
Number of Residues | 14 |
Details | M-CSA 90 |
Chain | Residue | Details |
B | MET55 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
B | ARG195 | electrostatic stabiliser, polar/non-polar interaction |
B | PHE301 | activator, electrostatic stabiliser, hydrogen bond acceptor |
B | PRO353 | electrostatic stabiliser |
B | PHE361 | electrostatic stabiliser, hydrogen bond donor |
B | VAL365 | activator, electrostatic stabiliser |
B | CYS78 | electrostatic stabiliser |
B | THR83 | electrostatic stabiliser |
B | GLY131 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
B | THR156 | electrostatic stabiliser, proton acceptor, proton donor |
B | ASP181 | activator, electrostatic stabiliser |
B | SER186 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | ASN190 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
B | LEU191 | electrostatic stabiliser, hydrogen bond acceptor |
site_id | MCSA3 |
Number of Residues | 14 |
Details | M-CSA 90 |
Chain | Residue | Details |
C | MET55 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
C | ARG195 | electrostatic stabiliser, polar/non-polar interaction |
C | PHE301 | activator, electrostatic stabiliser, hydrogen bond acceptor |
C | PRO353 | electrostatic stabiliser |
C | PHE361 | electrostatic stabiliser, hydrogen bond donor |
C | VAL365 | activator, electrostatic stabiliser |
C | CYS78 | electrostatic stabiliser |
C | THR83 | electrostatic stabiliser |
C | GLY131 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
C | THR156 | electrostatic stabiliser, proton acceptor, proton donor |
C | ASP181 | activator, electrostatic stabiliser |
C | SER186 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
C | ASN190 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
C | LEU191 | electrostatic stabiliser, hydrogen bond acceptor |
site_id | MCSA4 |
Number of Residues | 14 |
Details | M-CSA 90 |
Chain | Residue | Details |
D | MET55 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
D | ARG195 | electrostatic stabiliser, polar/non-polar interaction |
D | PHE301 | activator, electrostatic stabiliser, hydrogen bond acceptor |
D | PRO353 | electrostatic stabiliser |
D | PHE361 | electrostatic stabiliser, hydrogen bond donor |
D | VAL365 | activator, electrostatic stabiliser |
D | CYS78 | electrostatic stabiliser |
D | THR83 | electrostatic stabiliser |
D | GLY131 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
D | THR156 | electrostatic stabiliser, proton acceptor, proton donor |
D | ASP181 | activator, electrostatic stabiliser |
D | SER186 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
D | ASN190 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
D | LEU191 | electrostatic stabiliser, hydrogen bond acceptor |