1WPL

Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0008217	biological_process	regulation of blood pressure
A	0008270	molecular_function	zinc ion binding
A	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
A	0030742	molecular_function	GTP-dependent protein binding
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0032991	cellular_component	protein-containing complex
A	0042311	biological_process	vasodilation
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0042802	molecular_function	identical protein binding
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0045776	biological_process	negative regulation of blood pressure
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0048265	biological_process	response to pain
A	0051066	biological_process	dihydrobiopterin metabolic process
A	0065003	biological_process	protein-containing complex assembly
A	0140535	cellular_component	intracellular protein-containing complex
A	2000773	biological_process	negative regulation of cellular senescence
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0008217	biological_process	regulation of blood pressure
B	0008270	molecular_function	zinc ion binding
B	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
B	0030742	molecular_function	GTP-dependent protein binding
B	0032212	biological_process	positive regulation of telomere maintenance via telomerase
B	0032991	cellular_component	protein-containing complex
B	0042311	biological_process	vasodilation
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0042802	molecular_function	identical protein binding
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0044877	molecular_function	protein-containing complex binding
B	0045776	biological_process	negative regulation of blood pressure
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0048265	biological_process	response to pain
B	0051066	biological_process	dihydrobiopterin metabolic process
B	0065003	biological_process	protein-containing complex assembly
B	0140535	cellular_component	intracellular protein-containing complex
B	2000773	biological_process	negative regulation of cellular senescence
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0008217	biological_process	regulation of blood pressure
C	0008270	molecular_function	zinc ion binding
C	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
C	0030742	molecular_function	GTP-dependent protein binding
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0032991	cellular_component	protein-containing complex
C	0042311	biological_process	vasodilation
C	0042558	biological_process	pteridine-containing compound metabolic process
C	0042802	molecular_function	identical protein binding
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0044877	molecular_function	protein-containing complex binding
C	0045776	biological_process	negative regulation of blood pressure
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0048265	biological_process	response to pain
C	0051066	biological_process	dihydrobiopterin metabolic process
C	0065003	biological_process	protein-containing complex assembly
C	0140535	cellular_component	intracellular protein-containing complex
C	2000773	biological_process	negative regulation of cellular senescence
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0008217	biological_process	regulation of blood pressure
D	0008270	molecular_function	zinc ion binding
D	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
D	0030742	molecular_function	GTP-dependent protein binding
D	0032212	biological_process	positive regulation of telomere maintenance via telomerase
D	0032991	cellular_component	protein-containing complex
D	0042311	biological_process	vasodilation
D	0042558	biological_process	pteridine-containing compound metabolic process
D	0042802	molecular_function	identical protein binding
D	0043525	biological_process	positive regulation of neuron apoptotic process
D	0044877	molecular_function	protein-containing complex binding
D	0045776	biological_process	negative regulation of blood pressure
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0048265	biological_process	response to pain
D	0051066	biological_process	dihydrobiopterin metabolic process
D	0065003	biological_process	protein-containing complex assembly
D	0140535	cellular_component	intracellular protein-containing complex
D	2000773	biological_process	negative regulation of cellular senescence
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0008217	biological_process	regulation of blood pressure
E	0008270	molecular_function	zinc ion binding
E	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
E	0030742	molecular_function	GTP-dependent protein binding
E	0032212	biological_process	positive regulation of telomere maintenance via telomerase
E	0032991	cellular_component	protein-containing complex
E	0042311	biological_process	vasodilation
E	0042558	biological_process	pteridine-containing compound metabolic process
E	0042802	molecular_function	identical protein binding
E	0043525	biological_process	positive regulation of neuron apoptotic process
E	0044877	molecular_function	protein-containing complex binding
E	0045776	biological_process	negative regulation of blood pressure
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0048265	biological_process	response to pain
E	0051066	biological_process	dihydrobiopterin metabolic process
E	0065003	biological_process	protein-containing complex assembly
E	0140535	cellular_component	intracellular protein-containing complex
E	2000773	biological_process	negative regulation of cellular senescence
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0008217	biological_process	regulation of blood pressure
F	0008270	molecular_function	zinc ion binding
F	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
F	0030742	molecular_function	GTP-dependent protein binding
F	0032212	biological_process	positive regulation of telomere maintenance via telomerase
F	0032991	cellular_component	protein-containing complex
F	0042311	biological_process	vasodilation
F	0042558	biological_process	pteridine-containing compound metabolic process
F	0042802	molecular_function	identical protein binding
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0044877	molecular_function	protein-containing complex binding
F	0045776	biological_process	negative regulation of blood pressure
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0048265	biological_process	response to pain
F	0051066	biological_process	dihydrobiopterin metabolic process
F	0065003	biological_process	protein-containing complex assembly
F	0140535	cellular_component	intracellular protein-containing complex
F	2000773	biological_process	negative regulation of cellular senescence
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0008217	biological_process	regulation of blood pressure
G	0008270	molecular_function	zinc ion binding
G	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
G	0030742	molecular_function	GTP-dependent protein binding
G	0032212	biological_process	positive regulation of telomere maintenance via telomerase
G	0032991	cellular_component	protein-containing complex
G	0042311	biological_process	vasodilation
G	0042558	biological_process	pteridine-containing compound metabolic process
G	0042802	molecular_function	identical protein binding
G	0043525	biological_process	positive regulation of neuron apoptotic process
G	0044877	molecular_function	protein-containing complex binding
G	0045776	biological_process	negative regulation of blood pressure
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0048265	biological_process	response to pain
G	0051066	biological_process	dihydrobiopterin metabolic process
G	0065003	biological_process	protein-containing complex assembly
G	0140535	cellular_component	intracellular protein-containing complex
G	2000773	biological_process	negative regulation of cellular senescence
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0008217	biological_process	regulation of blood pressure
H	0008270	molecular_function	zinc ion binding
H	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
H	0030742	molecular_function	GTP-dependent protein binding
H	0032212	biological_process	positive regulation of telomere maintenance via telomerase
H	0032991	cellular_component	protein-containing complex
H	0042311	biological_process	vasodilation
H	0042558	biological_process	pteridine-containing compound metabolic process
H	0042802	molecular_function	identical protein binding
H	0043525	biological_process	positive regulation of neuron apoptotic process
H	0044877	molecular_function	protein-containing complex binding
H	0045776	biological_process	negative regulation of blood pressure
H	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0048265	biological_process	response to pain
H	0051066	biological_process	dihydrobiopterin metabolic process
H	0065003	biological_process	protein-containing complex assembly
H	0140535	cellular_component	intracellular protein-containing complex
H	2000773	biological_process	negative regulation of cellular senescence
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0006729	biological_process	tetrahydrobiopterin biosynthetic process
I	0008217	biological_process	regulation of blood pressure
I	0008270	molecular_function	zinc ion binding
I	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
I	0030742	molecular_function	GTP-dependent protein binding
I	0032212	biological_process	positive regulation of telomere maintenance via telomerase
I	0032991	cellular_component	protein-containing complex
I	0042311	biological_process	vasodilation
I	0042558	biological_process	pteridine-containing compound metabolic process
I	0042802	molecular_function	identical protein binding
I	0043525	biological_process	positive regulation of neuron apoptotic process
I	0044877	molecular_function	protein-containing complex binding
I	0045776	biological_process	negative regulation of blood pressure
I	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0048265	biological_process	response to pain
I	0051066	biological_process	dihydrobiopterin metabolic process
I	0065003	biological_process	protein-containing complex assembly
I	0140535	cellular_component	intracellular protein-containing complex
I	2000773	biological_process	negative regulation of cellular senescence
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0006729	biological_process	tetrahydrobiopterin biosynthetic process
J	0008217	biological_process	regulation of blood pressure
J	0008270	molecular_function	zinc ion binding
J	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
J	0030742	molecular_function	GTP-dependent protein binding
J	0032212	biological_process	positive regulation of telomere maintenance via telomerase
J	0032991	cellular_component	protein-containing complex
J	0042311	biological_process	vasodilation
J	0042558	biological_process	pteridine-containing compound metabolic process
J	0042802	molecular_function	identical protein binding
J	0043525	biological_process	positive regulation of neuron apoptotic process
J	0044877	molecular_function	protein-containing complex binding
J	0045776	biological_process	negative regulation of blood pressure
J	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0048265	biological_process	response to pain
J	0051066	biological_process	dihydrobiopterin metabolic process
J	0065003	biological_process	protein-containing complex assembly
J	0140535	cellular_component	intracellular protein-containing complex
J	2000773	biological_process	negative regulation of cellular senescence
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009890	biological_process	negative regulation of biosynthetic process
K	0016597	molecular_function	amino acid binding
K	0030742	molecular_function	GTP-dependent protein binding
K	0031965	cellular_component	nuclear membrane
K	0032991	cellular_component	protein-containing complex
K	0042802	molecular_function	identical protein binding
K	0044549	molecular_function	GTP cyclohydrolase binding
K	0044877	molecular_function	protein-containing complex binding
K	0060308	molecular_function	GTP cyclohydrolase I regulator activity
K	0065003	biological_process	protein-containing complex assembly
K	0140535	cellular_component	intracellular protein-containing complex
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009890	biological_process	negative regulation of biosynthetic process
L	0016597	molecular_function	amino acid binding
L	0030742	molecular_function	GTP-dependent protein binding
L	0031965	cellular_component	nuclear membrane
L	0032991	cellular_component	protein-containing complex
L	0042802	molecular_function	identical protein binding
L	0044549	molecular_function	GTP cyclohydrolase binding
L	0044877	molecular_function	protein-containing complex binding
L	0060308	molecular_function	GTP cyclohydrolase I regulator activity
L	0065003	biological_process	protein-containing complex assembly
L	0140535	cellular_component	intracellular protein-containing complex
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0009890	biological_process	negative regulation of biosynthetic process
M	0016597	molecular_function	amino acid binding
M	0030742	molecular_function	GTP-dependent protein binding
M	0031965	cellular_component	nuclear membrane
M	0032991	cellular_component	protein-containing complex
M	0042802	molecular_function	identical protein binding
M	0044549	molecular_function	GTP cyclohydrolase binding
M	0044877	molecular_function	protein-containing complex binding
M	0060308	molecular_function	GTP cyclohydrolase I regulator activity
M	0065003	biological_process	protein-containing complex assembly
M	0140535	cellular_component	intracellular protein-containing complex
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0009890	biological_process	negative regulation of biosynthetic process
N	0016597	molecular_function	amino acid binding
N	0030742	molecular_function	GTP-dependent protein binding
N	0031965	cellular_component	nuclear membrane
N	0032991	cellular_component	protein-containing complex
N	0042802	molecular_function	identical protein binding
N	0044549	molecular_function	GTP cyclohydrolase binding
N	0044877	molecular_function	protein-containing complex binding
N	0060308	molecular_function	GTP cyclohydrolase I regulator activity
N	0065003	biological_process	protein-containing complex assembly
N	0140535	cellular_component	intracellular protein-containing complex
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0009890	biological_process	negative regulation of biosynthetic process
O	0016597	molecular_function	amino acid binding
O	0030742	molecular_function	GTP-dependent protein binding
O	0031965	cellular_component	nuclear membrane
O	0032991	cellular_component	protein-containing complex
O	0042802	molecular_function	identical protein binding
O	0044549	molecular_function	GTP cyclohydrolase binding
O	0044877	molecular_function	protein-containing complex binding
O	0060308	molecular_function	GTP cyclohydrolase I regulator activity
O	0065003	biological_process	protein-containing complex assembly
O	0140535	cellular_component	intracellular protein-containing complex
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0009890	biological_process	negative regulation of biosynthetic process
P	0016597	molecular_function	amino acid binding
P	0030742	molecular_function	GTP-dependent protein binding
P	0031965	cellular_component	nuclear membrane
P	0032991	cellular_component	protein-containing complex
P	0042802	molecular_function	identical protein binding
P	0044549	molecular_function	GTP cyclohydrolase binding
P	0044877	molecular_function	protein-containing complex binding
P	0060308	molecular_function	GTP cyclohydrolase I regulator activity
P	0065003	biological_process	protein-containing complex assembly
P	0140535	cellular_component	intracellular protein-containing complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0009890	biological_process	negative regulation of biosynthetic process
Q	0016597	molecular_function	amino acid binding
Q	0030742	molecular_function	GTP-dependent protein binding
Q	0031965	cellular_component	nuclear membrane
Q	0032991	cellular_component	protein-containing complex
Q	0042802	molecular_function	identical protein binding
Q	0044549	molecular_function	GTP cyclohydrolase binding
Q	0044877	molecular_function	protein-containing complex binding
Q	0060308	molecular_function	GTP cyclohydrolase I regulator activity
Q	0065003	biological_process	protein-containing complex assembly
Q	0140535	cellular_component	intracellular protein-containing complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0009890	biological_process	negative regulation of biosynthetic process
R	0016597	molecular_function	amino acid binding
R	0030742	molecular_function	GTP-dependent protein binding
R	0031965	cellular_component	nuclear membrane
R	0032991	cellular_component	protein-containing complex
R	0042802	molecular_function	identical protein binding
R	0044549	molecular_function	GTP cyclohydrolase binding
R	0044877	molecular_function	protein-containing complex binding
R	0060308	molecular_function	GTP cyclohydrolase I regulator activity
R	0065003	biological_process	protein-containing complex assembly
R	0140535	cellular_component	intracellular protein-containing complex
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0009890	biological_process	negative regulation of biosynthetic process
S	0016597	molecular_function	amino acid binding
S	0030742	molecular_function	GTP-dependent protein binding
S	0031965	cellular_component	nuclear membrane
S	0032991	cellular_component	protein-containing complex
S	0042802	molecular_function	identical protein binding
S	0044549	molecular_function	GTP cyclohydrolase binding
S	0044877	molecular_function	protein-containing complex binding
S	0060308	molecular_function	GTP cyclohydrolase I regulator activity
S	0065003	biological_process	protein-containing complex assembly
S	0140535	cellular_component	intracellular protein-containing complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0009890	biological_process	negative regulation of biosynthetic process
T	0016597	molecular_function	amino acid binding
T	0030742	molecular_function	GTP-dependent protein binding
T	0031965	cellular_component	nuclear membrane
T	0032991	cellular_component	protein-containing complex
T	0042802	molecular_function	identical protein binding
T	0044549	molecular_function	GTP cyclohydrolase binding
T	0044877	molecular_function	protein-containing complex binding
T	0060308	molecular_function	GTP cyclohydrolase I regulator activity
T	0065003	biological_process	protein-containing complex assembly
T	0140535	cellular_component	intracellular protein-containing complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA L 1011

Chain	Residue
L	THR8
L	GLN9
L	ARG11
L	VAL14
L	GLY15

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA M 1012

Chain	Residue
M	GLY15
M	THR8
M	GLN9
M	ARG11
M	VAL14

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA N 1013

Chain	Residue
N	THR8
N	GLN9
N	ARG11
N	VAL14
N	GLY15
N	PRO16

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA O 1014

Chain	Residue
O	THR8
O	GLN9
O	ARG11
O	VAL14
O	GLY15

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA K 1015

Chain	Residue
K	THR8
K	GLN9
K	ARG11
K	VAL14
K	GLY15

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA T 1016

Chain	Residue
T	THR8
T	GLN9
T	ARG11
T	VAL14
T	GLY15

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA P 1017

Chain	Residue
P	THR8
P	GLN9
P	ARG11
P	VAL14
P	GLY15

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA Q 1018

Chain	Residue
Q	THR8
Q	GLN9
Q	ARG11
Q	VAL14

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA R 1019

Chain	Residue
R	THR8
R	GLN9
R	ARG11
R	VAL14
R	GLY15

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA S 1020

Chain	Residue
S	THR8
S	GLN9
S	ARG11
S	VAL14
S	GLY15

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN G 1101

Chain	Residue
G	CYS132
G	HIS135
G	CYS203

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E 1102

Chain	Residue
E	CYS132
E	HIS135
E	CYS203

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 1103

Chain	Residue
C	CYS132
C	HIS135
C	CYS203

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 1104

Chain	Residue
D	CYS132
D	HIS135
D	CYS203

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1105

Chain	Residue
F	CYS132
F	HIS135
F	CYS203
F	HOH2023

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN J 1106

Chain	Residue
J	CYS132
J	HIS135
J	CYS203

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN H 1107

Chain	Residue
H	CYS132
H	HIS135
H	CYS203

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 1108

Chain	Residue
B	CYS132
B	HIS135
B	CYS203

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 1109

Chain	Residue
I	CYS132
I	HIS135
I	CYS203
J	HOH2016

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 1110

Chain	Residue
A	CYS132
A	HIS135
A	CYS203

---

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HBI C 1001

Chain	Residue
C	SER219
C	MET221
C	ARG226
C	ARG232
C	HOH2003
C	HOH2014
D	ASP118
D	MET120
D	VAL224
D	THR231
D	GLU234
N	ILE10

---

site_id	CC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HBI D 1002

Chain	Residue
E	ASP118
E	THR231
E	GLU234
E	HOH2007
O	GLN9
D	SER219
D	MET221
D	ARG226
D	ARG232
D	HOH2006

---

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HBI A 1003

Chain	Residue
A	ASP118
A	THR231
A	GLU234
E	SER219
E	MET221
E	ARG226
E	ARG232
E	HOH2013
K	GLN9

---

site_id	CC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HBI A 1004

Chain	Residue
A	SER219
A	MET221
A	ARG226
A	ARG232
A	HOH2006
B	ASP118
B	THR231
B	GLU234
B	HOH2010
L	GLN9

---

site_id	CC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HBI B 1005

Chain	Residue
B	SER219
B	MET221
B	ARG226
B	ARG232
B	HOH2011
C	ASP118
C	THR231
C	GLU234
M	GLN9
M	ILE10

---

site_id	CC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HBI G 1006

Chain	Residue
G	SER219
G	MET221
G	ARG226
G	ARG232
G	HOH2010
H	ASP118
H	LEU148
H	THR231
H	GLU234
H	HOH2013
R	GLN9

---

site_id	CC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HBI H 1007

Chain	Residue
H	SER219
H	MET221
H	ARG226
H	ARG232
H	HOH2014
I	ASP118
I	THR231
I	GLU234
I	HOH2009
S	GLN9
S	ILE10

---

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HBI I 1008

Chain	Residue
I	SER219
I	MET221
I	ARG226
I	ARG232
I	HOH2013
J	ASP118
J	THR231
J	GLU234
J	HOH2012
T	ILE10

---

site_id	DC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HBI F 1009

Chain	Residue
F	ASP118
F	MET120
F	LEU148
F	THR231
F	GLU234
F	HOH2015
F	HOH2021
F	HOH2022
J	SER219
J	MET221
J	ARG226
J	ARG232

---

site_id	DC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HBI F 1010

Chain	Residue
F	SER219
F	MET221
F	ARG226
F	ARG232
F	HOH2011
F	HOH2019
F	HOH2020
G	ASP118
G	LEU148
G	THR231
G	GLU234
Q	GLN9

---

site_id	DC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3PO B 2001

Chain	Residue
A	HIS135
A	ARG207
A	GLY208
B	SER157
B	LYS158
B	ARG161
J	LYS84
J	ARG88

---

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3PO C 2002

Chain	Residue
B	HIS135
B	ARG207
C	SER157
C	LYS158
C	ARG161
I	LYS84
I	ARG88

---

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3PO D 2003

Chain	Residue
C	HIS135
C	ARG207
D	SER157
D	LYS158
D	ARG161
H	LYS84
H	ARG88

---

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 3PO E 2004

Chain	Residue
D	HIS135
D	ARG207
E	SER157
E	LYS158
E	ARG161
G	ARG88

---

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 3PO A 2005

Chain	Residue
A	SER157
A	LYS158
A	ARG161
E	HIS135
E	ARG207
F	ARG88

---

site_id	DC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3PO G 2006

Chain	Residue
E	LYS84
E	ARG88
F	HIS135
F	ARG207
G	SER157
G	LYS158
G	ARG161

---

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3PO H 2007

Chain	Residue
D	LYS84
D	ARG88
G	HIS135
G	ARG207
H	SER157
H	LYS158
H	ARG161

---

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3PO I 2008

Chain	Residue
C	LYS84
C	ARG88
H	HIS135
H	ARG207
I	SER157
I	LYS158
I	ARG161

---

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 3PO J 2009

Chain	Residue
B	LYS84
B	ARG88
I	HIS135
I	ARG207
J	SER157
J	LYS158
J	ARG161

---

site_id	EC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3PO F 2010

Chain	Residue
A	LYS84
A	ARG88
F	SER157
F	LYS158
F	ARG161
J	HIS135
J	ARG207
J	GLY208

---

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU119-HIS135

---

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER167-THR177

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30793","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Site: {"description":"Involved in pterin ring binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P30793","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
A	HIS201
A	HIS134

---

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
J	HIS201
J	HIS134

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
B	HIS201
B	HIS134

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
C	HIS201
C	HIS134

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
D	HIS201
D	HIS134

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
E	HIS201
E	HIS134

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
F	HIS201
F	HIS134

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
G	HIS201
G	HIS134

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
H	HIS201
H	HIS134

---

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
I	HIS201
I	HIS134

---