1WAO

PP5 structure

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000165	biological_process	MAPK cascade
1	0000278	biological_process	mitotic cell cycle
1	0001965	molecular_function	G-protein alpha-subunit binding
1	0003723	molecular_function	RNA binding
1	0004721	molecular_function	phosphoprotein phosphatase activity
1	0004722	molecular_function	protein serine/threonine phosphatase activity
1	0005515	molecular_function	protein binding
1	0005524	molecular_function	ATP binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005886	cellular_component	plasma membrane
1	0006281	biological_process	DNA repair
1	0006302	biological_process	double-strand break repair
1	0006351	biological_process	DNA-templated transcription
1	0006974	biological_process	DNA damage response
1	0008017	molecular_function	microtubule binding
1	0008289	molecular_function	lipid binding
1	0010288	biological_process	response to lead ion
1	0016787	molecular_function	hydrolase activity
1	0016791	molecular_function	phosphatase activity
1	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
1	0030544	molecular_function	Hsp70 protein binding
1	0031072	molecular_function	heat shock protein binding
1	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
1	0032991	cellular_component	protein-containing complex
1	0042802	molecular_function	identical protein binding
1	0043025	cellular_component	neuronal cell body
1	0043066	biological_process	negative regulation of apoptotic process
1	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
1	0043204	cellular_component	perikaryon
1	0043409	biological_process	negative regulation of MAPK cascade
1	0043531	molecular_function	ADP binding
1	0044877	molecular_function	protein-containing complex binding
1	0046872	molecular_function	metal ion binding
1	0048156	molecular_function	tau protein binding
1	0051879	molecular_function	Hsp90 protein binding
1	0070262	biological_process	peptidyl-serine dephosphorylation
1	0070301	biological_process	cellular response to hydrogen peroxide
1	0071276	biological_process	cellular response to cadmium ion
1	0101031	cellular_component	protein folding chaperone complex
1	1904550	biological_process	response to arachidonate
1	1990635	cellular_component	proximal dendrite
1	2000324	biological_process	positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway
2	0000165	biological_process	MAPK cascade
2	0000278	biological_process	mitotic cell cycle
2	0001965	molecular_function	G-protein alpha-subunit binding
2	0003723	molecular_function	RNA binding
2	0004721	molecular_function	phosphoprotein phosphatase activity
2	0004722	molecular_function	protein serine/threonine phosphatase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005886	cellular_component	plasma membrane
2	0006281	biological_process	DNA repair
2	0006302	biological_process	double-strand break repair
2	0006351	biological_process	DNA-templated transcription
2	0006974	biological_process	DNA damage response
2	0008017	molecular_function	microtubule binding
2	0008289	molecular_function	lipid binding
2	0010288	biological_process	response to lead ion
2	0016787	molecular_function	hydrolase activity
2	0016791	molecular_function	phosphatase activity
2	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
2	0030544	molecular_function	Hsp70 protein binding
2	0031072	molecular_function	heat shock protein binding
2	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
2	0032991	cellular_component	protein-containing complex
2	0042802	molecular_function	identical protein binding
2	0043025	cellular_component	neuronal cell body
2	0043066	biological_process	negative regulation of apoptotic process
2	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
2	0043204	cellular_component	perikaryon
2	0043409	biological_process	negative regulation of MAPK cascade
2	0043531	molecular_function	ADP binding
2	0044877	molecular_function	protein-containing complex binding
2	0046872	molecular_function	metal ion binding
2	0048156	molecular_function	tau protein binding
2	0051879	molecular_function	Hsp90 protein binding
2	0070262	biological_process	peptidyl-serine dephosphorylation
2	0070301	biological_process	cellular response to hydrogen peroxide
2	0071276	biological_process	cellular response to cadmium ion
2	0101031	cellular_component	protein folding chaperone complex
2	1904550	biological_process	response to arachidonate
2	1990635	cellular_component	proximal dendrite
2	2000324	biological_process	positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway
3	0000165	biological_process	MAPK cascade
3	0000278	biological_process	mitotic cell cycle
3	0001965	molecular_function	G-protein alpha-subunit binding
3	0003723	molecular_function	RNA binding
3	0004721	molecular_function	phosphoprotein phosphatase activity
3	0004722	molecular_function	protein serine/threonine phosphatase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005886	cellular_component	plasma membrane
3	0006281	biological_process	DNA repair
3	0006302	biological_process	double-strand break repair
3	0006351	biological_process	DNA-templated transcription
3	0006974	biological_process	DNA damage response
3	0008017	molecular_function	microtubule binding
3	0008289	molecular_function	lipid binding
3	0010288	biological_process	response to lead ion
3	0016787	molecular_function	hydrolase activity
3	0016791	molecular_function	phosphatase activity
3	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
3	0030544	molecular_function	Hsp70 protein binding
3	0031072	molecular_function	heat shock protein binding
3	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
3	0032991	cellular_component	protein-containing complex
3	0042802	molecular_function	identical protein binding
3	0043025	cellular_component	neuronal cell body
3	0043066	biological_process	negative regulation of apoptotic process
3	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
3	0043204	cellular_component	perikaryon
3	0043409	biological_process	negative regulation of MAPK cascade
3	0043531	molecular_function	ADP binding
3	0044877	molecular_function	protein-containing complex binding
3	0046872	molecular_function	metal ion binding
3	0048156	molecular_function	tau protein binding
3	0051879	molecular_function	Hsp90 protein binding
3	0070262	biological_process	peptidyl-serine dephosphorylation
3	0070301	biological_process	cellular response to hydrogen peroxide
3	0071276	biological_process	cellular response to cadmium ion
3	0101031	cellular_component	protein folding chaperone complex
3	1904550	biological_process	response to arachidonate
3	1990635	cellular_component	proximal dendrite
3	2000324	biological_process	positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway
4	0000165	biological_process	MAPK cascade
4	0000278	biological_process	mitotic cell cycle
4	0001965	molecular_function	G-protein alpha-subunit binding
4	0003723	molecular_function	RNA binding
4	0004721	molecular_function	phosphoprotein phosphatase activity
4	0004722	molecular_function	protein serine/threonine phosphatase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005737	cellular_component	cytoplasm
4	0005829	cellular_component	cytosol
4	0005886	cellular_component	plasma membrane
4	0006281	biological_process	DNA repair
4	0006302	biological_process	double-strand break repair
4	0006351	biological_process	DNA-templated transcription
4	0006974	biological_process	DNA damage response
4	0008017	molecular_function	microtubule binding
4	0008289	molecular_function	lipid binding
4	0010288	biological_process	response to lead ion
4	0016787	molecular_function	hydrolase activity
4	0016791	molecular_function	phosphatase activity
4	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
4	0030544	molecular_function	Hsp70 protein binding
4	0031072	molecular_function	heat shock protein binding
4	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
4	0032991	cellular_component	protein-containing complex
4	0042802	molecular_function	identical protein binding
4	0043025	cellular_component	neuronal cell body
4	0043066	biological_process	negative regulation of apoptotic process
4	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
4	0043204	cellular_component	perikaryon
4	0043409	biological_process	negative regulation of MAPK cascade
4	0043531	molecular_function	ADP binding
4	0044877	molecular_function	protein-containing complex binding
4	0046872	molecular_function	metal ion binding
4	0048156	molecular_function	tau protein binding
4	0051879	molecular_function	Hsp90 protein binding
4	0070262	biological_process	peptidyl-serine dephosphorylation
4	0070301	biological_process	cellular response to hydrogen peroxide
4	0071276	biological_process	cellular response to cadmium ion
4	0101031	cellular_component	protein folding chaperone complex
4	1904550	biological_process	response to arachidonate
4	1990635	cellular_component	proximal dendrite
4	2000324	biological_process	positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN 1 601

Chain	Residue
1	ASP271
1	ASN303
1	HIS352
1	HIS427
1	MN602

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN 1 602

Chain	Residue
1	MN601
1	ASP242
1	HIS244
1	ASP271
1	TYR451

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 2 601

Chain	Residue
2	ASP242
2	ASP271
2	ASN303
2	HIS352
2	HIS427
2	MN602

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN 2 602

Chain	Residue
2	ASP242
2	HIS244
2	ASP271
2	MN601

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 3 601

Chain	Residue
3	ASP242
3	ASP271
3	ASN303
3	HIS352
3	HIS427
3	MN602

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN 3 602

Chain	Residue
3	ASP242
3	HIS244
3	ASP271
3	TYR451
3	MN601

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 4 601

Chain	Residue
4	ASP242
4	ASP271
4	ASN303
4	HIS352
4	HIS427
4	MN602

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 4 602

Chain	Residue
4	GLU76
4	ASP242
4	HIS244
4	ASP271
4	ARG275
4	MN601

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
1	LEU300-GLU305

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	132
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	630
Details	Region: {"description":"Catalytic"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Region: {"description":"Required for autoinhibition","evidences":[{"source":"UniProtKB","id":"P53042","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15577939","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19601647","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H64","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
1	HIS304
1	ASP274

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
2	HIS304
2	ASP274

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
3	HIS304
3	ASP274

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
4	HIS304
4	ASP274

---

site_id	MCSA1
Number of Residues	10
Details	M-CSA 472

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	10
Details	M-CSA 472

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues	10
Details	M-CSA 472

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues	10
Details	M-CSA 472

Chain

Residue

Details

---