1WAO

PP5 structure

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000165	biological_process	MAPK cascade
1	0000278	biological_process	mitotic cell cycle
1	0003723	molecular_function	RNA binding
1	0004721	molecular_function	phosphoprotein phosphatase activity
1	0004722	molecular_function	protein serine/threonine phosphatase activity
1	0005515	molecular_function	protein binding
1	0005524	molecular_function	ATP binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005886	cellular_component	plasma membrane
1	0006281	biological_process	DNA repair
1	0006302	biological_process	double-strand break repair
1	0006351	biological_process	DNA-templated transcription
1	0006470	biological_process	protein dephosphorylation
1	0006974	biological_process	DNA damage response
1	0008289	molecular_function	lipid binding
1	0010288	biological_process	response to lead ion
1	0016020	cellular_component	membrane
1	0016787	molecular_function	hydrolase activity
1	0016791	molecular_function	phosphatase activity
1	0017018	molecular_function	myosin phosphatase activity
1	0032991	cellular_component	protein-containing complex
1	0035970	biological_process	peptidyl-threonine dephosphorylation
1	0042802	molecular_function	identical protein binding
1	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
1	0043231	cellular_component	intracellular membrane-bounded organelle
1	0043278	biological_process	response to morphine
1	0043531	molecular_function	ADP binding
1	0046872	molecular_function	metal ion binding
1	0048156	molecular_function	tau protein binding
1	0051879	molecular_function	Hsp90 protein binding
1	0070262	biological_process	peptidyl-serine dephosphorylation
1	0101031	cellular_component	protein folding chaperone complex
1	1904550	biological_process	response to arachidonic acid
2	0000165	biological_process	MAPK cascade
2	0000278	biological_process	mitotic cell cycle
2	0003723	molecular_function	RNA binding
2	0004721	molecular_function	phosphoprotein phosphatase activity
2	0004722	molecular_function	protein serine/threonine phosphatase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005886	cellular_component	plasma membrane
2	0006281	biological_process	DNA repair
2	0006302	biological_process	double-strand break repair
2	0006351	biological_process	DNA-templated transcription
2	0006470	biological_process	protein dephosphorylation
2	0006974	biological_process	DNA damage response
2	0008289	molecular_function	lipid binding
2	0010288	biological_process	response to lead ion
2	0016020	cellular_component	membrane
2	0016787	molecular_function	hydrolase activity
2	0016791	molecular_function	phosphatase activity
2	0017018	molecular_function	myosin phosphatase activity
2	0032991	cellular_component	protein-containing complex
2	0035970	biological_process	peptidyl-threonine dephosphorylation
2	0042802	molecular_function	identical protein binding
2	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
2	0043231	cellular_component	intracellular membrane-bounded organelle
2	0043278	biological_process	response to morphine
2	0043531	molecular_function	ADP binding
2	0046872	molecular_function	metal ion binding
2	0048156	molecular_function	tau protein binding
2	0051879	molecular_function	Hsp90 protein binding
2	0070262	biological_process	peptidyl-serine dephosphorylation
2	0101031	cellular_component	protein folding chaperone complex
2	1904550	biological_process	response to arachidonic acid
3	0000165	biological_process	MAPK cascade
3	0000278	biological_process	mitotic cell cycle
3	0003723	molecular_function	RNA binding
3	0004721	molecular_function	phosphoprotein phosphatase activity
3	0004722	molecular_function	protein serine/threonine phosphatase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005886	cellular_component	plasma membrane
3	0006281	biological_process	DNA repair
3	0006302	biological_process	double-strand break repair
3	0006351	biological_process	DNA-templated transcription
3	0006470	biological_process	protein dephosphorylation
3	0006974	biological_process	DNA damage response
3	0008289	molecular_function	lipid binding
3	0010288	biological_process	response to lead ion
3	0016020	cellular_component	membrane
3	0016787	molecular_function	hydrolase activity
3	0016791	molecular_function	phosphatase activity
3	0017018	molecular_function	myosin phosphatase activity
3	0032991	cellular_component	protein-containing complex
3	0035970	biological_process	peptidyl-threonine dephosphorylation
3	0042802	molecular_function	identical protein binding
3	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
3	0043231	cellular_component	intracellular membrane-bounded organelle
3	0043278	biological_process	response to morphine
3	0043531	molecular_function	ADP binding
3	0046872	molecular_function	metal ion binding
3	0048156	molecular_function	tau protein binding
3	0051879	molecular_function	Hsp90 protein binding
3	0070262	biological_process	peptidyl-serine dephosphorylation
3	0101031	cellular_component	protein folding chaperone complex
3	1904550	biological_process	response to arachidonic acid
4	0000165	biological_process	MAPK cascade
4	0000278	biological_process	mitotic cell cycle
4	0003723	molecular_function	RNA binding
4	0004721	molecular_function	phosphoprotein phosphatase activity
4	0004722	molecular_function	protein serine/threonine phosphatase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005737	cellular_component	cytoplasm
4	0005829	cellular_component	cytosol
4	0005886	cellular_component	plasma membrane
4	0006281	biological_process	DNA repair
4	0006302	biological_process	double-strand break repair
4	0006351	biological_process	DNA-templated transcription
4	0006470	biological_process	protein dephosphorylation
4	0006974	biological_process	DNA damage response
4	0008289	molecular_function	lipid binding
4	0010288	biological_process	response to lead ion
4	0016020	cellular_component	membrane
4	0016787	molecular_function	hydrolase activity
4	0016791	molecular_function	phosphatase activity
4	0017018	molecular_function	myosin phosphatase activity
4	0032991	cellular_component	protein-containing complex
4	0035970	biological_process	peptidyl-threonine dephosphorylation
4	0042802	molecular_function	identical protein binding
4	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
4	0043231	cellular_component	intracellular membrane-bounded organelle
4	0043278	biological_process	response to morphine
4	0043531	molecular_function	ADP binding
4	0046872	molecular_function	metal ion binding
4	0048156	molecular_function	tau protein binding
4	0051879	molecular_function	Hsp90 protein binding
4	0070262	biological_process	peptidyl-serine dephosphorylation
4	0101031	cellular_component	protein folding chaperone complex
4	1904550	biological_process	response to arachidonic acid

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN 1 601

Chain	Residue
1	ASP271
1	ASN303
1	HIS352
1	HIS427
1	MN602

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN 1 602

Chain	Residue
1	MN601
1	ASP242
1	HIS244
1	ASP271
1	TYR451

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 2 601

Chain	Residue
2	ASP242
2	ASP271
2	ASN303
2	HIS352
2	HIS427
2	MN602

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN 2 602

Chain	Residue
2	ASP242
2	HIS244
2	ASP271
2	MN601

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 3 601

Chain	Residue
3	ASP242
3	ASP271
3	ASN303
3	HIS352
3	HIS427
3	MN602

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN 3 602

Chain	Residue
3	ASP242
3	HIS244
3	ASP271
3	TYR451
3	MN601

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 4 601

Chain	Residue
4	ASP242
4	ASP271
4	ASN303
4	HIS352
4	HIS427
4	MN602

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN 4 602

Chain	Residue
4	GLU76
4	ASP242
4	HIS244
4	ASP271
4	ARG275
4	MN601

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
1	LEU300-GLU305

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:15155720

Chain	Residue	Details
1	HIS304
2	HIS304
3	HIS304
4	HIS304

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64

Chain	Residue	Details
1	ASP242
2	ASP242
2	ASP271
2	ASN303
2	HIS352
3	ASP242
3	ASP271
3	ASN303
3	HIS352
4	ASP242
4	ASP271
4	ASN303
4	HIS352
1	ASP271
1	ASN303
1	HIS352

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:15155720

Chain	Residue	Details
1	HIS244
2	HIS244
2	ARG275
2	ARG400
2	HIS427
3	HIS244
3	ARG275
3	ARG400
3	HIS427
4	HIS244
4	ARG275
4	ARG400
4	HIS427
1	ARG275
1	ARG400
1	HIS427

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
1	ASP242	metal ligand
1	HIS244	metal ligand
1	ASP271	metal ligand
1	ASP274	activator, proton donor
1	ARG275	transition state stabiliser
1	ASN303	metal ligand, transition state stabiliser
1	HIS304	proton acceptor, proton donor, proton relay
1	HIS352	metal ligand
1	ARG400	transition state stabiliser
1	HIS427	activator, metal ligand

---

site_id	MCSA2
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
2	ASP242	metal ligand
2	HIS244	metal ligand
2	ASP271	metal ligand
2	ASP274	activator, proton donor
2	ARG275	transition state stabiliser
2	ASN303	metal ligand, transition state stabiliser
2	HIS304	proton acceptor, proton donor, proton relay
2	HIS352	metal ligand
2	ARG400	transition state stabiliser
2	HIS427	activator, metal ligand

---

site_id	MCSA3
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
3	ASP242	metal ligand
3	HIS244	metal ligand
3	ASP271	metal ligand
3	ASP274	activator, proton donor
3	ARG275	transition state stabiliser
3	ASN303	metal ligand, transition state stabiliser
3	HIS304	proton acceptor, proton donor, proton relay
3	HIS352	metal ligand
3	ARG400	transition state stabiliser
3	HIS427	activator, metal ligand

---

site_id	MCSA4
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
4	ASP242	metal ligand
4	HIS244	metal ligand
4	ASP271	metal ligand
4	ASP274	activator, proton donor
4	ARG275	transition state stabiliser
4	ASN303	metal ligand, transition state stabiliser
4	HIS304	proton acceptor, proton donor, proton relay
4	HIS352	metal ligand
4	ARG400	transition state stabiliser
4	HIS427	activator, metal ligand

---