1W7K

E.coli FolC in complex with ADP, without folate substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004326	molecular_function	tetrahydrofolylpolyglutamate synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006730	biological_process	one-carbon metabolic process
A	0006761	biological_process	dihydrofolate biosynthetic process
A	0008841	molecular_function	dihydrofolate synthase activity
A	0009058	biological_process	biosynthetic process
A	0009257	biological_process	10-formyltetrahydrofolate biosynthetic process
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016874	molecular_function	ligase activity
A	0016881	molecular_function	acid-amino acid ligase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0046901	biological_process	tetrahydrofolylpolyglutamate biosynthetic process
A	0097216	molecular_function	guanosine tetraphosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SO4 A 1422

Chain	Residue
A	LYS60
A	HOH2215
A	HOH2428
A	HOH2434
A	HOH2435
A	SER83
A	GLU146
A	HIS305
A	ADP1421
A	MG1423
A	MG1424
A	HOH2052
A	HOH2083

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1423

Chain	Residue
A	SER83
A	GLU146
A	ADP1421
A	SO41422
A	HOH2180
A	HOH2428

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1424

Chain	Residue
A	HIS173
A	SO41422
A	HOH2051
A	HOH2215
A	HOH2237
A	HOH2434

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 1421

Chain	Residue
A	THR57
A	ASN58
A	GLY59
A	LYS60
A	GLY61
A	THR62
A	GLU146
A	ASN257
A	GLY288
A	ARG289
A	ASP302
A	ALA304
A	HIS308
A	ALA309
A	TYR312
A	SO41422
A	MG1423
A	HOH2052
A	HOH2428
A	HOH2429
A	HOH2430
A	HOH2433

---

Functional Information from PROSITE/UniProt

site_id	PS01011
Number of Residues	24
Details	FOLYLPOLYGLU_SYNT_1 Folylpolyglutamate synthase signature 1. FtVAGTNGKgTtcrtLeSILmaa.G

Chain	Residue	Details
A	PHE52-GLY75

---

site_id	PS01012
Number of Residues	16
Details	FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. ILEvGLGGrlDaTnIV

Chain	Residue	Details
A	ILE144-VAL159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15705579","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1W78","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15705579","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1W78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W7K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15705579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"15705579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1p3d

Chain	Residue	Details
A	LYS60

---