1W63

AP1 clathrin adaptor core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030121	cellular_component	AP-1 adaptor complex
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
C	0005794	cellular_component	Golgi apparatus
C	0006886	biological_process	intracellular protein transport
C	0016192	biological_process	vesicle-mediated transport
C	0030117	cellular_component	membrane coat
C	0030121	cellular_component	AP-1 adaptor complex
D	0006886	biological_process	intracellular protein transport
D	0015031	biological_process	protein transport
D	0016192	biological_process	vesicle-mediated transport
D	0030117	cellular_component	membrane coat
D	0030276	molecular_function	clathrin binding
E	0005794	cellular_component	Golgi apparatus
E	0006886	biological_process	intracellular protein transport
E	0016192	biological_process	vesicle-mediated transport
E	0030117	cellular_component	membrane coat
E	0030121	cellular_component	AP-1 adaptor complex
F	0006886	biological_process	intracellular protein transport
F	0015031	biological_process	protein transport
F	0016192	biological_process	vesicle-mediated transport
F	0030117	cellular_component	membrane coat
F	0030276	molecular_function	clathrin binding
G	0005794	cellular_component	Golgi apparatus
G	0006886	biological_process	intracellular protein transport
G	0016192	biological_process	vesicle-mediated transport
G	0030117	cellular_component	membrane coat
G	0030121	cellular_component	AP-1 adaptor complex
H	0006886	biological_process	intracellular protein transport
H	0015031	biological_process	protein transport
H	0016192	biological_process	vesicle-mediated transport
H	0030117	cellular_component	membrane coat
H	0030276	molecular_function	clathrin binding
I	0005794	cellular_component	Golgi apparatus
I	0006886	biological_process	intracellular protein transport
I	0016192	biological_process	vesicle-mediated transport
I	0030117	cellular_component	membrane coat
I	0030121	cellular_component	AP-1 adaptor complex
J	0006886	biological_process	intracellular protein transport
J	0015031	biological_process	protein transport
J	0016192	biological_process	vesicle-mediated transport
J	0030117	cellular_component	membrane coat
J	0030276	molecular_function	clathrin binding
K	0005794	cellular_component	Golgi apparatus
K	0006886	biological_process	intracellular protein transport
K	0016192	biological_process	vesicle-mediated transport
K	0030117	cellular_component	membrane coat
K	0030121	cellular_component	AP-1 adaptor complex
L	0006886	biological_process	intracellular protein transport
L	0015031	biological_process	protein transport
L	0016192	biological_process	vesicle-mediated transport
L	0030117	cellular_component	membrane coat
L	0030276	molecular_function	clathrin binding
M	0005515	molecular_function	protein binding
M	0005765	cellular_component	lysosomal membrane
M	0005769	cellular_component	early endosome
M	0005794	cellular_component	Golgi apparatus
M	0005802	cellular_component	trans-Golgi network
M	0005829	cellular_component	cytosol
M	0006886	biological_process	intracellular protein transport
M	0006896	biological_process	Golgi to vacuole transport
M	0015031	biological_process	protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0030121	cellular_component	AP-1 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0032438	biological_process	melanosome organization
M	0032588	cellular_component	trans-Golgi network membrane
M	0035615	molecular_function	clathrin adaptor activity
M	0035646	biological_process	endosome to melanosome transport
M	0045202	cellular_component	synapse
M	0060155	biological_process	platelet dense granule organization
M	1903232	biological_process	melanosome assembly
N	0005515	molecular_function	protein binding
N	0005765	cellular_component	lysosomal membrane
N	0005769	cellular_component	early endosome
N	0005794	cellular_component	Golgi apparatus
N	0005802	cellular_component	trans-Golgi network
N	0005829	cellular_component	cytosol
N	0006886	biological_process	intracellular protein transport
N	0006896	biological_process	Golgi to vacuole transport
N	0015031	biological_process	protein transport
N	0016192	biological_process	vesicle-mediated transport
N	0030121	cellular_component	AP-1 adaptor complex
N	0030131	cellular_component	clathrin adaptor complex
N	0030665	cellular_component	clathrin-coated vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0032438	biological_process	melanosome organization
N	0032588	cellular_component	trans-Golgi network membrane
N	0035615	molecular_function	clathrin adaptor activity
N	0035646	biological_process	endosome to melanosome transport
N	0045202	cellular_component	synapse
N	0060155	biological_process	platelet dense granule organization
N	1903232	biological_process	melanosome assembly
O	0005515	molecular_function	protein binding
O	0005765	cellular_component	lysosomal membrane
O	0005769	cellular_component	early endosome
O	0005794	cellular_component	Golgi apparatus
O	0005802	cellular_component	trans-Golgi network
O	0005829	cellular_component	cytosol
O	0006886	biological_process	intracellular protein transport
O	0006896	biological_process	Golgi to vacuole transport
O	0015031	biological_process	protein transport
O	0016192	biological_process	vesicle-mediated transport
O	0030121	cellular_component	AP-1 adaptor complex
O	0030131	cellular_component	clathrin adaptor complex
O	0030665	cellular_component	clathrin-coated vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0032438	biological_process	melanosome organization
O	0032588	cellular_component	trans-Golgi network membrane
O	0035615	molecular_function	clathrin adaptor activity
O	0035646	biological_process	endosome to melanosome transport
O	0045202	cellular_component	synapse
O	0060155	biological_process	platelet dense granule organization
O	1903232	biological_process	melanosome assembly
P	0005515	molecular_function	protein binding
P	0005765	cellular_component	lysosomal membrane
P	0005769	cellular_component	early endosome
P	0005794	cellular_component	Golgi apparatus
P	0005802	cellular_component	trans-Golgi network
P	0005829	cellular_component	cytosol
P	0006886	biological_process	intracellular protein transport
P	0006896	biological_process	Golgi to vacuole transport
P	0015031	biological_process	protein transport
P	0016192	biological_process	vesicle-mediated transport
P	0030121	cellular_component	AP-1 adaptor complex
P	0030131	cellular_component	clathrin adaptor complex
P	0030665	cellular_component	clathrin-coated vesicle membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0032438	biological_process	melanosome organization
P	0032588	cellular_component	trans-Golgi network membrane
P	0035615	molecular_function	clathrin adaptor activity
P	0035646	biological_process	endosome to melanosome transport
P	0045202	cellular_component	synapse
P	0060155	biological_process	platelet dense granule organization
P	1903232	biological_process	melanosome assembly
Q	0005515	molecular_function	protein binding
Q	0005765	cellular_component	lysosomal membrane
Q	0005769	cellular_component	early endosome
Q	0005794	cellular_component	Golgi apparatus
Q	0005802	cellular_component	trans-Golgi network
Q	0005829	cellular_component	cytosol
Q	0005905	cellular_component	clathrin-coated pit
Q	0006886	biological_process	intracellular protein transport
Q	0009615	biological_process	response to virus
Q	0015031	biological_process	protein transport
Q	0016192	biological_process	vesicle-mediated transport
Q	0030117	cellular_component	membrane coat
Q	0030121	cellular_component	AP-1 adaptor complex
Q	0030659	cellular_component	cytoplasmic vesicle membrane
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0032588	cellular_component	trans-Golgi network membrane
Q	0035615	molecular_function	clathrin adaptor activity
Q	0042147	biological_process	retrograde transport, endosome to Golgi
Q	0043195	cellular_component	terminal bouton
Q	0060155	biological_process	platelet dense granule organization
Q	0098793	cellular_component	presynapse
Q	0110010	biological_process	basolateral protein secretion
Q	1903232	biological_process	melanosome assembly
R	0005515	molecular_function	protein binding
R	0005765	cellular_component	lysosomal membrane
R	0005769	cellular_component	early endosome
R	0005794	cellular_component	Golgi apparatus
R	0005802	cellular_component	trans-Golgi network
R	0005829	cellular_component	cytosol
R	0006886	biological_process	intracellular protein transport
R	0006896	biological_process	Golgi to vacuole transport
R	0015031	biological_process	protein transport
R	0016192	biological_process	vesicle-mediated transport
R	0030121	cellular_component	AP-1 adaptor complex
R	0030131	cellular_component	clathrin adaptor complex
R	0030665	cellular_component	clathrin-coated vesicle membrane
R	0031410	cellular_component	cytoplasmic vesicle
R	0032438	biological_process	melanosome organization
R	0032588	cellular_component	trans-Golgi network membrane
R	0035615	molecular_function	clathrin adaptor activity
R	0035646	biological_process	endosome to melanosome transport
R	0045202	cellular_component	synapse
R	0060155	biological_process	platelet dense granule organization
R	1903232	biological_process	melanosome assembly
S	0005515	molecular_function	protein binding
S	0005765	cellular_component	lysosomal membrane
S	0005769	cellular_component	early endosome
S	0005794	cellular_component	Golgi apparatus
S	0005802	cellular_component	trans-Golgi network
S	0005829	cellular_component	cytosol
S	0005905	cellular_component	clathrin-coated pit
S	0006886	biological_process	intracellular protein transport
S	0009615	biological_process	response to virus
S	0015031	biological_process	protein transport
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030121	cellular_component	AP-1 adaptor complex
S	0030659	cellular_component	cytoplasmic vesicle membrane
S	0031410	cellular_component	cytoplasmic vesicle
S	0032588	cellular_component	trans-Golgi network membrane
S	0035615	molecular_function	clathrin adaptor activity
S	0042147	biological_process	retrograde transport, endosome to Golgi
S	0043195	cellular_component	terminal bouton
S	0060155	biological_process	platelet dense granule organization
S	0098793	cellular_component	presynapse
S	0110010	biological_process	basolateral protein secretion
S	1903232	biological_process	melanosome assembly
T	0005515	molecular_function	protein binding
T	0005765	cellular_component	lysosomal membrane
T	0005769	cellular_component	early endosome
T	0005794	cellular_component	Golgi apparatus
T	0005802	cellular_component	trans-Golgi network
T	0005829	cellular_component	cytosol
T	0005905	cellular_component	clathrin-coated pit
T	0006886	biological_process	intracellular protein transport
T	0009615	biological_process	response to virus
T	0015031	biological_process	protein transport
T	0016192	biological_process	vesicle-mediated transport
T	0030117	cellular_component	membrane coat
T	0030121	cellular_component	AP-1 adaptor complex
T	0030659	cellular_component	cytoplasmic vesicle membrane
T	0031410	cellular_component	cytoplasmic vesicle
T	0032588	cellular_component	trans-Golgi network membrane
T	0035615	molecular_function	clathrin adaptor activity
T	0042147	biological_process	retrograde transport, endosome to Golgi
T	0043195	cellular_component	terminal bouton
T	0060155	biological_process	platelet dense granule organization
T	0098793	cellular_component	presynapse
T	0110010	biological_process	basolateral protein secretion
T	1903232	biological_process	melanosome assembly
U	0005515	molecular_function	protein binding
U	0005765	cellular_component	lysosomal membrane
U	0005769	cellular_component	early endosome
U	0005794	cellular_component	Golgi apparatus
U	0005802	cellular_component	trans-Golgi network
U	0005829	cellular_component	cytosol
U	0005905	cellular_component	clathrin-coated pit
U	0006886	biological_process	intracellular protein transport
U	0009615	biological_process	response to virus
U	0015031	biological_process	protein transport
U	0016192	biological_process	vesicle-mediated transport
U	0030117	cellular_component	membrane coat
U	0030121	cellular_component	AP-1 adaptor complex
U	0030659	cellular_component	cytoplasmic vesicle membrane
U	0031410	cellular_component	cytoplasmic vesicle
U	0032588	cellular_component	trans-Golgi network membrane
U	0035615	molecular_function	clathrin adaptor activity
U	0042147	biological_process	retrograde transport, endosome to Golgi
U	0043195	cellular_component	terminal bouton
U	0060155	biological_process	platelet dense granule organization
U	0098793	cellular_component	presynapse
U	0110010	biological_process	basolateral protein secretion
U	1903232	biological_process	melanosome assembly
V	0005515	molecular_function	protein binding
V	0005765	cellular_component	lysosomal membrane
V	0005769	cellular_component	early endosome
V	0005794	cellular_component	Golgi apparatus
V	0005802	cellular_component	trans-Golgi network
V	0005829	cellular_component	cytosol
V	0006886	biological_process	intracellular protein transport
V	0006896	biological_process	Golgi to vacuole transport
V	0015031	biological_process	protein transport
V	0016192	biological_process	vesicle-mediated transport
V	0030121	cellular_component	AP-1 adaptor complex
V	0030131	cellular_component	clathrin adaptor complex
V	0030665	cellular_component	clathrin-coated vesicle membrane
V	0031410	cellular_component	cytoplasmic vesicle
V	0032438	biological_process	melanosome organization
V	0032588	cellular_component	trans-Golgi network membrane
V	0035615	molecular_function	clathrin adaptor activity
V	0035646	biological_process	endosome to melanosome transport
V	0045202	cellular_component	synapse
V	0060155	biological_process	platelet dense granule organization
V	1903232	biological_process	melanosome assembly
W	0005515	molecular_function	protein binding
W	0005765	cellular_component	lysosomal membrane
W	0005769	cellular_component	early endosome
W	0005794	cellular_component	Golgi apparatus
W	0005802	cellular_component	trans-Golgi network
W	0005829	cellular_component	cytosol
W	0005905	cellular_component	clathrin-coated pit
W	0006886	biological_process	intracellular protein transport
W	0009615	biological_process	response to virus
W	0015031	biological_process	protein transport
W	0016192	biological_process	vesicle-mediated transport
W	0030117	cellular_component	membrane coat
W	0030121	cellular_component	AP-1 adaptor complex
W	0030659	cellular_component	cytoplasmic vesicle membrane
W	0031410	cellular_component	cytoplasmic vesicle
W	0032588	cellular_component	trans-Golgi network membrane
W	0035615	molecular_function	clathrin adaptor activity
W	0042147	biological_process	retrograde transport, endosome to Golgi
W	0043195	cellular_component	terminal bouton
W	0060155	biological_process	platelet dense granule organization
W	0098793	cellular_component	presynapse
W	0110010	biological_process	basolateral protein secretion
W	1903232	biological_process	melanosome assembly
X	0005515	molecular_function	protein binding
X	0005765	cellular_component	lysosomal membrane
X	0005769	cellular_component	early endosome
X	0005794	cellular_component	Golgi apparatus
X	0005802	cellular_component	trans-Golgi network
X	0005829	cellular_component	cytosol
X	0005905	cellular_component	clathrin-coated pit
X	0006886	biological_process	intracellular protein transport
X	0009615	biological_process	response to virus
X	0015031	biological_process	protein transport
X	0016192	biological_process	vesicle-mediated transport
X	0030117	cellular_component	membrane coat
X	0030121	cellular_component	AP-1 adaptor complex
X	0030659	cellular_component	cytoplasmic vesicle membrane
X	0031410	cellular_component	cytoplasmic vesicle
X	0032588	cellular_component	trans-Golgi network membrane
X	0035615	molecular_function	clathrin adaptor activity
X	0042147	biological_process	retrograde transport, endosome to Golgi
X	0043195	cellular_component	terminal bouton
X	0060155	biological_process	platelet dense granule organization
X	0098793	cellular_component	presynapse
X	0110010	biological_process	basolateral protein secretion
X	1903232	biological_process	melanosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. VVYKryasLYF

Chain	Residue	Details
Q	VAL57-PHE67

---

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. VSWRse.GikYrkNeVFLDVIE

Chain	Residue	Details
M	VAL157-GLU177

---

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY

Chain	Residue	Details
M	ILE253-TYR267

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q10567","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"O35643","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"UniProtKB","id":"Q9BXS5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---