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1VKJ

Crystal structure of heparan sulfate 3-O-sulfotransferase isoform 1 in the presence of PAP

Replaces:  1S6T
Functional Information from GO Data
ChainGOidnamespacecontents
A0005794cellular_componentGolgi apparatus
A0005796cellular_componentGolgi lumen
A0006024biological_processglycosaminoglycan biosynthetic process
A0008146molecular_functionsulfotransferase activity
A0008467molecular_function[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
A0015012biological_processheparan sulfate proteoglycan biosynthetic process
A0016740molecular_functiontransferase activity
B0005794cellular_componentGolgi apparatus
B0005796cellular_componentGolgi lumen
B0006024biological_processglycosaminoglycan biosynthetic process
B0008146molecular_functionsulfotransferase activity
B0008467molecular_function[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
B0015012biological_processheparan sulfate proteoglycan biosynthetic process
B0016740molecular_functiontransferase activity
C0005794cellular_componentGolgi apparatus
C0005796cellular_componentGolgi lumen
C0006024biological_processglycosaminoglycan biosynthetic process
C0008146molecular_functionsulfotransferase activity
C0008467molecular_function[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
C0015012biological_processheparan sulfate proteoglycan biosynthetic process
C0016740molecular_functiontransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 601
ChainResidue
AARG72
AGLU90
ALYS123
ALYS274
AHOH633
AHOH681

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 602
ChainResidue
BLYS274
BHOH700
BARG72
BGLU90
BLYS123

site_idAC3
Number of Residues20
DetailsBINDING SITE FOR RESIDUE A3P A 602
ChainResidue
ALYS68
AGLY69
AGLY70
ATHR71
AARG72
AALA73
AARG151
ASER159
AILE225
APHE258
ATYR259
ALEU270
ALYS274
AGLY275
AARG276
AHOH608
AHOH654
AHOH674
AHOH676
AHOH683

site_idAC4
Number of Residues19
DetailsBINDING SITE FOR RESIDUE A3P A 603
ChainResidue
AHOH636
AHOH637
AHOH638
BLYS68
BGLY69
BGLY70
BTHR71
BARG72
BALA73
BARG151
BSER159
BILE225
BPHE258
BTYR259
BLEU270
BLYS274
BGLY275
BARG276
BHIS278

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE A3P A 604
ChainResidue
CLYS68
CGLY69
CGLY70
CTHR71
CARG72
CALA73
CARG151
CSER159
CILE225
CPHE258
CTYR259

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues15
DetailsBINDING: BINDING => ECO:0000269|PubMed:15060080
ChainResidueDetails
ALYS68
BLYS274
CLYS68
CARG151
CSER159
CTYR259
CLYS274
AARG151
ASER159
ATYR259
ALYS274
BLYS68
BARG151
BSER159
BTYR259

site_idSWS_FT_FI2
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN52
CASN196
CASN246
CASN253
AASN196
AASN246
AASN253
BASN52
BASN196
BASN246
BASN253
CASN52

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PDB entries from 2024-07-17

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