Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1VG9

The crystal structures of the REP-1 protein in complex with C-terminally truncated Rab7 protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001568	biological_process	blood vessel development
A	0005092	molecular_function	GDP-dissociation inhibitor activity
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
A	0006612	biological_process	protein targeting to membrane
A	0006886	biological_process	intracellular protein transport
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0016192	biological_process	vesicle-mediated transport
A	0018344	biological_process	protein geranylgeranylation
A	0031267	molecular_function	small GTPase binding
A	0044877	molecular_function	protein-containing complex binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
C	0001568	biological_process	blood vessel development
C	0005092	molecular_function	GDP-dissociation inhibitor activity
C	0005096	molecular_function	GTPase activator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
C	0006612	biological_process	protein targeting to membrane
C	0006886	biological_process	intracellular protein transport
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0016192	biological_process	vesicle-mediated transport
C	0018344	biological_process	protein geranylgeranylation
C	0031267	molecular_function	small GTPase binding
C	0044877	molecular_function	protein-containing complex binding
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
E	0001568	biological_process	blood vessel development
E	0005092	molecular_function	GDP-dissociation inhibitor activity
E	0005096	molecular_function	GTPase activator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
E	0006612	biological_process	protein targeting to membrane
E	0006886	biological_process	intracellular protein transport
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0016192	biological_process	vesicle-mediated transport
E	0018344	biological_process	protein geranylgeranylation
E	0031267	molecular_function	small GTPase binding
E	0044877	molecular_function	protein-containing complex binding
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
G	0001568	biological_process	blood vessel development
G	0005092	molecular_function	GDP-dissociation inhibitor activity
G	0005096	molecular_function	GTPase activator activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
G	0006612	biological_process	protein targeting to membrane
G	0006886	biological_process	intracellular protein transport
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0016192	biological_process	vesicle-mediated transport
G	0018344	biological_process	protein geranylgeranylation
G	0031267	molecular_function	small GTPase binding
G	0044877	molecular_function	protein-containing complex binding
H	0003924	molecular_function	GTPase activity
H	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 2301

Chain	Residue
D	THR22
D	ASP63
D	GDP2300
D	HOH8088
D	HOH8187
D	HOH8422
D	HOH8423

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 2307

Chain	Residue
B	HOH8006
B	HOH8152
B	HOH8358
B	HOH8359
B	THR22
B	GDP2302

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K B 3303

Chain	Residue
B	GLN71
B	P333302
B	HOH8210

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K D 3305

Chain	Residue
D	GLN71
D	P333304

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG H 2304

Chain	Residue
H	THR22
H	ASP63
H	GDP2303
H	HOH9088
H	HOH9187
H	HOH9422
H	HOH9423

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 2306

Chain	Residue
F	THR22
F	GDP2305
F	HOH9006
F	HOH9152
F	HOH9358
F	HOH9359

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K F 3307

Chain	Residue
F	GLN71
F	P333306
F	HOH9210

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K H 3309

Chain	Residue
H	GLN71
H	P333308

site_id	AC9
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GDP D 2300

Chain	Residue
D	ASP16
D	GLY18
D	VAL19
D	GLY20
D	LYS21
D	THR22
D	SER23
D	PHE33
D	ASN125
D	LYS126
D	ASP128
D	LEU129
D	SER155
D	ALA156
D	LYS157
D	MG2301
D	HOH8088
D	HOH8184
D	HOH8187
D	HOH8422
D	HOH8424
D	HOH8425
D	HOH8561

site_id	BC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP B 2302

Chain	Residue
B	GLY18
B	VAL19
B	GLY20
B	LYS21
B	THR22
B	SER23
B	PHE33
B	SER34
B	ASN35
B	ASN125
B	LYS126
B	ASP128
B	LEU129
B	SER155
B	ALA156
B	LYS157
B	MG2307
B	HOH8006
B	HOH8152
B	HOH8196
B	HOH8359
B	HOH8493
B	HOH8494
B	HOH8495

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P33 B 3302

Chain	Residue
A	ARG398
B	GLN71
B	SER101
B	TRP102
B	K3303
B	HOH8362

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P33 D 3304

Chain	Residue
C	ARG398
D	GLN71
D	THR98
D	SER101
D	TRP102
D	GLU105
D	K3305

site_id	BC4
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP H 2303

Chain	Residue
H	LYS21
H	THR22
H	SER23
H	PHE33
H	ASN125
H	LYS126
H	ASP128
H	LEU129
H	SER155
H	ALA156
H	LYS157
H	MG2304
H	HOH9088
H	HOH9184
H	HOH9187
H	HOH9422
H	HOH9424
H	HOH9425
H	HOH9577
H	HOH9594
H	HOH9595
H	GLY18
H	VAL19
H	GLY20

site_id	BC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GDP F 2305

Chain	Residue
F	ASP16
F	GLY18
F	VAL19
F	GLY20
F	LYS21
F	THR22
F	SER23
F	PHE33
F	SER34
F	ASN35
F	ASN125
F	LYS126
F	ASP128
F	LEU129
F	SER155
F	ALA156
F	LYS157
F	MG2306
F	HOH9006
F	HOH9152
F	HOH9163
F	HOH9196
F	HOH9359
F	HOH9493
F	HOH9494
F	HOH9495
F	HOH9497

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P33 F 3306

Chain	Residue
E	ARG398
F	GLN71
F	THR98
F	SER101
F	TRP102
F	GLU105
F	K3307
F	HOH9362

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P33 H 3308

Chain	Residue
G	ARG398
H	GLN71
H	THR98
H	SER101
H	TRP102
H	GLU105
H	K3309
H	HOH9573

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VIIlGDSGVGKtsL

Chain	Residue	Details
B	VAL11-LEU24

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Motif: {"description":"Switch 2","evidences":[{"source":"UniProtKB","id":"P51149","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P51149","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN67

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	GLN67

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	GLN67

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
H	GLN67

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLY18

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	GLY18

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	GLY18

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
H	GLY18

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)