Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0042144 | biological_process | vacuole fusion, non-autophagic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | PRO5 |
| A | TYR6 |
| A | HOH3138 |
| A | HOH3158 |
| A | HOH3208 |
| A | HOH3257 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
| Chain | Residue |
| B | HOH2046 |
| B | HOH2065 |
| B | HOH2067 |
| B | HOH2076 |
| B | HOH2092 |
| A | ASN109 |
| B | ASN34 |
| B | GLU35 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 3001 |
| Chain | Residue |
| A | GLN2 |
| A | ASP41 |
| A | LEU75 |
| A | ASN77 |
| A | ILE79 |
| A | VAL81 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 2001 |
| Chain | Residue |
| A | ASN62 |
| A | SER63 |
| A | HIS64 |
| A | TYR217 |
| A | GLN245 |
| A | SER249 |
| A | GLN275 |
| A | HOH3173 |
| A | HOH3254 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 2002 |
| Chain | Residue |
| A | GOL2018 |
| B | LYS17 |
| B | THR21 |
| B | GLU24 |
| B | LYS55 |
| B | LEU63 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2003 |
| Chain | Residue |
| A | GOL2010 |
| B | GLU24 |
| B | GLU28 |
| B | GLN51 |
| B | SER52 |
| B | LYS55 |
| B | HOH2051 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 2004 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 2005 |
| Chain | Residue |
| A | ASP181 |
| A | ALA187 |
| A | SER188 |
| A | VAL203 |
| A | HOH3290 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 2006 |
| Chain | Residue |
| A | PRO129 |
| A | SER130 |
| A | HOH3027 |
| B | HIS71 |
| B | VAL72 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 2007 |
| Chain | Residue |
| A | TYR6 |
| A | ASP181 |
| A | SER182 |
| A | HOH3282 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 2008 |
| Chain | Residue |
| A | ASN118 |
| A | MET119 |
| A | GLY146 |
| A | HOH3190 |
| A | HOH3271 |
| A | HOH3272 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 2009 |
| Chain | Residue |
| A | ALA48 |
| A | TRP113 |
| A | HOH3023 |
| A | HOH3137 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 2010 |
| Chain | Residue |
| A | SER38 |
| A | PRO40 |
| A | GOL2003 |
| A | GOL2018 |
| A | HOH3167 |
| B | GLU24 |
| B | GLU28 |
| B | LYS55 |
| B | HOH2078 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 2011 |
| Chain | Residue |
| A | ALA1 |
| A | GLY80 |
| A | TYR214 |
| A | HOH3191 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2012 |
| Chain | Residue |
| A | LYS141 |
| A | ALA144 |
| A | HOH3141 |
| A | HOH3224 |
| A | HOH3237 |
| A | HOH3292 |
| A | HOH3293 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 2013 |
| Chain | Residue |
| A | PRO172 |
| A | SER173 |
| A | HOH3088 |
| A | HOH3276 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 2014 |
| Chain | Residue |
| B | SER14 |
| B | LYS17 |
| B | HOH2100 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 2016 |
| Chain | Residue |
| A | ASN243 |
| A | HOH3018 |
| A | HOH3219 |
| A | HOH3294 |
| A | VAL143 |
| A | ALA144 |
| A | SER145 |
| A | GLY146 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 2018 |
| Chain | Residue |
| A | SER38 |
| A | PRO40 |
| A | GOL2010 |
| A | HOH3010 |
| A | HOH3242 |
| A | HOH3281 |
| A | HOH3318 |
| B | GOL2002 |
Functional Information from PROSITE/UniProt
| site_id | PS00136 |
| Number of Residues | 12 |
| Details | SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVIDSGIdssH |
| Chain | Residue | Details |
| A | VAL28-HIS39 | |
| site_id | PS00137 |
| Number of Residues | 11 |
| Details | SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtVAA |
| Chain | Residue | Details |
| A | HIS64-ALA74 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"5249818","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"7840656","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 723 |
| Chain | Residue | Details |
| A | ASP32 | electrostatic interaction, electrostatic stabiliser |
| A | HIS64 | proton acceptor, proton donor |
| A | ASN155 | electrostatic interaction, electrostatic stabiliser |
| A | CSD221 | nucleofuge, nucleophile, proton acceptor, proton donor |
