1UXP

Structural basis for allosteric regulation and substrate specificity of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) from Thermoproteus tenax

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0008886	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
A	0008911	molecular_function	lactaldehyde dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0120533	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (non-phosphorylating) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A1504

Chain	Residue
A	GLU249
A	GLY255
A	HOH2159
A	HOH2166
A	HOH2175
A	HOH2177

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AMP A1502

Chain	Residue
A	GLY134
A	GLY135
A	TYR137
A	PRO139
A	ASP141
A	TRP142
A	ARG154
A	ARG155
A	ARG440
A	TRP498
A	HOH2117
A	HOH2118
A	HOH2327
A	ARG72
A	ARG79
A	ILE133

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site_id	AC3
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAP A1503

Chain	Residue
A	ILE164
A	THR165
A	PRO166
A	PHE167
A	ASN168
A	LYS191
A	SER193
A	ILE194
A	PRO223
A	GLY224
A	ALA227
A	GLU228
A	PHE241
A	THR242
A	GLY243
A	SER244
A	VAL247
A	GLU263
A	LEU264
A	GLY265
A	GLY266
A	CYS297
A	GLU395
A	PHE397
A	LEU423
A	HOH2328
A	HOH2329
A	HOH2330
A	HOH2331

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"15288789","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15288789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UXR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15288789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UXU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11842090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15288789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15288789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11842090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15288789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UXV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS297
A	GLU263
A	ASN168

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