1UPU

STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V, BOUND TO PRODUCT URIDINE-1-MONOPHOSPHATE (UMP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004845	molecular_function	uracil phosphoribosyltransferase activity
A	0005525	molecular_function	GTP binding
A	0016757	molecular_function	glycosyltransferase activity
A	0044206	biological_process	UMP salvage
B	0004845	molecular_function	uracil phosphoribosyltransferase activity
B	0005525	molecular_function	GTP binding
B	0016757	molecular_function	glycosyltransferase activity
B	0044206	biological_process	UMP salvage
C	0004845	molecular_function	uracil phosphoribosyltransferase activity
C	0005525	molecular_function	GTP binding
C	0016757	molecular_function	glycosyltransferase activity
C	0044206	biological_process	UMP salvage
D	0004845	molecular_function	uracil phosphoribosyltransferase activity
D	0005525	molecular_function	GTP binding
D	0016757	molecular_function	glycosyltransferase activity
D	0044206	biological_process	UMP salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 D 899

Chain	Residue
B	LYS59
D	LYS104
D	ARG129
D	ARG158
D	HOH1012

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C 899

Chain	Residue
C	HOH1087
A	LYS59
C	LYS104
C	ARG129
C	ARG158

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 899

Chain	Residue
B	LYS104
B	ARG129
B	ARG158
B	HOH1000
B	HOH1033
D	LYS59

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 899

Chain	Residue
A	LYS104
A	ARG129
A	ARG158
A	HOH1002
A	HOH1036
A	HOH1041
C	LYS59

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE U5P D 999

Chain	Residue
D	ARG137
D	ASP164
D	MET166
D	ALA168
D	THR169
D	ALA170
D	GLY171
D	SER172
D	TYR228
D	ILE229
D	GLY234
D	ASP235
D	PHE236
D	HOH1008
D	HOH1035
D	HOH1056

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE U5P C 999

Chain	Residue
C	ARG137
C	ASP164
C	MET166
C	ALA168
C	THR169
C	ALA170
C	GLY171
C	SER172
C	TYR228
C	ILE229
C	GLY234
C	ASP235
C	PHE236
C	HOH1005
C	HOH1006
C	HOH1036
C	HOH1106

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U5P B 999

Chain	Residue
B	ALA113
B	ARG137
B	ASP164
B	MET166
B	ALA168
B	THR169
B	ALA170
B	GLY171
B	SER172
B	TYR228
B	ILE229
B	GLY234
B	ASP235
B	PHE236
B	HOH1002
B	HOH1007
B	HOH1082
C	HOH1119

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE U5P A 999

Chain	Residue
A	ASP164
A	MET166
A	ALA168
A	THR169
A	ALA170
A	GLY171
A	SER172
A	TYR228
A	ILE229
A	GLY234
A	ASP235
A	PHE236
A	HOH1019
A	HOH1026

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:9628859, ECO:0007744|PDB:1BD3, ECO:0007744|PDB:1UPU

Chain	Residue	Details
D	LYS59
C	LYS59
B	LYS59
A	LYS59

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:11773618, ECO:0007744|PDB:1JLR

Chain	Residue	Details
D	ARG68
D	TYR102
C	ARG68
C	TYR102
B	ARG68
B	TYR102
A	ARG68
A	TYR102

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:11773618, ECO:0007744|PDB:1JLS

Chain	Residue	Details
D	ARG112
C	ARG112
B	ARG112
A	ARG112

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11773618, ECO:0000269|PubMed:9628859, ECO:0007744|PDB:1BD3, ECO:0007744|PDB:1BD4, ECO:0007744|PDB:1JLR, ECO:0007744|PDB:1JLS, ECO:0007744|PDB:1UPU

Chain	Residue	Details
D	ARG129
A	ARG129
A	ARG137
A	ARG158
D	ARG137
D	ARG158
C	ARG129
C	ARG137
C	ARG158
B	ARG129
B	ARG137
B	ARG158

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:11773618, ECO:0000269|PubMed:9628859, ECO:0007744|PDB:1JLS, ECO:0007744|PDB:1UPU

Chain	Residue	Details
D	ASP164
C	ASP164
B	ASP164
A	ASP164

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:9628859, ECO:0007744|PDB:1UPU

Chain	Residue	Details
D	ILE229
D	GLY234
C	ILE229
C	GLY234
B	ILE229
B	GLY234
A	ILE229
A	GLY234

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:11773618, ECO:0007744|PDB:1JLR, ECO:0007744|PDB:1JLS

Chain	Residue	Details
D	ASP235
C	ASP235
B	ASP235
A	ASP235

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
D	THR141
D	ARG137
D	ASP235

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
C	THR141
C	ARG137
C	ASP235

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
B	THR141
B	ARG137
B	ASP235

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
A	THR141
A	ARG137
A	ASP235

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 420

Chain	Residue	Details
D	ARG137	electrostatic stabiliser
D	THR141	electrostatic stabiliser
D	ASP235	electrostatic stabiliser
D	ASP238	modifies pKa

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 420

Chain	Residue	Details
C	ARG137	electrostatic stabiliser
C	THR141	electrostatic stabiliser
C	ASP235	electrostatic stabiliser
C	ASP238	modifies pKa

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 420

Chain	Residue	Details
B	ARG137	electrostatic stabiliser
B	THR141	electrostatic stabiliser
B	ASP235	electrostatic stabiliser
B	ASP238	modifies pKa

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 420

Chain	Residue	Details
A	ARG137	electrostatic stabiliser
A	THR141	electrostatic stabiliser
A	ASP235	electrostatic stabiliser
A	ASP238	modifies pKa

---