1TYS
WATER-MEDIATED SUBSTRATE(SLASH)PRODUCT DISCRIMINATION: THE PRODUCT COMPLEX OF THYMIDYLATE SYNTHASE AT 1.83 ANGSTROMS
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0006417 | biological_process | regulation of translation |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0009314 | biological_process | response to radiation |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
A | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE TMP A 565 |
Chain | Residue |
A | ARG21 |
A | SER167 |
A | CYS168 |
A | ASP169 |
A | ASN177 |
A | HIS207 |
A | TYR209 |
A | DHF566 |
A | HOH579 |
A | HOH802 |
A | TRP80 |
A | TYR94 |
A | ARG126 |
A | ARG127 |
A | SER146 |
A | HIS147 |
A | GLN165 |
A | ARG166 |
site_id | AC2 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE DHF A 566 |
Chain | Residue |
A | HIS51 |
A | ILE79 |
A | TRP80 |
A | TRP83 |
A | LEU143 |
A | ASP169 |
A | GLY173 |
A | PHE176 |
A | TYR209 |
A | VAL262 |
A | ALA263 |
A | TMP565 |
A | HOH580 |
A | HOH613 |
A | HOH807 |
A | HOH808 |
A | HOH822 |
A | HOH825 |
A | HOH829 |
A | HOH830 |
A | HOH846 |
A | HOH867 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0000269|PubMed:9416600 |
Chain | Residue | Details |
A | SER146 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
A | ARG21 | |
A | ARG166 | |
A | ASN177 | |
A | HIS207 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS |
Chain | Residue | Details |
A | HIS51 | |
A | ASP169 | |
A | ALA263 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
A | ARG126 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 5 |
Details | a catalytic site defined by CSA, PubMed 12525151, 12693951 |
Chain | Residue | Details |
A | GLU58 | |
A | ARG166 | |
A | ASP169 | |
A | SER146 | |
A | TYR94 |