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1TNO

Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a KKKSKTKCVIM Peptide Derived from K-Ras4B

Functional Information from GO Data
ChainGOidnamespacecontents
A0004659molecular_functionprenyltransferase activity
A0004660molecular_functionprotein farnesyltransferase activity
A0004661molecular_functionprotein geranylgeranyltransferase activity
A0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
A0004663molecular_functionRab geranylgeranyltransferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005875cellular_componentmicrotubule associated complex
A0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
A0005965cellular_componentprotein farnesyltransferase complex
A0007167biological_processenzyme-linked receptor protein signaling pathway
A0008017molecular_functionmicrotubule binding
A0008270molecular_functionzinc ion binding
A0008284biological_processpositive regulation of cell population proliferation
A0008318molecular_functionprotein prenyltransferase activity
A0014070biological_processresponse to organic cyclic compound
A0018342biological_processprotein prenylation
A0018343biological_processprotein farnesylation
A0018344biological_processprotein geranylgeranylation
A0030971molecular_functionreceptor tyrosine kinase binding
A0034097biological_processresponse to cytokine
A0035022biological_processpositive regulation of Rac protein signal transduction
A0036094molecular_functionsmall molecule binding
A0042277molecular_functionpeptide binding
A0043014molecular_functionalpha-tubulin binding
A0043066biological_processnegative regulation of apoptotic process
A0045787biological_processpositive regulation of cell cycle
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
A0060090molecular_functionmolecular adaptor activity
A0090044biological_processpositive regulation of tubulin deacetylation
A1901363molecular_functionheterocyclic compound binding
A1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
B0003824molecular_functioncatalytic activity
B0004659molecular_functionprenyltransferase activity
B0004661molecular_functionprotein geranylgeranyltransferase activity
B0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
B0005515molecular_functionprotein binding
B0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
B0008270molecular_functionzinc ion binding
B0008284biological_processpositive regulation of cell population proliferation
B0008318molecular_functionprotein prenyltransferase activity
B0018344biological_processprotein geranylgeranylation
B0034097biological_processresponse to cytokine
B0036094molecular_functionsmall molecule binding
B0042277molecular_functionpeptide binding
B0045787biological_processpositive regulation of cell cycle
B0046872molecular_functionmetal ion binding
B0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
B1901363molecular_functionheterocyclic compound binding
C0004659molecular_functionprenyltransferase activity
C0004660molecular_functionprotein farnesyltransferase activity
C0004661molecular_functionprotein geranylgeranyltransferase activity
C0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
C0004663molecular_functionRab geranylgeranyltransferase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005875cellular_componentmicrotubule associated complex
C0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
C0005965cellular_componentprotein farnesyltransferase complex
C0007167biological_processenzyme-linked receptor protein signaling pathway
C0008017molecular_functionmicrotubule binding
C0008270molecular_functionzinc ion binding
C0008284biological_processpositive regulation of cell population proliferation
C0008318molecular_functionprotein prenyltransferase activity
C0014070biological_processresponse to organic cyclic compound
C0018342biological_processprotein prenylation
C0018343biological_processprotein farnesylation
C0018344biological_processprotein geranylgeranylation
C0030971molecular_functionreceptor tyrosine kinase binding
C0034097biological_processresponse to cytokine
C0035022biological_processpositive regulation of Rac protein signal transduction
C0036094molecular_functionsmall molecule binding
C0042277molecular_functionpeptide binding
C0043014molecular_functionalpha-tubulin binding
C0043066biological_processnegative regulation of apoptotic process
C0045787biological_processpositive regulation of cell cycle
C0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
C0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
C0060090molecular_functionmolecular adaptor activity
C0090044biological_processpositive regulation of tubulin deacetylation
C1901363molecular_functionheterocyclic compound binding
C1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
D0003824molecular_functioncatalytic activity
D0004659molecular_functionprenyltransferase activity
D0004661molecular_functionprotein geranylgeranyltransferase activity
D0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
D0005515molecular_functionprotein binding
D0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
D0008270molecular_functionzinc ion binding
D0008284biological_processpositive regulation of cell population proliferation
D0008318molecular_functionprotein prenyltransferase activity
D0018344biological_processprotein geranylgeranylation
D0034097biological_processresponse to cytokine
D0036094molecular_functionsmall molecule binding
D0042277molecular_functionpeptide binding
D0045787biological_processpositive regulation of cell cycle
D0046872molecular_functionmetal ion binding
D0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
D1901363molecular_functionheterocyclic compound binding
E0004659molecular_functionprenyltransferase activity
E0004660molecular_functionprotein farnesyltransferase activity
E0004661molecular_functionprotein geranylgeranyltransferase activity
E0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
E0004663molecular_functionRab geranylgeranyltransferase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005875cellular_componentmicrotubule associated complex
E0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
E0005965cellular_componentprotein farnesyltransferase complex
E0007167biological_processenzyme-linked receptor protein signaling pathway
E0008017molecular_functionmicrotubule binding
E0008270molecular_functionzinc ion binding
E0008284biological_processpositive regulation of cell population proliferation
E0008318molecular_functionprotein prenyltransferase activity
E0014070biological_processresponse to organic cyclic compound
E0018342biological_processprotein prenylation
E0018343biological_processprotein farnesylation
E0018344biological_processprotein geranylgeranylation
E0030971molecular_functionreceptor tyrosine kinase binding
E0034097biological_processresponse to cytokine
E0035022biological_processpositive regulation of Rac protein signal transduction
E0036094molecular_functionsmall molecule binding
E0042277molecular_functionpeptide binding
E0043014molecular_functionalpha-tubulin binding
E0043066biological_processnegative regulation of apoptotic process
E0045787biological_processpositive regulation of cell cycle
E0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
E0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
E0060090molecular_functionmolecular adaptor activity
E0090044biological_processpositive regulation of tubulin deacetylation
E1901363molecular_functionheterocyclic compound binding
E1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
F0003824molecular_functioncatalytic activity
F0004659molecular_functionprenyltransferase activity
F0004661molecular_functionprotein geranylgeranyltransferase activity
F0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
F0005515molecular_functionprotein binding
F0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
F0008270molecular_functionzinc ion binding
F0008284biological_processpositive regulation of cell population proliferation
F0008318molecular_functionprotein prenyltransferase activity
F0018344biological_processprotein geranylgeranylation
F0034097biological_processresponse to cytokine
F0036094molecular_functionsmall molecule binding
F0042277molecular_functionpeptide binding
F0045787biological_processpositive regulation of cell cycle
F0046872molecular_functionmetal ion binding
F0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
F1901363molecular_functionheterocyclic compound binding
G0004659molecular_functionprenyltransferase activity
G0004660molecular_functionprotein farnesyltransferase activity
G0004661molecular_functionprotein geranylgeranyltransferase activity
G0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
G0004663molecular_functionRab geranylgeranyltransferase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005875cellular_componentmicrotubule associated complex
G0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
G0005965cellular_componentprotein farnesyltransferase complex
G0007167biological_processenzyme-linked receptor protein signaling pathway
G0008017molecular_functionmicrotubule binding
G0008270molecular_functionzinc ion binding
G0008284biological_processpositive regulation of cell population proliferation
G0008318molecular_functionprotein prenyltransferase activity
G0014070biological_processresponse to organic cyclic compound
G0018342biological_processprotein prenylation
G0018343biological_processprotein farnesylation
G0018344biological_processprotein geranylgeranylation
G0030971molecular_functionreceptor tyrosine kinase binding
G0034097biological_processresponse to cytokine
G0035022biological_processpositive regulation of Rac protein signal transduction
G0036094molecular_functionsmall molecule binding
G0042277molecular_functionpeptide binding
G0043014molecular_functionalpha-tubulin binding
G0043066biological_processnegative regulation of apoptotic process
G0045787biological_processpositive regulation of cell cycle
G0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
G0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
G0060090molecular_functionmolecular adaptor activity
G0090044biological_processpositive regulation of tubulin deacetylation
G1901363molecular_functionheterocyclic compound binding
G1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
H0003824molecular_functioncatalytic activity
H0004659molecular_functionprenyltransferase activity
H0004661molecular_functionprotein geranylgeranyltransferase activity
H0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
H0005515molecular_functionprotein binding
H0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
H0008270molecular_functionzinc ion binding
H0008284biological_processpositive regulation of cell population proliferation
H0008318molecular_functionprotein prenyltransferase activity
H0018344biological_processprotein geranylgeranylation
H0034097biological_processresponse to cytokine
H0036094molecular_functionsmall molecule binding
H0042277molecular_functionpeptide binding
H0045787biological_processpositive regulation of cell cycle
H0046872molecular_functionmetal ion binding
H0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
H1901363molecular_functionheterocyclic compound binding
I0004659molecular_functionprenyltransferase activity
I0004660molecular_functionprotein farnesyltransferase activity
I0004661molecular_functionprotein geranylgeranyltransferase activity
I0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
I0004663molecular_functionRab geranylgeranyltransferase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005875cellular_componentmicrotubule associated complex
I0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
I0005965cellular_componentprotein farnesyltransferase complex
I0007167biological_processenzyme-linked receptor protein signaling pathway
I0008017molecular_functionmicrotubule binding
I0008270molecular_functionzinc ion binding
I0008284biological_processpositive regulation of cell population proliferation
I0008318molecular_functionprotein prenyltransferase activity
I0014070biological_processresponse to organic cyclic compound
I0018342biological_processprotein prenylation
I0018343biological_processprotein farnesylation
I0018344biological_processprotein geranylgeranylation
I0030971molecular_functionreceptor tyrosine kinase binding
I0034097biological_processresponse to cytokine
I0035022biological_processpositive regulation of Rac protein signal transduction
I0036094molecular_functionsmall molecule binding
I0042277molecular_functionpeptide binding
I0043014molecular_functionalpha-tubulin binding
I0043066biological_processnegative regulation of apoptotic process
I0045787biological_processpositive regulation of cell cycle
I0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
I0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
I0060090molecular_functionmolecular adaptor activity
I0090044biological_processpositive regulation of tubulin deacetylation
I1901363molecular_functionheterocyclic compound binding
I1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
J0003824molecular_functioncatalytic activity
J0004659molecular_functionprenyltransferase activity
J0004661molecular_functionprotein geranylgeranyltransferase activity
J0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
J0005515molecular_functionprotein binding
J0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
J0008270molecular_functionzinc ion binding
J0008284biological_processpositive regulation of cell population proliferation
J0008318molecular_functionprotein prenyltransferase activity
J0018344biological_processprotein geranylgeranylation
J0034097biological_processresponse to cytokine
J0036094molecular_functionsmall molecule binding
J0042277molecular_functionpeptide binding
J0045787biological_processpositive regulation of cell cycle
J0046872molecular_functionmetal ion binding
J0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
J1901363molecular_functionheterocyclic compound binding
K0004659molecular_functionprenyltransferase activity
K0004660molecular_functionprotein farnesyltransferase activity
K0004661molecular_functionprotein geranylgeranyltransferase activity
K0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
K0004663molecular_functionRab geranylgeranyltransferase activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005875cellular_componentmicrotubule associated complex
K0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
K0005965cellular_componentprotein farnesyltransferase complex
K0007167biological_processenzyme-linked receptor protein signaling pathway
K0008017molecular_functionmicrotubule binding
K0008270molecular_functionzinc ion binding
K0008284biological_processpositive regulation of cell population proliferation
K0008318molecular_functionprotein prenyltransferase activity
K0014070biological_processresponse to organic cyclic compound
K0018342biological_processprotein prenylation
K0018343biological_processprotein farnesylation
K0018344biological_processprotein geranylgeranylation
K0030971molecular_functionreceptor tyrosine kinase binding
K0034097biological_processresponse to cytokine
K0035022biological_processpositive regulation of Rac protein signal transduction
K0036094molecular_functionsmall molecule binding
K0042277molecular_functionpeptide binding
K0043014molecular_functionalpha-tubulin binding
K0043066biological_processnegative regulation of apoptotic process
K0045787biological_processpositive regulation of cell cycle
K0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
K0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
K0060090molecular_functionmolecular adaptor activity
K0090044biological_processpositive regulation of tubulin deacetylation
K1901363molecular_functionheterocyclic compound binding
K1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
L0003824molecular_functioncatalytic activity
L0004659molecular_functionprenyltransferase activity
L0004661molecular_functionprotein geranylgeranyltransferase activity
L0004662molecular_functionCAAX-protein geranylgeranyltransferase activity
L0005515molecular_functionprotein binding
L0005953cellular_componentCAAX-protein geranylgeranyltransferase complex
L0008270molecular_functionzinc ion binding
L0008284biological_processpositive regulation of cell population proliferation
L0008318molecular_functionprotein prenyltransferase activity
L0018344biological_processprotein geranylgeranylation
L0034097biological_processresponse to cytokine
L0036094molecular_functionsmall molecule binding
L0042277molecular_functionpeptide binding
L0045787biological_processpositive regulation of cell cycle
L0046872molecular_functionmetal ion binding
L0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
L1901363molecular_functionheterocyclic compound binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 378
ChainResidue
BASP269
BCYS271
BHIS321
MCYS8

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 378
ChainResidue
DASP269
DCYS271
DHIS321
NCYS8

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 378
ChainResidue
FCYS271
FHIS321
OCYS8
FASP269

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 378
ChainResidue
HASP269
HCYS271
HHIS321
PCYS8

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN J 378
ChainResidue
JASP269
JCYS271
JHIS321
QCYS8

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN L 378
ChainResidue
LASP269
LCYS271
LHIS321
RCYS8

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL D 379
ChainResidue
DLYS284
DILE285
DPHE286
DGLN287

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL F 379
ChainResidue
FLYS284
FILE285
FPHE286
FGLN287

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL H 379
ChainResidue
HLYS284
HILE285
HPHE286
HGLN287

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL L 379
ChainResidue
LLYS284
LILE285
LPHE286
LGLN287

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MES F 380
ChainResidue
FCYS338
FLYS339
FTHR348
FARG349

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MES B 379
ChainResidue
BCYS338
BLYS339
BTHR348
BARG349

site_idBC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE MGM B 380
ChainResidue
ALYS164
ALYS198
ATYR200
BARG173
BHIS219
BARG263
BLYS266
BTYR272
BTRP275
BHOH396
BHOH398
BHOH412
MILE10

site_idBC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE MGM D 380
ChainResidue
CLYS164
CLYS198
CTYR200
CHOH401
DARG173
DHIS219
DARG263
DLYS266
DTYR272
DTRP275
DHOH414
DHOH428
DHOH429
NILE10

site_idBC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE MGM F 381
ChainResidue
ELYS164
ELYS198
ETYR200
FARG173
FHIS219
FARG263
FLYS266
FTYR272
FTRP275
FHOH408
FHOH423
FHOH427
FHOH431
FHOH433
FHOH437
OVAL9
OILE10

site_idBC7
Number of Residues12
DetailsBINDING SITE FOR RESIDUE MGM H 380
ChainResidue
HTRP275
HHOH392
HHOH404
HHOH408
PILE10
GLYS164
GTYR200
HARG173
HHIS219
HARG263
HLYS266
HTYR272

site_idBC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE MGM J 379
ChainResidue
ILYS164
ITYR200
IHOH406
JARG173
JHIS219
JARG263
JLYS266
JTYR272
JTRP275
JHOH401
JHOH414
JHOH424
JHOH425
QILE10

site_idBC9
Number of Residues16
DetailsBINDING SITE FOR RESIDUE MGM L 380
ChainResidue
KLYS164
KLYS198
KTYR200
KHOH428
LARG173
LHIS219
LARG263
LLYS266
LTYR272
LTRP275
LHOH429
LHOH438
LHOH460
LHOH473
RVAL9
RILE10

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsBINDING: BINDING => ECO:0000269|PubMed:14609943, ECO:0007744|PDB:1N4P
ChainResidueDetails
BHIS219
DCYS271
DTYR272
DHIS321
FHIS219
FARG263
FASP269
FCYS271
FTYR272
FHIS321
HHIS219
BARG263
HARG263
HASP269
HCYS271
HTYR272
HHIS321
JHIS219
JARG263
JASP269
JCYS271
JTYR272
BASP269
JHIS321
LHIS219
LARG263
LASP269
LCYS271
LTYR272
LHIS321
BCYS271
BTYR272
BHIS321
DHIS219
DARG263
DASP269

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d8d
ChainResidueDetails
ALYS164
BTYR272

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d8d
ChainResidueDetails
CLYS164
DTYR272

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d8d
ChainResidueDetails
FTYR272
ELYS164

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d8d
ChainResidueDetails
HTYR272
GLYS164

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d8d
ChainResidueDetails
JTYR272
ILYS164

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d8d
ChainResidueDetails
KLYS164
LTYR272

site_idMCSA1
Number of Residues1
DetailsM-CSA 484
ChainResidueDetails
ALYS164electrostatic stabiliser

site_idMCSA2
Number of Residues1
DetailsM-CSA 484
ChainResidueDetails
CLYS164electrostatic stabiliser

site_idMCSA3
Number of Residues1
DetailsM-CSA 484
ChainResidueDetails
ELYS164electrostatic stabiliser

site_idMCSA4
Number of Residues1
DetailsM-CSA 484
ChainResidueDetails
GLYS164electrostatic stabiliser

site_idMCSA5
Number of Residues1
DetailsM-CSA 484
ChainResidueDetails
ILYS164electrostatic stabiliser

site_idMCSA6
Number of Residues1
DetailsM-CSA 484
ChainResidueDetails
KLYS164electrostatic stabiliser

226707

PDB entries from 2024-10-30

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