1TC1

A 1.4 ANGSTROM CRYSTAL STRUCTURE FOR THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE OF TRYPANOSOMA CRUZI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMB A 900

Chain	Residue
A	ASP115
A	LYS143
A	ALA163
A	PHE164
A	VAL165
A	ASP171

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMB B 901

Chain	Residue
B	PHE164
B	VAL165
B	ASP171
B	ASP115
B	LYS143
B	ALA163

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site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MES A 800

Chain	Residue
A	GLU111
A	ILE113
A	VAL114
A	ASP115
A	THR116
A	ALA117
A	LEU118
A	THR119
A	LEU120

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site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES B 801

Chain	Residue
B	ILE113
B	VAL114
B	ASP115
B	THR116
B	ALA117
B	LEU118
B	THR119
B	LEU120

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Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIVDTAlT

Chain	Residue	Details
A	VAL107-THR119

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