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1S9D

ARF1[DELTA 1-17]-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN

Replaces:  1R8R
Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0002090biological_processregulation of receptor internalization
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006886biological_processintracellular protein transport
A0014069cellular_componentpostsynaptic density
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
A0042583cellular_componentchromaffin granule
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0060292biological_processlong-term synaptic depression
A0097061biological_processdendritic spine organization
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0032012biological_processregulation of ARF protein signal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 402
ChainResidue
ATHR31
AGDP401
AHOH419
AHOH432
AHOH458
AHOH544

site_idAC2
Number of Residues23
DetailsBINDING SITE FOR RESIDUE GDP A 401
ChainResidue
ALYS30
ATHR31
ATHR32
AASN126
ALYS127
AASP129
ALEU130
ACYS159
AALA160
ATHR161
AMG402
AHOH419
AHOH452
AHOH458
AHOH464
AHOH482
AHOH490
AHOH500
AHOH512
AHOH543
AALA27
AALA28
AGLY29

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE AFB A 403
ChainResidue
AVAL53
ATHR64
ATRP66
AASP67
ATRP78
ATYR81
AHOH438
AHOH446
AHOH469
ETYR190
EMET194

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:14654833, ECO:0000269|PubMed:24058294, ECO:0007744|PDB:1R8Q, ECO:0007744|PDB:1R8S, ECO:0007744|PDB:1S9D, ECO:0007744|PDB:4C0A
ChainResidueDetails
ALEU25
ALYS127
ATHR161

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN71

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA27

222036

PDB entries from 2024-07-03

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