1RY7

Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001658	biological_process	branching involved in ureteric bud morphogenesis
A	0005104	molecular_function	fibroblast growth factor receptor binding
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005938	cellular_component	cell cortex
A	0007165	biological_process	signal transduction
A	0008083	molecular_function	growth factor activity
A	0008201	molecular_function	heparin binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008543	biological_process	fibroblast growth factor receptor signaling pathway
A	0009653	biological_process	anatomical structure morphogenesis
A	0010595	biological_process	positive regulation of endothelial cell migration
A	0022008	biological_process	neurogenesis
A	0030154	biological_process	cell differentiation
A	0030334	biological_process	regulation of cell migration
A	0030335	biological_process	positive regulation of cell migration
A	0031012	cellular_component	extracellular matrix
A	0032148	biological_process	activation of protein kinase B activity
A	0034605	biological_process	cellular response to heat
A	0042060	biological_process	wound healing
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0043410	biological_process	positive regulation of MAPK cascade
A	0044548	molecular_function	S100 protein binding
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0045766	biological_process	positive regulation of angiogenesis
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051781	biological_process	positive regulation of cell division
A	0060681	biological_process	branch elongation involved in ureteric bud branching
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0072163	biological_process	mesonephric epithelium development
A	1901509	biological_process	regulation of endothelial tube morphogenesis
A	1902533	biological_process	positive regulation of intracellular signal transduction
A	1903672	biological_process	positive regulation of sprouting angiogenesis
A	1905330	biological_process	regulation of morphogenesis of an epithelium
A	2000544	biological_process	regulation of endothelial cell chemotaxis to fibroblast growth factor

Functional Information from PROSITE/UniProt

site_id	PS00247
Number of Residues	24
Details	HBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY

Chain	Residue	Details
A	GLY86-TYR109

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Heparin-binding"}

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Residue

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Motif: {"description":"Nuclear localization signal"}

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Residue

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11069186","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9655399","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	93
Details	Domain: {"description":"Ig-like C2-type 2"}

Chain

Residue

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site_id	SWS_FT_FI5
Number of Residues	102
Details	Domain: {"description":"Ig-like C2-type 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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