1RE0
Structure of ARF1-GDP bound to Sec7 domain complexed with Brefeldin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0002090 | biological_process | regulation of receptor internalization |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006878 | biological_process | intracellular copper ion homeostasis |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030017 | cellular_component | sarcomere |
| A | 0031252 | cellular_component | cell leading edge |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034315 | biological_process | regulation of Arp2/3 complex-mediated actin nucleation |
| A | 0043005 | cellular_component | neuron projection |
| A | 0045202 | cellular_component | synapse |
| A | 0060292 | biological_process | long-term synaptic depression |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097061 | biological_process | dendritic spine organization |
| A | 0098586 | biological_process | cellular response to virus |
| A | 1990386 | biological_process | mitotic cleavage furrow ingression |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0032012 | biological_process | regulation of ARF protein signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 701 |
| Chain | Residue |
| A | THR31 |
| A | GDP700 |
| A | HOH704 |
| A | HOH705 |
| A | HOH742 |
| A | HOH743 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GDP A 700 |
| Chain | Residue |
| A | LYS30 |
| A | THR31 |
| A | THR32 |
| A | ASN126 |
| A | LYS127 |
| A | ASP129 |
| A | LEU130 |
| A | CYS159 |
| A | ALA160 |
| A | MG701 |
| A | HOH704 |
| A | HOH705 |
| A | HOH732 |
| A | ALA27 |
| A | ALA28 |
| A | GLY29 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AFB A 702 |
| Chain | Residue |
| A | VAL53 |
| A | THR64 |
| A | VAL65 |
| A | TRP66 |
| A | ASP67 |
| A | ILE74 |
| A | TRP78 |
| A | TYR81 |
| A | HOH713 |
| A | HOH716 |
| A | HOH718 |
| B | TYR256 |
| B | MET260 |
| B | THR263 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CIT A 703 |
| Chain | Residue |
| A | SER147 |
| A | LEU148 |
| A | ARG149 |
| A | HIS150 |
| A | ARG151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:7990966, ECO:0007744|PDB:1HUR |
| Chain | Residue | Details |
| A | LEU25 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14690595, ECO:0000269|PubMed:15308674, ECO:0000269|PubMed:7990966, ECO:0000269|Ref.34, ECO:0007744|PDB:1HUR, ECO:0007744|PDB:1RE0, ECO:0007744|PDB:1U81, ECO:0007744|PDB:3O47 |
| Chain | Residue | Details |
| A | LYS127 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15308674, ECO:0000269|PubMed:7990966, ECO:0000269|Ref.34, ECO:0007744|PDB:1HUR, ECO:0007744|PDB:1RE0, ECO:0007744|PDB:3O47 |
| Chain | Residue | Details |
| A | THR161 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN71 |
