1RBQ

Human GAR Tfase complex structure with 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009058	biological_process	biosynthetic process
B	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0009058	biological_process	biosynthetic process
C	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
C	0006189	biological_process	'de novo' IMP biosynthetic process
C	0009058	biological_process	biosynthetic process
D	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
D	0006189	biological_process	'de novo' IMP biosynthetic process
D	0009058	biological_process	biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 521

Chain	Residue
A	THR10
A	GLY11
A	SER12
A	ASN13
A	LYS170
A	HOH523
A	HOH527
A	HOH555

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 522

Chain	Residue
A	ARG168
A	HOH608
A	HOH610
A	LYS157

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B 621

Chain	Residue
B	THR10
B	GLY11
B	SER12
B	ASN13
B	LYS170
B	HOH624
B	HOH632
B	HOH654

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 622

Chain	Residue
B	LYS157
B	ARG168
B	HOH633
B	HOH711

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 C 721

Chain	Residue
C	GLY11
C	SER12
C	ASN13
C	LEU14
C	GLN15
C	ALA16
C	LYS45
C	HIS174
C	HOH749
C	HOH787

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 D 821

Chain	Residue
D	GLY11
D	SER12
D	ASN13
D	LEU14
D	GLN15
D	ALA16
D	LYS45
D	HIS174
D	HOH850
D	HOH857

---

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE KEU A 510

Chain	Residue
A	ARG64
A	LEU85
A	MET89
A	ARG90
A	ILE91
A	LEU92
A	ASN106
A	HIS108
A	PRO109
A	GLY117
A	SER118
A	VAL139
A	ALA140
A	GLU141
A	ASP142
A	VAL143
A	ASP144
A	HOH530
A	HOH532
A	HOH537
A	HOH543
A	HOH562
A	HOH564
A	HOH574
A	HOH623

---

site_id	AC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE KEU B 610

Chain	Residue
B	ARG64
B	LEU85
B	MET89
B	ARG90
B	ILE91
B	LEU92
B	ASN106
B	HIS108
B	PRO109
B	GLY117
B	SER118
B	VAL139
B	ALA140
B	GLU141
B	VAL143
B	ASP144
B	HOH623
B	HOH637
B	HOH646
B	HOH660
B	HOH706
C	HOH750

---

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE KEU C 710

Chain	Residue
C	PRO109
C	GLY117
C	SER118
C	VAL139
C	ALA140
C	GLU141
C	VAL143
C	ASP144
C	HOH724
C	ARG64
C	LEU85
C	MET89
C	ARG90
C	ILE91
C	LEU92
C	ASN106
C	HIS108

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE KEU D 810

Chain	Residue
D	ARG64
D	LEU85
D	MET89
D	ARG90
D	ILE91
D	LEU92
D	VAL97
D	ASN106
D	HIS108
D	PRO109
D	GLY117
D	SER118
D	VAL139
D	ALA140
D	GLU141
D	VAL143
D	ASP144
D	HOH829

---

Functional Information from PROSITE/UniProt

site_id	PS00373
Number of Residues	24
Details	GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV

Chain	Residue	Details
A	GLY133-VAL156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	HIS108
B	HIS108
C	HIS108
D	HIS108

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:12450384, ECO:0000269|PubMed:16026156, ECO:0007744|PDB:1MEN, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	GLY11
A	LYS170
B	GLY11
B	LYS170
C	GLY11
C	LYS170
D	GLY11
D	LYS170

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0007744|PDB:1NJS

Chain	Residue	Details
A	ARG64
A	ASN106
B	ARG64
B	ASN106
C	ARG64
C	ASN106
D	ARG64
D	ASN106

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:16026156, ECO:0007744|PDB:1NJS, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	MET89
A	ALA140
B	MET89
B	ALA140
C	MET89
C	ALA140
D	MET89
D	ALA140

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	SITE: Raises pKa of active site His => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	ASP144
B	ASP144
C	ASP144
D	ASP144

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
A	THR135
A	ASN106
A	ASP144
A	HIS108

---

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
B	ASP144
B	HIS108

---

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
C	ASP144
C	HIS108

---

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
D	ASP144
D	HIS108

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
B	THR135
B	ASN106
B	ASP144
B	HIS108

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
C	THR135
C	ASN106
C	ASP144
C	HIS108

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
D	THR135
D	ASN106
D	ASP144
D	HIS108

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
A	ASN106
A	ASP144
A	HIS108

---

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
B	ASN106
B	ASP144
B	HIS108

---

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
C	ASN106
C	ASP144
C	HIS108

---

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
D	ASN106
D	ASP144
D	HIS108

---

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1c2t

Chain	Residue	Details
A	ASP144
A	HIS108

---