1R8S
ARF1[DELTA1-17]-GDP IN COMPLEX WITH A SEC7 DOMAIN CARRYING THE MUTATION OF THE CATALYTIC GLUTAMATE TO LYSINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002090 | biological_process | regulation of receptor internalization |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0015031 | biological_process | protein transport |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0034315 | biological_process | regulation of Arp2/3 complex-mediated actin nucleation |
| A | 0042583 | cellular_component | chromaffin granule |
| A | 0043005 | cellular_component | neuron projection |
| A | 0045202 | cellular_component | synapse |
| A | 0060292 | biological_process | long-term synaptic depression |
| A | 0097061 | biological_process | dendritic spine organization |
| E | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| E | 0032012 | biological_process | regulation of ARF protein signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 E 501 |
| Chain | Residue |
| A | HOH538 |
| E | GLY116 |
| E | ARG118 |
| E | LYS156 |
| E | GLN158 |
| E | LYS159 |
| E | ARG162 |
| E | HOH564 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO3 E 502 |
| Chain | Residue |
| E | PRO154 |
| E | GLY155 |
| E | LYS156 |
| A | ASN52 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GDP A 401 |
| Chain | Residue |
| A | ALA27 |
| A | ALA28 |
| A | GLY29 |
| A | LYS30 |
| A | THR31 |
| A | THR32 |
| A | ASN126 |
| A | LYS127 |
| A | ASP129 |
| A | LEU130 |
| A | CYS159 |
| A | ALA160 |
| A | HOH521 |
| A | HOH532 |
| A | HOH538 |
| A | HOH542 |
| A | HOH546 |
| A | HOH550 |
| A | HOH566 |
| A | HOH648 |
| E | LYS156 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME A 506 |
| Chain | Residue |
| A | ARG19 |
| A | HOH610 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT A 503 |
| Chain | Residue |
| A | ARG149 |
| A | HIS150 |
| A | ARG151 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT A 504 |
| Chain | Residue |
| A | ARG79 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT E 505 |
| Chain | Residue |
| E | ASN139 |
| E | SER237 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14654833","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24058294","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 129 |
| Details | Domain: {"description":"SEC7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00189","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN71 |
