1R8Q

FULL-LENGTH ARF1-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0002090	biological_process	regulation of receptor internalization
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006886	biological_process	intracellular protein transport
A	0014069	cellular_component	postsynaptic density
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
A	0042583	cellular_component	chromaffin granule
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0060292	biological_process	long-term synaptic depression
A	0097061	biological_process	dendritic spine organization
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0002090	biological_process	regulation of receptor internalization
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006886	biological_process	intracellular protein transport
B	0014069	cellular_component	postsynaptic density
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
B	0016787	molecular_function	hydrolase activity
B	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
B	0042583	cellular_component	chromaffin granule
B	0043005	cellular_component	neuron projection
B	0045202	cellular_component	synapse
B	0060292	biological_process	long-term synaptic depression
B	0097061	biological_process	dendritic spine organization
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0032012	biological_process	regulation of ARF protein signal transduction
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0032012	biological_process	regulation of ARF protein signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	THR31
A	G3D401
A	HOH410
A	HOH450
A	HOH504
A	HOH510

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 502

Chain	Residue
B	HOH563
B	HOH567
B	HOH570
B	THR31
B	G3D501
B	HOH517

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 601

Chain	Residue
E	HIS127
E	ASP131
F	HIS127
F	ASP131

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE G3D A 401

Chain	Residue
A	ALA27
A	ALA28
A	GLY29
A	LYS30
A	THR31
A	THR32
A	ASN126
A	LYS127
A	ASP129
A	LEU130
A	CYS159
A	ALA160
A	THR161
A	MG402
A	HOH410
A	HOH432
A	HOH435
A	HOH445
A	HOH504
A	HOH510
B	LYS142

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AFB A 403

Chain	Residue
A	VAL53
A	THR64
A	VAL65
A	TRP66
A	ASP67
A	TRP78
A	TYR81
A	HOH406
A	HOH414
E	TYR190
E	MET194

---

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE G3D B 501

Chain	Residue
A	LYS142
B	ALA27
B	ALA28
B	GLY29
B	LYS30
B	THR31
B	THR32
B	ASN126
B	LYS127
B	ASP129
B	LEU130
B	CYS159
B	ALA160
B	THR161
B	MG502
B	HOH563
B	HOH567
B	HOH569
B	HOH570

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AFB B 503

Chain	Residue
B	VAL53
B	THR64
B	VAL65
B	TRP66
B	ASP67
B	TRP78
B	TYR81
B	HOH506
B	HOH508
B	HOH513
F	TYR190
F	MET194
F	THR197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:14654833, ECO:0000269|PubMed:24058294, ECO:0007744|PDB:1R8Q, ECO:0007744|PDB:1R8S, ECO:0007744|PDB:1S9D, ECO:0007744|PDB:4C0A

Chain	Residue	Details
A	GLY24
A	ASN126
A	ALA160
B	GLY24
B	ASN126
B	ALA160

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylglycine; alternate => ECO:0000250|UniProtKB:P84077

Chain	Residue	Details
A	GLY2
B	GLY2

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	LIPID: N-myristoyl glycine; alternate => ECO:0000250|UniProtKB:P84077

Chain	Residue	Details
A	GLY2
B	GLY2

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