English 日本語简体中文繁體中文 한국어

✖

Menu

RCSB PDB PDBe BMRB Adv. Search Search help

Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1R4U

URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR OXONIC ACID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004846	molecular_function	urate oxidase activity
A	0005777	cellular_component	peroxisome
A	0006144	biological_process	purine nucleobase metabolic process
A	0006145	biological_process	purine nucleobase catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019628	biological_process	urate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OXC A 999

Chain	Residue
A	TYR8
A	ASN254
A	HOH1000
A	ILE54
A	THR57
A	ASP58
A	PHE159
A	ARG176
A	SER226
A	VAL227
A	GLN228

Functional Information from PROSITE/UniProt

site_id	PS00366
Number of Residues	28
Details	URICASE Uricase signature. LtVLKSTnSqFwgFlrdeYttLketwdR

Chain	Residue	Details
A	LEU149-ARG176

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:24466188, ECO:0007744\|PDB:4N3M, ECO:0007744\|PDB:4N9M, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V

Chain	Residue	Details
A	ASP11
A	ASP58
A	TYR257

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2FXL, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	ASP58

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S

Chain	Residue	Details
A	SER59

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	TRP160

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	ILE177

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	GLN228

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	ALA229

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6

Chain	Residue	Details
A	LYS255

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0000305\|PubMed:1339455, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R4U, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1R56, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FXL, ECO:0007744\|PDB:3BJP, ECO:0007744\|PDB:4FSK

Chain	Residue	Details
A	ALA2

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
A	GLN228
A	ARG176

site_id	MCSA1
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
A	ASP11	hydrogen bond donor, proton acceptor, proton donor, proton relay
A	ASP58	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	ILE177	electrostatic stabiliser
A	ALA229	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	TYR257	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

227111

PDB entries from 2024-11-06

PDB statistics

PDBj update info

Contact PDBj

numon