3BJP

Urate oxidase cyanide uric acid ternary complex

Summary for 3BJP

Entry DOI	10.2210/pdb3bjp/pdb
Related	1R4S 1R4U 1R51 1R56 1WRR 1WS2
Descriptor	Uricase, SODIUM ION, CYANIDE ION, ... (6 entities in total)
Functional Keywords	uric acid, cyanide, inhibition, degradation mechanism, acetylation, oxidoreductase, peroxisome, purine metabolism
Biological source	Aspergillus flavus
Cellular location	Peroxisome: Q00511
Total number of polymer chains	1
Total formula weight	34418.72
Authors	Gabison, L.,Prange, T.,Colloc'h, N.,El Hajji, M.,Castro, B.,Chiadmi, M. (deposition date: 2007-12-04, release date: 2008-08-12, Last modification date: 2023-11-01)
Primary citation	Gabison, L.,Prange, T.,Colloc'h, N.,El Hajji, M.,Castro, B.,Chiadmi, M. Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications Bmc Struct.Biol., 8:32-32, 2008 Cited by PubMed Abstract: Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric interfaces. PubMed: 18638417 DOI: 10.1186/1472-6807-8-32 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation