Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004853 | molecular_function | uroporphyrinogen decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006778 | biological_process | porphyrin-containing compound metabolic process |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006784 | biological_process | heme A biosynthetic process |
| A | 0006785 | biological_process | heme B biosynthetic process |
| A | 0006787 | biological_process | porphyrin-containing compound catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0042168 | biological_process | heme metabolic process |
| A | 0048034 | biological_process | heme O biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE 1CP A 368 |
| Chain | Residue |
| A | ARG37 |
| A | MET100 |
| A | PRO106 |
| A | PHE154 |
| A | TYR164 |
| A | GLY170 |
| A | PHE217 |
| A | SER219 |
| A | HIS339 |
| A | BME9500 |
| A | HOH9548 |
| A | ALA39 |
| A | HOH9612 |
| A | HOH9617 |
| A | HOH9628 |
| A | HOH9663 |
| A | HOH9693 |
| A | HOH9731 |
| A | HOH9771 |
| A | HOH9783 |
| A | HOH9788 |
| A | HOH9823 |
| A | ARG41 |
| A | HOH9838 |
| A | HOH9859 |
| A | PHE46 |
| A | PHE55 |
| A | PHE84 |
| A | SER85 |
| A | GLU86 |
| A | ILE87 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME A 9500 |
| Chain | Residue |
| A | ARG37 |
| A | 1CP368 |
| A | HOH9881 |
| A | HOH9882 |
Functional Information from PROSITE/UniProt
| site_id | PS00906 |
| Number of Residues | 10 |
| Details | UROD_1 Uroporphyrinogen decarboxylase signature 1. PVWCMRQAGR |
| Chain | Residue | Details |
| A | PRO32-ARG41 | |
| site_id | PS00907 |
| Number of Residues | 17 |
| Details | UROD_2 Uroporphyrinogen decarboxylase signature 2. IGFAGaPWTLmtYmv.EG |
| Chain | Residue | Details |
| A | ILE152-GLY168 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS339 | |
| A | ARG37 | |
| A | PHE55 | |
| A | SER85 | |
| A | GLU86 | |
| A | TYR164 | |
| A | SER219 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | GLU86 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 914 |
| Chain | Residue | Details |
| A | ARG37 | proton shuttle (general acid/base) |
| A | ARG41 | electrostatic stabiliser |
| A | ARG50 | proton shuttle (general acid/base) |
| A | GLU86 | enhance reactivity, modifies pKa, transition state stabiliser |
| A | TYR164 | electrostatic stabiliser |
