1R15
Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003953 | molecular_function | NAD+ nucleosidase activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0007338 | biological_process | single fertilization |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
A | 0030890 | biological_process | positive regulation of B cell proliferation |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
B | 0003953 | molecular_function | NAD+ nucleosidase activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0007338 | biological_process | single fertilization |
B | 0016020 | cellular_component | membrane |
B | 0016740 | molecular_function | transferase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
B | 0030890 | biological_process | positive regulation of B cell proliferation |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
C | 0003953 | molecular_function | NAD+ nucleosidase activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0007338 | biological_process | single fertilization |
C | 0016020 | cellular_component | membrane |
C | 0016740 | molecular_function | transferase activity |
C | 0016787 | molecular_function | hydrolase activity |
C | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
C | 0030890 | biological_process | positive regulation of B cell proliferation |
C | 0031410 | cellular_component | cytoplasmic vesicle |
C | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
D | 0003953 | molecular_function | NAD+ nucleosidase activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0007338 | biological_process | single fertilization |
D | 0016020 | cellular_component | membrane |
D | 0016740 | molecular_function | transferase activity |
D | 0016787 | molecular_function | hydrolase activity |
D | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
D | 0030890 | biological_process | positive regulation of B cell proliferation |
D | 0031410 | cellular_component | cytoplasmic vesicle |
D | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
E | 0003953 | molecular_function | NAD+ nucleosidase activity |
E | 0005886 | cellular_component | plasma membrane |
E | 0007338 | biological_process | single fertilization |
E | 0016020 | cellular_component | membrane |
E | 0016740 | molecular_function | transferase activity |
E | 0016787 | molecular_function | hydrolase activity |
E | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
E | 0030890 | biological_process | positive regulation of B cell proliferation |
E | 0031410 | cellular_component | cytoplasmic vesicle |
E | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
F | 0003953 | molecular_function | NAD+ nucleosidase activity |
F | 0005886 | cellular_component | plasma membrane |
F | 0007338 | biological_process | single fertilization |
F | 0016020 | cellular_component | membrane |
F | 0016740 | molecular_function | transferase activity |
F | 0016787 | molecular_function | hydrolase activity |
F | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
F | 0030890 | biological_process | positive regulation of B cell proliferation |
F | 0031410 | cellular_component | cytoplasmic vesicle |
F | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
G | 0003953 | molecular_function | NAD+ nucleosidase activity |
G | 0005886 | cellular_component | plasma membrane |
G | 0007338 | biological_process | single fertilization |
G | 0016020 | cellular_component | membrane |
G | 0016740 | molecular_function | transferase activity |
G | 0016787 | molecular_function | hydrolase activity |
G | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
G | 0030890 | biological_process | positive regulation of B cell proliferation |
G | 0031410 | cellular_component | cytoplasmic vesicle |
G | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
H | 0003953 | molecular_function | NAD+ nucleosidase activity |
H | 0005886 | cellular_component | plasma membrane |
H | 0007338 | biological_process | single fertilization |
H | 0016020 | cellular_component | membrane |
H | 0016740 | molecular_function | transferase activity |
H | 0016787 | molecular_function | hydrolase activity |
H | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
H | 0030890 | biological_process | positive regulation of B cell proliferation |
H | 0031410 | cellular_component | cytoplasmic vesicle |
H | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NCA A 319 |
Chain | Residue |
A | GLU98 |
A | SER108 |
A | TRP140 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NCA B 329 |
Chain | Residue |
B | GLU98 |
B | TRP140 |
B | N1179 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NCA C 339 |
Chain | Residue |
C | TRP140 |
C | GLU98 |
C | ASN107 |
C | SER108 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NCA D 349 |
Chain | Residue |
D | GLU98 |
D | ASN107 |
D | TRP140 |
D | N1179 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NCA H 389 |
Chain | Residue |
H | GLU98 |
H | ASN107 |
H | SER108 |
H | TRP140 |
H | N1179 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NCA B 429 |
Chain | Residue |
B | VAL110 |
B | TRP111 |
B | ARG136 |
B | PHE139 |
B | TRP140 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NCA D 449 |
Chain | Residue |
D | VAL110 |
D | TRP111 |
D | ARG136 |
D | PHE139 |
D | TRP140 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NCA F 469 |
Chain | Residue |
F | TRP111 |
F | ARG136 |
F | PHE139 |
F | TRP140 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NCA H 489 |
Chain | Residue |
H | TRP111 |
H | ARG136 |
H | PHE139 |
H | TRP140 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NCA G 479 |
Chain | Residue |
G | TRP111 |
G | ARG136 |
G | PHE139 |
G | TRP140 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NCA E 459 |
Chain | Residue |
E | VAL110 |
E | TRP111 |
E | TRP140 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NCA C 439 |
Chain | Residue |
C | TRP111 |
C | ARG136 |
C | PHE139 |
C | TRP140 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NCA A 419 |
Chain | Residue |
A | VAL110 |
A | TRP111 |
A | PHE139 |
A | TRP140 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NCA G 379 |
Chain | Residue |
G | GLU98 |
G | ASN107 |
G | SER108 |
G | TRP140 |
G | N1179 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NCA F 369 |
Chain | Residue |
F | GLU98 |
F | ASN107 |
F | N1179 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NCA E 359 |
Chain | Residue |
E | GLU98 |
E | ASN107 |
E | N1179 |
site_id | BC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE N A 1179 |
Chain | Residue |
A | TRP77 |
A | SER78 |
A | GLY79 |
A | LEU97 |
A | SER173 |
A | PHE174 |
A | GLU179 |
site_id | BC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE N B 1179 |
Chain | Residue |
B | TRP77 |
B | SER78 |
B | GLY79 |
B | LEU97 |
B | SER173 |
B | PHE174 |
B | GLU179 |
B | NCA329 |
site_id | CC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE N C 1179 |
Chain | Residue |
C | TRP77 |
C | SER78 |
C | GLY79 |
C | LEU97 |
C | SER173 |
C | PHE174 |
C | GLU179 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE N D 1179 |
Chain | Residue |
D | TRP77 |
D | SER78 |
D | GLY79 |
D | LEU97 |
D | SER173 |
D | PHE174 |
D | GLU179 |
D | NCA349 |
site_id | CC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE N E 1179 |
Chain | Residue |
E | PHE174 |
E | GLU179 |
E | NCA359 |
E | TRP77 |
E | SER78 |
E | GLY79 |
E | LEU97 |
E | SER144 |
E | SER173 |
site_id | CC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE N F 1179 |
Chain | Residue |
F | TRP77 |
F | SER78 |
F | GLY79 |
F | LEU97 |
F | SER173 |
F | PHE174 |
F | GLU179 |
F | NCA369 |
site_id | CC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE N G 1179 |
Chain | Residue |
G | TRP77 |
G | SER78 |
G | GLY79 |
G | LEU97 |
G | SER173 |
G | PHE174 |
G | GLU179 |
G | NCA379 |
site_id | CC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE N H 1179 |
Chain | Residue |
H | TRP77 |
H | SER78 |
H | GLY79 |
H | LEU97 |
H | SER144 |
H | SER173 |
H | PHE174 |
H | GLU179 |
H | NCA389 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
A | GLU98 | |
A | GLU179 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
B | GLU98 | |
B | GLU179 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
C | GLU98 | |
C | GLU179 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
D | GLU98 | |
D | GLU179 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
E | GLU98 | |
E | GLU179 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
F | GLU98 | |
F | GLU179 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
G | GLU98 | |
G | GLU179 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1r16 |
Chain | Residue | Details |
H | GLU98 | |
H | GLU179 |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
A | GLU98 | electrostatic stabiliser |
A | PHE174 | hydrophobic interaction |
A | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
B | GLU98 | electrostatic stabiliser |
B | PHE174 | hydrophobic interaction |
B | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
C | GLU98 | electrostatic stabiliser |
C | PHE174 | hydrophobic interaction |
C | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
D | GLU98 | electrostatic stabiliser |
D | PHE174 | hydrophobic interaction |
D | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA5 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
E | GLU98 | electrostatic stabiliser |
E | PHE174 | hydrophobic interaction |
E | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA6 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
F | GLU98 | electrostatic stabiliser |
F | PHE174 | hydrophobic interaction |
F | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA7 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
G | GLU98 | electrostatic stabiliser |
G | PHE174 | hydrophobic interaction |
G | GLU179 | covalent catalysis, covalently attached, nucleophile |
site_id | MCSA8 |
Number of Residues | 3 |
Details | M-CSA 607 |
Chain | Residue | Details |
H | GLU98 | electrostatic stabiliser |
H | PHE174 | hydrophobic interaction |
H | GLU179 | covalent catalysis, covalently attached, nucleophile |