1R15
Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003953 | molecular_function | NAD+ nucleosidase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007338 | biological_process | single fertilization |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| A | 0030890 | biological_process | positive regulation of B cell proliferation |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| B | 0003953 | molecular_function | NAD+ nucleosidase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007338 | biological_process | single fertilization |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| B | 0030890 | biological_process | positive regulation of B cell proliferation |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| C | 0003953 | molecular_function | NAD+ nucleosidase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007338 | biological_process | single fertilization |
| C | 0016020 | cellular_component | membrane |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| C | 0030890 | biological_process | positive regulation of B cell proliferation |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| D | 0003953 | molecular_function | NAD+ nucleosidase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0007338 | biological_process | single fertilization |
| D | 0016020 | cellular_component | membrane |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| D | 0030890 | biological_process | positive regulation of B cell proliferation |
| D | 0031410 | cellular_component | cytoplasmic vesicle |
| D | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| E | 0003953 | molecular_function | NAD+ nucleosidase activity |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0007338 | biological_process | single fertilization |
| E | 0016020 | cellular_component | membrane |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| E | 0030890 | biological_process | positive regulation of B cell proliferation |
| E | 0031410 | cellular_component | cytoplasmic vesicle |
| E | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| F | 0003953 | molecular_function | NAD+ nucleosidase activity |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0007338 | biological_process | single fertilization |
| F | 0016020 | cellular_component | membrane |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| F | 0030890 | biological_process | positive regulation of B cell proliferation |
| F | 0031410 | cellular_component | cytoplasmic vesicle |
| F | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| G | 0003953 | molecular_function | NAD+ nucleosidase activity |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0007338 | biological_process | single fertilization |
| G | 0016020 | cellular_component | membrane |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| G | 0030890 | biological_process | positive regulation of B cell proliferation |
| G | 0031410 | cellular_component | cytoplasmic vesicle |
| G | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| H | 0003953 | molecular_function | NAD+ nucleosidase activity |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0007338 | biological_process | single fertilization |
| H | 0016020 | cellular_component | membrane |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| H | 0030890 | biological_process | positive regulation of B cell proliferation |
| H | 0031410 | cellular_component | cytoplasmic vesicle |
| H | 0061809 | molecular_function | NAD+ nucleotidase, cyclic ADP-ribose generating |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NCA A 319 |
| Chain | Residue |
| A | GLU98 |
| A | SER108 |
| A | TRP140 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NCA B 329 |
| Chain | Residue |
| B | GLU98 |
| B | TRP140 |
| B | N1179 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NCA C 339 |
| Chain | Residue |
| C | TRP140 |
| C | GLU98 |
| C | ASN107 |
| C | SER108 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NCA D 349 |
| Chain | Residue |
| D | GLU98 |
| D | ASN107 |
| D | TRP140 |
| D | N1179 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NCA H 389 |
| Chain | Residue |
| H | GLU98 |
| H | ASN107 |
| H | SER108 |
| H | TRP140 |
| H | N1179 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NCA B 429 |
| Chain | Residue |
| B | VAL110 |
| B | TRP111 |
| B | ARG136 |
| B | PHE139 |
| B | TRP140 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NCA D 449 |
| Chain | Residue |
| D | VAL110 |
| D | TRP111 |
| D | ARG136 |
| D | PHE139 |
| D | TRP140 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NCA F 469 |
| Chain | Residue |
| F | TRP111 |
| F | ARG136 |
| F | PHE139 |
| F | TRP140 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NCA H 489 |
| Chain | Residue |
| H | TRP111 |
| H | ARG136 |
| H | PHE139 |
| H | TRP140 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NCA G 479 |
| Chain | Residue |
| G | TRP111 |
| G | ARG136 |
| G | PHE139 |
| G | TRP140 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NCA E 459 |
| Chain | Residue |
| E | VAL110 |
| E | TRP111 |
| E | TRP140 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NCA C 439 |
| Chain | Residue |
| C | TRP111 |
| C | ARG136 |
| C | PHE139 |
| C | TRP140 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NCA A 419 |
| Chain | Residue |
| A | VAL110 |
| A | TRP111 |
| A | PHE139 |
| A | TRP140 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NCA G 379 |
| Chain | Residue |
| G | GLU98 |
| G | ASN107 |
| G | SER108 |
| G | TRP140 |
| G | N1179 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NCA F 369 |
| Chain | Residue |
| F | GLU98 |
| F | ASN107 |
| F | N1179 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NCA E 359 |
| Chain | Residue |
| E | GLU98 |
| E | ASN107 |
| E | N1179 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE N A 1179 |
| Chain | Residue |
| A | TRP77 |
| A | SER78 |
| A | GLY79 |
| A | LEU97 |
| A | SER173 |
| A | PHE174 |
| A | GLU179 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE N B 1179 |
| Chain | Residue |
| B | TRP77 |
| B | SER78 |
| B | GLY79 |
| B | LEU97 |
| B | SER173 |
| B | PHE174 |
| B | GLU179 |
| B | NCA329 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE N C 1179 |
| Chain | Residue |
| C | TRP77 |
| C | SER78 |
| C | GLY79 |
| C | LEU97 |
| C | SER173 |
| C | PHE174 |
| C | GLU179 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE N D 1179 |
| Chain | Residue |
| D | TRP77 |
| D | SER78 |
| D | GLY79 |
| D | LEU97 |
| D | SER173 |
| D | PHE174 |
| D | GLU179 |
| D | NCA349 |
| site_id | CC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE N E 1179 |
| Chain | Residue |
| E | PHE174 |
| E | GLU179 |
| E | NCA359 |
| E | TRP77 |
| E | SER78 |
| E | GLY79 |
| E | LEU97 |
| E | SER144 |
| E | SER173 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE N F 1179 |
| Chain | Residue |
| F | TRP77 |
| F | SER78 |
| F | GLY79 |
| F | LEU97 |
| F | SER173 |
| F | PHE174 |
| F | GLU179 |
| F | NCA369 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE N G 1179 |
| Chain | Residue |
| G | TRP77 |
| G | SER78 |
| G | GLY79 |
| G | LEU97 |
| G | SER173 |
| G | PHE174 |
| G | GLU179 |
| G | NCA379 |
| site_id | CC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE N H 1179 |
| Chain | Residue |
| H | TRP77 |
| H | SER78 |
| H | GLY79 |
| H | LEU97 |
| H | SER144 |
| H | SER173 |
| H | PHE174 |
| H | GLU179 |
| H | NCA389 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| A | GLU98 | electrostatic stabiliser |
| A | PHE174 | hydrophobic interaction |
| A | GLU179 | covalent catalysis, covalently attached, nucleophile |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| B | GLU98 | electrostatic stabiliser |
| B | PHE174 | hydrophobic interaction |
| B | GLU179 | covalent catalysis, covalently attached, nucleophile |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| C | GLU98 | electrostatic stabiliser |
| C | PHE174 | hydrophobic interaction |
| C | GLU179 | covalent catalysis, covalently attached, nucleophile |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| D | GLU98 | electrostatic stabiliser |
| D | PHE174 | hydrophobic interaction |
| D | GLU179 | covalent catalysis, covalently attached, nucleophile |
| site_id | MCSA5 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| E | GLU98 | electrostatic stabiliser |
| E | PHE174 | hydrophobic interaction |
| E | GLU179 | covalent catalysis, covalently attached, nucleophile |
| site_id | MCSA6 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| F | GLU98 | electrostatic stabiliser |
| F | PHE174 | hydrophobic interaction |
| F | GLU179 | covalent catalysis, covalently attached, nucleophile |
| site_id | MCSA7 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| G | GLU98 | electrostatic stabiliser |
| G | PHE174 | hydrophobic interaction |
| G | GLU179 | covalent catalysis, covalently attached, nucleophile |
| site_id | MCSA8 |
| Number of Residues | 3 |
| Details | M-CSA 607 |
| Chain | Residue | Details |
| H | GLU98 | electrostatic stabiliser |
| H | PHE174 | hydrophobic interaction |
| H | GLU179 | covalent catalysis, covalently attached, nucleophile |
