1QXL
Crystal structure of Adenosine deaminase complexed with FR235380
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004000 | molecular_function | adenosine deaminase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006154 | biological_process | adenosine catabolic process |
| A | 0007155 | biological_process | cell adhesion |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009168 | biological_process | purine ribonucleoside monophosphate biosynthetic process |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019239 | molecular_function | deaminase activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0042110 | biological_process | T cell activation |
| A | 0043103 | biological_process | hypoxanthine salvage |
| A | 0045187 | biological_process | regulation of circadian sleep/wake cycle, sleep |
| A | 0046103 | biological_process | inosine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046936 | molecular_function | 2'-deoxyadenosine deaminase activity |
| A | 0060169 | biological_process | negative regulation of adenosine receptor signaling pathway |
| A | 0060205 | cellular_component | cytoplasmic vesicle lumen |
| A | 0070161 | cellular_component | anchoring junction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | HIS15 |
| A | HIS17 |
| A | HIS214 |
| A | ASP295 |
| A | HOH1078 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FR8 A 1001 |
| Chain | Residue |
| A | GLY184 |
| A | ASP185 |
| A | GLU217 |
| A | THR269 |
| A | ASP296 |
| A | HOH1002 |
| A | HOH1004 |
| A | HOH1072 |
| A | HIS17 |
| A | ASP19 |
| A | LEU56 |
| A | PHE65 |
Functional Information from PROSITE/UniProt
| site_id | PS00485 |
| Number of Residues | 7 |
| Details | A_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP |
| Chain | Residue | Details |
| A | SER291-PRO297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P03958","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12554940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14709046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15139750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15213224","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15239652","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15695814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16033254","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16060665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18549808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12554940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14709046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15139750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15239652","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16033254","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16060665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18549808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QXL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14709046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16060665","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WXY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12554940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14709046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15139750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15239652","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16033254","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18549808","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QXL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for interaction with adenosine receptors and increasing their affinity for agonists","evidences":[{"source":"UniProtKB","id":"P00813","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"UniProtKB","id":"P03958","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P00813","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a4l |
| Chain | Residue | Details |
| A | HIS238 | |
| A | TYR240 | |
| A | GLU217 | |
| A | ASP295 |
