1QHF
YEAST PHOSPHOGLYCERATE MUTASE-3PG COMPLEX STRUCTURE TO 1.7 A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004619 | molecular_function | phosphoglycerate mutase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016868 | molecular_function | intramolecular phosphotransferase activity |
| A | 0046538 | molecular_function | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004619 | molecular_function | phosphoglycerate mutase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016868 | molecular_function | intramolecular phosphotransferase activity |
| B | 0046538 | molecular_function | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 248 |
| Chain | Residue |
| A | 3PG252 |
| A | HOH331 |
| A | HIS8 |
| A | SER11 |
| A | ASN14 |
| A | THR20 |
| A | ARG59 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 249 |
| Chain | Residue |
| B | HIS8 |
| B | SER11 |
| B | ASN14 |
| B | THR20 |
| B | 3PG253 |
| B | HOH348 |
| B | HOH349 |
| B | HOH352 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 250 |
| Chain | Residue |
| B | TYR89 |
| B | ARG113 |
| B | HOH347 |
| B | HOH369 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 251 |
| Chain | Residue |
| A | PHE19 |
| A | TYR89 |
| A | LYS97 |
| A | ARG113 |
| A | VAL240 |
| A | HOH286 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 3PG A 252 |
| Chain | Residue |
| A | ARG7 |
| A | HIS8 |
| A | GLY9 |
| A | GLN10 |
| A | SER11 |
| A | ASN14 |
| A | THR20 |
| A | ARG59 |
| A | THR207 |
| A | SO4248 |
| A | HOH331 |
| A | HOH345 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 3PG B 253 |
| Chain | Residue |
| B | ARG7 |
| B | HIS8 |
| B | GLY9 |
| B | GLN10 |
| B | SER11 |
| B | ASN14 |
| B | THR20 |
| B | ARG59 |
| B | THR207 |
| B | SO4249 |
| B | HOH348 |
| B | HOH349 |
| B | HOH352 |
| site_id | PGA |
| Number of Residues | 2 |
| Details | 3PG BINDING SITE |
| Chain | Residue |
| A | HIS8 |
| A | HIS181 |
| site_id | PGB |
| Number of Residues | 2 |
| Details | 3PG BINDING SITE |
| Chain | Residue |
| B | HIS8 |
| B | HIS181 |
Functional Information from PROSITE/UniProt
| site_id | PS00175 |
| Number of Residues | 10 |
| Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LvRHGQsEwN |
| Chain | Residue | Details |
| A | LEU5-ASN14 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000269|PubMed:10064712, ECO:0000269|PubMed:10531478, ECO:0000269|PubMed:6115412, ECO:0000269|PubMed:9512715 |
| Chain | Residue | Details |
| A | GLY9 | |
| B | GLY9 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:10064712 |
| Chain | Residue | Details |
| A | ARG87 | |
| B | ARG87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10369755, ECO:0000269|PubMed:10531478, ECO:0000269|PubMed:6115412 |
| Chain | Residue | Details |
| A | HIS8 | |
| B | HIS8 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10369755, ECO:0000269|PubMed:10531478 |
| Chain | Residue | Details |
| A | GLY21 | |
| B | GLY21 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10531478 |
| Chain | Residue | Details |
| A | ALA60 | |
| B | ALA60 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10369755, ECO:0000269|PubMed:6115412 |
| Chain | Residue | Details |
| A | ARG87 | |
| A | ASN183 | |
| B | ARG87 | |
| B | ASN183 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10369755 |
| Chain | Residue | Details |
| A | ALA98 | |
| A | ARG114 | |
| B | ALA98 | |
| B | ARG114 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:10064712 |
| Chain | Residue | Details |
| A | GLY182 | |
| B | GLY182 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
| Chain | Residue | Details |
| A | GLU12 | |
| A | LEU185 | |
| B | GLU12 | |
| B | LEU185 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | PRO49 | |
| B | PRO49 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | PHE116 | |
| B | PHE116 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER127 | |
| B | SER127 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | PRO128 | |
| B | PRO128 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | ASP197 | |
| B | ASP197 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 14 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | GLY31 | |
| B | LEU57 | |
| B | ALA71 | |
| B | TYR139 | |
| B | THR175 | |
| B | HIS191 | |
| A | LEU57 | |
| A | ALA71 | |
| A | TYR139 | |
| A | THR175 | |
| A | HIS191 | |
| B | GLY31 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 504 |
| Chain | Residue | Details |
| A | GLY9 | covalent catalysis |
| A | ALA60 | electrostatic stabiliser |
| A | ARG87 | proton donor, proton shuttle (general acid/base) |
| A | GLY182 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 504 |
| Chain | Residue | Details |
| B | GLY9 | covalent catalysis |
| B | ALA60 | electrostatic stabiliser |
| B | ARG87 | proton donor, proton shuttle (general acid/base) |
| B | GLY182 | electrostatic stabiliser |
