1QFW
TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005796 | cellular_component | Golgi lumen |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009755 | biological_process | hormone-mediated signaling pathway |
| A | 0010469 | biological_process | regulation of signaling receptor activity |
| A | 0010893 | biological_process | positive regulation of steroid biosynthetic process |
| A | 0016913 | molecular_function | follicle-stimulating hormone activity |
| A | 0016914 | cellular_component | follicle-stimulating hormone complex |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0042699 | biological_process | follicle-stimulating hormone signaling pathway |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0061696 | cellular_component | pituitary gonadotropin complex |
| B | 0005102 | molecular_function | signaling receptor binding |
| B | 0005179 | molecular_function | hormone activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006915 | biological_process | apoptotic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007267 | biological_process | cell-cell signaling |
| B | 0007292 | biological_process | female gamete generation |
| B | 0009755 | biological_process | hormone-mediated signaling pathway |
| B | 0061696 | cellular_component | pituitary gonadotropin complex |
| H | 0002250 | biological_process | adaptive immune response |
| H | 0002376 | biological_process | immune system process |
| H | 0003823 | molecular_function | antigen binding |
| H | 0005576 | cellular_component | extracellular region |
| H | 0016064 | biological_process | immunoglobulin mediated immune response |
| H | 0019814 | cellular_component | immunoglobulin complex |
| I | 0002250 | biological_process | adaptive immune response |
| I | 0002376 | biological_process | immune system process |
| I | 0003823 | molecular_function | antigen binding |
| I | 0005576 | cellular_component | extracellular region |
| I | 0016064 | biological_process | immunoglobulin mediated immune response |
| I | 0019814 | cellular_component | immunoglobulin complex |
| L | 0002250 | biological_process | adaptive immune response |
| L | 0002376 | biological_process | immune system process |
| L | 0005576 | cellular_component | extracellular region |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0006955 | biological_process | immune response |
| L | 0019814 | cellular_component | immunoglobulin complex |
| M | 0002250 | biological_process | adaptive immune response |
| M | 0002376 | biological_process | immune system process |
| M | 0005576 | cellular_component | extracellular region |
| M | 0005886 | cellular_component | plasma membrane |
| M | 0006955 | biological_process | immune response |
| M | 0019814 | cellular_component | immunoglobulin complex |
Functional Information from PROSITE/UniProt
| site_id | PS00261 |
| Number of Residues | 7 |
| Details | GLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCpT |
| Chain | Residue | Details |
| B | CYS34-THR40 |
| site_id | PS00689 |
| Number of Residues | 28 |
| Details | GLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. AVAlsCqCalCrrstTDCggpkdh..PltC |
| Chain | Residue | Details |
| B | ALA83-CYS110 |
| site_id | PS00779 |
| Number of Residues | 13 |
| Details | GLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP |
| Chain | Residue | Details |
| A | CYS28-PRO40 |
| site_id | PS00780 |
| Number of Residues | 14 |
| Details | GLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK |
| Chain | Residue | Details |
| A | ASN78-LYS91 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000036","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000037","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000042","evidences":[{"source":"PDB","id":"1HRP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000043","evidences":[{"source":"PDB","id":"1HRP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 73 |
| Details | Region: {"description":"Framework-1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 54 |
| Details | Region: {"description":"Framework-2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Region: {"description":"Complementarity-determining-2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 93 |
| Details | Region: {"description":"Framework-3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | Region: {"description":"Framework-4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Region: {"description":"Complementarity-determining-1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Region: {"description":"Complementarity-determining-3"} |
| Chain | Residue | Details |
