1Q3V

Crystal structure of a wild-type Cre recombinase-loxP synapse: phosphotyrosine covalent intermediate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0006310	biological_process	DNA recombination
A	0015074	biological_process	DNA integration
B	0003677	molecular_function	DNA binding
B	0006310	biological_process	DNA recombination
B	0015074	biological_process	DNA integration
E	0003677	molecular_function	DNA binding
E	0006310	biological_process	DNA recombination
E	0015074	biological_process	DNA integration
F	0003677	molecular_function	DNA binding
F	0006310	biological_process	DNA recombination
F	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 344

Chain	Residue
A	HIS40
A	LYS43

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 345

Chain	Residue
A	HIS269

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 347

Chain	Residue
A	MET149
A	ASP157
A	ASN160
F	ARG24

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 348

Chain	Residue
A	SER330
A	GLU331

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 310

Chain	Residue
D	DA105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	85
Details	Domain: {"description":"Core-binding (CB)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01248","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	832
Details	Domain: {"description":"Tyr recombinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01246","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01246","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"O-(3'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01246","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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