1PZM
Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0043101 | biological_process | purine-containing compound salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0043101 | biological_process | purine-containing compound salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 5GP A 301 |
| Chain | Residue |
| A | ASP126 |
| A | PHE178 |
| A | VAL179 |
| A | MET184 |
| A | ASP185 |
| A | HOH321 |
| A | HOH378 |
| A | HOH403 |
| A | HOH408 |
| A | ILE127 |
| A | ASP129 |
| A | SER130 |
| A | ALA131 |
| A | ILE132 |
| A | THR133 |
| A | LYS157 |
| A | ALA177 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 5GP B 302 |
| Chain | Residue |
| B | ASN118 |
| B | ASP126 |
| B | ILE127 |
| B | ASP129 |
| B | SER130 |
| B | ALA131 |
| B | ILE132 |
| B | THR133 |
| B | LYS157 |
| B | ALA177 |
| B | PHE178 |
| B | VAL179 |
| B | ASP185 |
| B | HOH303 |
| B | HOH337 |
| B | HOH352 |
| B | HOH354 |
| B | HOH376 |
| B | HOH429 |
| B | HOH436 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. IMLVEDIVDSAiT |
| Chain | Residue | Details |
| A | ILE121-THR133 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | ASP126 | |
| A | ASP129 | |
| A | GLU125 | |
| A | LYS157 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | ASP126 | |
| B | ASP129 | |
| B | GLU125 | |
| B | LYS157 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | ASP126 | |
| A | ARG161 | |
| A | ASP129 | |
| A | GLU125 | |
| A | LYS157 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | ASP126 | |
| B | ARG161 | |
| B | ASP129 | |
| B | GLU125 | |
| B | LYS157 |
