1PX5
Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001730 | molecular_function | 2'-5'-oligoadenylate synthetase activity |
A | 0003723 | molecular_function | RNA binding |
A | 0003725 | molecular_function | double-stranded RNA binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005829 | cellular_component | cytosol |
A | 0016020 | cellular_component | membrane |
A | 0016779 | molecular_function | nucleotidyltransferase activity |
A | 0045071 | biological_process | negative regulation of viral genome replication |
A | 0045087 | biological_process | innate immune response |
A | 0046872 | molecular_function | metal ion binding |
A | 0051607 | biological_process | defense response to virus |
A | 0060700 | biological_process | regulation of ribonuclease activity |
A | 1904188 | biological_process | negative regulation of transformation of host cell by virus |
B | 0001730 | molecular_function | 2'-5'-oligoadenylate synthetase activity |
B | 0003723 | molecular_function | RNA binding |
B | 0003725 | molecular_function | double-stranded RNA binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005829 | cellular_component | cytosol |
B | 0016020 | cellular_component | membrane |
B | 0016779 | molecular_function | nucleotidyltransferase activity |
B | 0045071 | biological_process | negative regulation of viral genome replication |
B | 0045087 | biological_process | innate immune response |
B | 0046872 | molecular_function | metal ion binding |
B | 0051607 | biological_process | defense response to virus |
B | 0060700 | biological_process | regulation of ribonuclease activity |
B | 1904188 | biological_process | negative regulation of transformation of host cell by virus |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 A 801 |
Chain | Residue |
A | ARG103 |
A | HOH986 |
A | ALA107 |
A | ARG110 |
A | LYS246 |
A | HOH833 |
A | HOH835 |
A | HOH890 |
A | HOH928 |
A | HOH937 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 802 |
Chain | Residue |
B | GLN46 |
B | ARG53 |
B | LYS246 |
B | HOH894 |
B | HOH1035 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 803 |
Chain | Residue |
A | ARG295 |
A | HOH1155 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 804 |
Chain | Residue |
B | ARG38 |
B | HOH849 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00973 |
Chain | Residue | Details |
A | SER62 | |
B | GLN229 | |
A | ASP74 | |
A | ASP76 | |
A | ASP147 | |
A | GLN229 | |
B | SER62 | |
B | ASP74 | |
B | ASP76 | |
B | ASP147 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:18604630 |
Chain | Residue | Details |
A | ARG209 | |
B | ARG209 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:14636576 |
Chain | Residue | Details |
A | LYS212 | |
B | LYS212 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Interaction with dsRNA => ECO:0000250|UniProtKB:P00973 |
Chain | Residue | Details |
A | GLN157 | |
B | GLN157 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1fa0 |
Chain | Residue | Details |
A | LYS212 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1fa0 |
Chain | Residue | Details |
B | LYS212 |