1PX5
Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001730 | molecular_function | 2'-5'-oligoadenylate synthetase activity |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0016020 | cellular_component | membrane |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0045071 | biological_process | negative regulation of viral genome replication |
| A | 0051607 | biological_process | defense response to virus |
| A | 0060337 | biological_process | type I interferon-mediated signaling pathway |
| A | 0060700 | biological_process | regulation of ribonuclease activity |
| A | 0070106 | biological_process | interleukin-27-mediated signaling pathway |
| A | 0140374 | biological_process | antiviral innate immune response |
| B | 0001730 | molecular_function | 2'-5'-oligoadenylate synthetase activity |
| B | 0003725 | molecular_function | double-stranded RNA binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005829 | cellular_component | cytosol |
| B | 0016020 | cellular_component | membrane |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0045071 | biological_process | negative regulation of viral genome replication |
| B | 0051607 | biological_process | defense response to virus |
| B | 0060337 | biological_process | type I interferon-mediated signaling pathway |
| B | 0060700 | biological_process | regulation of ribonuclease activity |
| B | 0070106 | biological_process | interleukin-27-mediated signaling pathway |
| B | 0140374 | biological_process | antiviral innate immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 801 |
| Chain | Residue |
| A | ARG103 |
| A | HOH986 |
| A | ALA107 |
| A | ARG110 |
| A | LYS246 |
| A | HOH833 |
| A | HOH835 |
| A | HOH890 |
| A | HOH928 |
| A | HOH937 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 802 |
| Chain | Residue |
| B | GLN46 |
| B | ARG53 |
| B | LYS246 |
| B | HOH894 |
| B | HOH1035 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 803 |
| Chain | Residue |
| A | ARG295 |
| A | HOH1155 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 804 |
| Chain | Residue |
| B | ARG38 |
| B | HOH849 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Region: {"description":"Interaction with dsRNA","evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18604630","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14636576","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with dsRNA","evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fa0 |
| Chain | Residue | Details |
| A | LYS212 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fa0 |
| Chain | Residue | Details |
| B | LYS212 |
