1PJA

The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0098599	molecular_function	palmitoyl hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
A	SER111

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	ASP228
A	HIS283

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN60
A	ASN206
A	ASN245
A	ASN289

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12855696

Chain	Residue	Details
A	ASN190

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 523

Chain	Residue	Details
A	LEU45	electrostatic stabiliser
A	SER111	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
A	GLN112	electrostatic stabiliser
A	ASP228	electrostatic stabiliser, increase basicity
A	HIS283	proton acceptor, proton donor

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