1PGR

2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005125	molecular_function	cytokine activity
A	0005130	molecular_function	granulocyte colony-stimulating factor receptor binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006955	biological_process	immune response
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0019899	molecular_function	enzyme binding
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0030851	biological_process	granulocyte differentiation
A	0038158	biological_process	granulocyte colony-stimulating factor signaling pathway
A	0043202	cellular_component	lysosomal lumen
A	0045471	biological_process	response to ethanol
A	0045639	biological_process	positive regulation of myeloid cell differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071345	biological_process	cellular response to cytokine stimulus
A	0071682	cellular_component	endocytic vesicle lumen
A	0110053	biological_process	regulation of actin filament organization
C	0005102	molecular_function	signaling receptor binding
C	0005125	molecular_function	cytokine activity
C	0005130	molecular_function	granulocyte colony-stimulating factor receptor binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006955	biological_process	immune response
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0019899	molecular_function	enzyme binding
C	0030838	biological_process	positive regulation of actin filament polymerization
C	0030851	biological_process	granulocyte differentiation
C	0038158	biological_process	granulocyte colony-stimulating factor signaling pathway
C	0043202	cellular_component	lysosomal lumen
C	0045471	biological_process	response to ethanol
C	0045639	biological_process	positive regulation of myeloid cell differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071345	biological_process	cellular response to cytokine stimulus
C	0071682	cellular_component	endocytic vesicle lumen
C	0110053	biological_process	regulation of actin filament organization
E	0005102	molecular_function	signaling receptor binding
E	0005125	molecular_function	cytokine activity
E	0005130	molecular_function	granulocyte colony-stimulating factor receptor binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006955	biological_process	immune response
E	0008083	molecular_function	growth factor activity
E	0008284	biological_process	positive regulation of cell population proliferation
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0019899	molecular_function	enzyme binding
E	0030838	biological_process	positive regulation of actin filament polymerization
E	0030851	biological_process	granulocyte differentiation
E	0038158	biological_process	granulocyte colony-stimulating factor signaling pathway
E	0043202	cellular_component	lysosomal lumen
E	0045471	biological_process	response to ethanol
E	0045639	biological_process	positive regulation of myeloid cell differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
E	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0071345	biological_process	cellular response to cytokine stimulus
E	0071682	cellular_component	endocytic vesicle lumen
E	0110053	biological_process	regulation of actin filament organization
G	0005102	molecular_function	signaling receptor binding
G	0005125	molecular_function	cytokine activity
G	0005130	molecular_function	granulocyte colony-stimulating factor receptor binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006955	biological_process	immune response
G	0008083	molecular_function	growth factor activity
G	0008284	biological_process	positive regulation of cell population proliferation
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0019899	molecular_function	enzyme binding
G	0030838	biological_process	positive regulation of actin filament polymerization
G	0030851	biological_process	granulocyte differentiation
G	0038158	biological_process	granulocyte colony-stimulating factor signaling pathway
G	0043202	cellular_component	lysosomal lumen
G	0045471	biological_process	response to ethanol
G	0045639	biological_process	positive regulation of myeloid cell differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
G	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0071222	biological_process	cellular response to lipopolysaccharide
G	0071345	biological_process	cellular response to cytokine stimulus
G	0071682	cellular_component	endocytic vesicle lumen
G	0110053	biological_process	regulation of actin filament organization

Functional Information from PROSITE/UniProt

site_id	PS00254
Number of Residues	26
Details	INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CpsqalqlagClsqlhsGLflYqglL

Chain	Residue	Details
A	CYS65-LEU90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10537111

Chain	Residue	Details
B	ASN10
D	ASN10
F	ASN10
H	ASN10

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN67
B	ASN160
D	ASN67
D	ASN160
F	ASN67
F	ASN160
H	ASN67
H	ASN160

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