1NY3

Crystal structure of ADP bound to MAP KAP kinase 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0002224	biological_process	toll-like receptor signaling pathway
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004683	molecular_function	calcium/calmodulin-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0006691	biological_process	leukotriene metabolic process
A	0006954	biological_process	inflammatory response
A	0006974	biological_process	DNA damage response
A	0009931	molecular_function	calcium-dependent protein serine/threonine kinase activity
A	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032496	biological_process	response to lipopolysaccharide
A	0032675	biological_process	regulation of interleukin-6 production
A	0032680	biological_process	regulation of tumor necrosis factor production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034097	biological_process	response to cytokine
A	0035556	biological_process	intracellular signal transduction
A	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
A	0036064	cellular_component	ciliary basal body
A	0038066	biological_process	p38MAPK cascade
A	0043488	biological_process	regulation of mRNA stability
A	0044351	biological_process	macropinocytosis
A	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
A	0048255	biological_process	mRNA stabilization
A	0048839	biological_process	inner ear development
A	0051019	molecular_function	mitogen-activated protein kinase binding
A	0060907	biological_process	positive regulation of macrophage cytokine production
A	0070062	cellular_component	extracellular exosome
A	0070935	biological_process	3'-UTR-mediated mRNA stabilization
A	0106310	molecular_function	protein serine kinase activity
A	1900034	biological_process	regulation of cellular response to heat

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP A 401

Chain	Residue
A	LEU70
A	ASN191
A	ASP207
A	GLY71
A	LEU72
A	GLY73
A	ILE74
A	ALA91
A	LYS93
A	GLU139
A	LEU141

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK

Chain	Residue	Details
A	LEU70-LYS93

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY

Chain	Residue	Details
A	ILE182-TYR194

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP186
A	GLU190

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP186
A	LYS188

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP186
A	ASN191
A	LYS188

---