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1NY3

Crystal structure of ADP bound to MAP KAP kinase 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0002224biological_processtoll-like receptor signaling pathway
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004683molecular_functioncalmodulin-dependent protein kinase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0006468biological_processprotein phosphorylation
A0006691biological_processleukotriene metabolic process
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0032496biological_processresponse to lipopolysaccharide
A0032675biological_processregulation of interleukin-6 production
A0032680biological_processregulation of tumor necrosis factor production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0034097biological_processresponse to cytokine
A0035556biological_processintracellular signal transduction
A0035924biological_processcellular response to vascular endothelial growth factor stimulus
A0038066biological_processp38MAPK cascade
A0043488biological_processregulation of mRNA stability
A0044351biological_processmacropinocytosis
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048255biological_processmRNA stabilization
A0048839biological_processinner ear development
A0051019molecular_functionmitogen-activated protein kinase binding
A0060907biological_processpositive regulation of macrophage cytokine production
A0070062cellular_componentextracellular exosome
A0070935biological_process3'-UTR-mediated mRNA stabilization
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ADP A 401
ChainResidue
ALEU70
AASN191
AASP207
AGLY71
ALEU72
AGLY73
AILE74
AALA91
ALYS93
AGLU139
ALEU141

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK
ChainResidueDetails
ALEU70-LYS93

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY
ChainResidueDetails
AILE182-TYR194

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP186

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU70
ALYS93

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING:
ChainResidueDetails
AGLU139

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:8846784
ChainResidueDetails
ASER9

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:8846784
ChainResidueDetails
ATHR25

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784
ChainResidueDetails
ATHR222

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784
ChainResidueDetails
ASER272

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000250
ChainResidueDetails
ASER328

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR334

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:21131586
ChainResidueDetails
ALYS353

218853

PDB entries from 2024-04-24

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