1NY3
Crystal structure of ADP bound to MAP KAP kinase 2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000165 | biological_process | MAPK cascade |
A | 0002224 | biological_process | toll-like receptor signaling pathway |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0004683 | molecular_function | calmodulin-dependent protein kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005516 | molecular_function | calmodulin binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005813 | cellular_component | centrosome |
A | 0005829 | cellular_component | cytosol |
A | 0006468 | biological_process | protein phosphorylation |
A | 0006691 | biological_process | leukotriene metabolic process |
A | 0006954 | biological_process | inflammatory response |
A | 0006974 | biological_process | DNA damage response |
A | 0009931 | molecular_function | calcium-dependent protein serine/threonine kinase activity |
A | 0010803 | biological_process | regulation of tumor necrosis factor-mediated signaling pathway |
A | 0018105 | biological_process | peptidyl-serine phosphorylation |
A | 0032496 | biological_process | response to lipopolysaccharide |
A | 0032675 | biological_process | regulation of interleukin-6 production |
A | 0032680 | biological_process | regulation of tumor necrosis factor production |
A | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
A | 0034097 | biological_process | response to cytokine |
A | 0035556 | biological_process | intracellular signal transduction |
A | 0035924 | biological_process | cellular response to vascular endothelial growth factor stimulus |
A | 0038066 | biological_process | p38MAPK cascade |
A | 0043488 | biological_process | regulation of mRNA stability |
A | 0044351 | biological_process | macropinocytosis |
A | 0048010 | biological_process | vascular endothelial growth factor receptor signaling pathway |
A | 0048255 | biological_process | mRNA stabilization |
A | 0048839 | biological_process | inner ear development |
A | 0051019 | molecular_function | mitogen-activated protein kinase binding |
A | 0060907 | biological_process | positive regulation of macrophage cytokine production |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070935 | biological_process | 3'-UTR-mediated mRNA stabilization |
A | 0106310 | molecular_function | protein serine kinase activity |
A | 1900034 | biological_process | regulation of cellular response to heat |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ADP A 401 |
Chain | Residue |
A | LEU70 |
A | ASN191 |
A | ASP207 |
A | GLY71 |
A | LEU72 |
A | GLY73 |
A | ILE74 |
A | ALA91 |
A | LYS93 |
A | GLU139 |
A | LEU141 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK |
Chain | Residue | Details |
A | LEU70-LYS93 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY |
Chain | Residue | Details |
A | ILE182-TYR194 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | ASP186 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU70 | |
A | LYS93 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
A | GLU139 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:8846784 |
Chain | Residue | Details |
A | SER9 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:8846784 |
Chain | Residue | Details |
A | THR25 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784 |
Chain | Residue | Details |
A | THR222 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784 |
Chain | Residue | Details |
A | SER272 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250 |
Chain | Residue | Details |
A | SER328 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR334 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:21131586 |
Chain | Residue | Details |
A | LYS353 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP186 | |
A | GLU190 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP186 | |
A | LYS188 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP186 | |
A | ASN191 | |
A | LYS188 |