1NFR
Rv2002 gene product from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006706 | biological_process | steroid catabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0047044 | molecular_function | androstan-3-alpha,17-beta-diol dehydrogenase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006706 | biological_process | steroid catabolic process |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0047044 | molecular_function | androstan-3-alpha,17-beta-diol dehydrogenase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006706 | biological_process | steroid catabolic process |
| C | 0008202 | biological_process | steroid metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0047044 | molecular_function | androstan-3-alpha,17-beta-diol dehydrogenase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006706 | biological_process | steroid catabolic process |
| D | 0008202 | biological_process | steroid metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0047044 | molecular_function | androstan-3-alpha,17-beta-diol dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD A 300 |
| Chain | Residue |
| A | GLY14 |
| A | VAL62 |
| A | ASN88 |
| A | ALA89 |
| A | GLY90 |
| A | ILE91 |
| A | VAL111 |
| A | ILE138 |
| A | SER139 |
| A | SER140 |
| A | TYR153 |
| A | ARG17 |
| A | LYS157 |
| A | PRO183 |
| A | GLY184 |
| A | LEU185 |
| A | VAL186 |
| A | THR188 |
| A | PRO189 |
| A | MSE190 |
| A | THR191 |
| A | HOH611 |
| A | GLY18 |
| A | HOH779 |
| A | MSE19 |
| A | ASP38 |
| A | ILE39 |
| A | LEU40 |
| A | LEU60 |
| A | ASP61 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD B 1300 |
| Chain | Residue |
| B | GLY14 |
| B | ARG17 |
| B | GLY18 |
| B | MSE19 |
| B | ASP38 |
| B | LEU40 |
| B | LEU60 |
| B | ASP61 |
| B | VAL62 |
| B | ASN88 |
| B | ALA89 |
| B | GLY90 |
| B | ILE91 |
| B | ILE138 |
| B | SER139 |
| B | SER140 |
| B | TYR153 |
| B | LYS157 |
| B | PRO183 |
| B | GLY184 |
| B | VAL186 |
| B | THR188 |
| B | PRO189 |
| B | MSE190 |
| B | THR191 |
| B | HOH519 |
| B | HOH588 |
| B | HOH684 |
| B | HOH750 |
| site_id | AC3 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD C 2300 |
| Chain | Residue |
| C | GLY14 |
| C | ARG17 |
| C | GLY18 |
| C | MSE19 |
| C | ASP38 |
| C | LEU40 |
| C | LEU60 |
| C | ASP61 |
| C | VAL62 |
| C | ASN88 |
| C | ALA89 |
| C | GLY90 |
| C | ILE91 |
| C | ILE138 |
| C | SER139 |
| C | SER140 |
| C | TYR153 |
| C | LYS157 |
| C | PRO183 |
| C | GLY184 |
| C | LEU185 |
| C | VAL186 |
| C | THR188 |
| C | PRO189 |
| C | MSE190 |
| C | THR191 |
| C | HOH501 |
| C | HOH508 |
| C | HOH551 |
| C | HOH695 |
| C | HOH699 |
| C | HOH703 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD D 3300 |
| Chain | Residue |
| D | ASP61 |
| D | VAL62 |
| D | ASN88 |
| D | GLY90 |
| D | ILE91 |
| D | ILE138 |
| D | SER139 |
| D | SER140 |
| D | TYR153 |
| D | LYS157 |
| D | PRO183 |
| D | GLY184 |
| D | VAL186 |
| D | THR188 |
| D | PRO189 |
| D | MSE190 |
| D | THR191 |
| D | HOH527 |
| D | HOH635 |
| D | HOH667 |
| D | GLY14 |
| D | ARG17 |
| D | GLY18 |
| D | MSE19 |
| D | ASP38 |
| D | ILE39 |
| D | LEU40 |
| D | LEU60 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SieglagtvaChgYTATKFAVrGLTkSTA |
| Chain | Residue | Details |
| A | SER140-ALA168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:12524453 |
| Chain | Residue | Details |
| A | TYR153 | |
| B | TYR153 | |
| C | TYR153 | |
| D | TYR153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12524453, ECO:0007744|PDB:1NFF, ECO:0007744|PDB:1NFQ, ECO:0007744|PDB:1NFR |
| Chain | Residue | Details |
| A | ARG17 | |
| B | ASP61 | |
| B | ASN88 | |
| B | TYR153 | |
| B | LYS157 | |
| B | PRO183 | |
| C | ARG17 | |
| C | ASP38 | |
| C | ASP61 | |
| C | ASN88 | |
| C | TYR153 | |
| A | ASP38 | |
| C | LYS157 | |
| C | PRO183 | |
| D | ARG17 | |
| D | ASP38 | |
| D | ASP61 | |
| D | ASN88 | |
| D | TYR153 | |
| D | LYS157 | |
| D | PRO183 | |
| A | ASP61 | |
| A | ASN88 | |
| A | TYR153 | |
| A | LYS157 | |
| A | PRO183 | |
| B | ARG17 | |
| B | ASP38 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | GLU142 | |
| A | SER140 | |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| B | SER140 | |
| B | ASN112 | |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| C | SER140 | |
| C | ASN112 | |
| C | LYS157 | |
| C | TYR153 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| D | SER140 | |
| D | ASN112 | |
| D | LYS157 | |
| D | TYR153 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | CYS150 | |
| A | LYS157 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| B | CYS150 | |
| B | LYS157 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| C | CYS150 | |
| C | LYS157 |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| D | CYS150 | |
| D | LYS157 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| C | LYS157 | |
| C | TYR153 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| B | GLU142 | |
| B | SER140 | |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| D | LYS157 | |
| D | TYR153 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| C | GLU142 | |
| C | SER140 | |
| C | LYS157 | |
| C | TYR153 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| D | GLU142 | |
| D | SER140 | |
| D | LYS157 | |
| D | TYR153 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | SER140 | |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| B | SER140 | |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| C | SER140 | |
| C | LYS157 | |
| C | TYR153 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| D | SER140 | |
| D | LYS157 | |
| D | TYR153 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | SER140 | |
| A | ASN112 | |
| A | LYS157 | |
| A | TYR153 |
