Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NB5

Crystal structure of stefin A in complex with cathepsin H

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
I	0001533	cellular_component	cornified envelope
I	0002020	molecular_function	protease binding
I	0004866	molecular_function	endopeptidase inhibitor activity
I	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0007155	biological_process	cell adhesion
I	0010466	biological_process	negative regulation of peptidase activity
I	0018149	biological_process	peptide cross-linking
I	0030216	biological_process	keratinocyte differentiation
I	0030414	molecular_function	peptidase inhibitor activity
I	0045861	biological_process	negative regulation of proteolysis
I	0098609	biological_process	cell-cell adhesion
I	1904090	cellular_component	peptidase inhibitor complex
J	0001533	cellular_component	cornified envelope
J	0002020	molecular_function	protease binding
J	0004866	molecular_function	endopeptidase inhibitor activity
J	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
J	0005515	molecular_function	protein binding
J	0005615	cellular_component	extracellular space
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0007155	biological_process	cell adhesion
J	0010466	biological_process	negative regulation of peptidase activity
J	0018149	biological_process	peptide cross-linking
J	0030216	biological_process	keratinocyte differentiation
J	0030414	molecular_function	peptidase inhibitor activity
J	0045861	biological_process	negative regulation of proteolysis
J	0098609	biological_process	cell-cell adhesion
J	1904090	cellular_component	peptidase inhibitor complex
K	0001533	cellular_component	cornified envelope
K	0002020	molecular_function	protease binding
K	0004866	molecular_function	endopeptidase inhibitor activity
K	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
K	0005515	molecular_function	protein binding
K	0005615	cellular_component	extracellular space
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0007155	biological_process	cell adhesion
K	0010466	biological_process	negative regulation of peptidase activity
K	0018149	biological_process	peptide cross-linking
K	0030216	biological_process	keratinocyte differentiation
K	0030414	molecular_function	peptidase inhibitor activity
K	0045861	biological_process	negative regulation of proteolysis
K	0098609	biological_process	cell-cell adhesion
K	1904090	cellular_component	peptidase inhibitor complex
L	0001533	cellular_component	cornified envelope
L	0002020	molecular_function	protease binding
L	0004866	molecular_function	endopeptidase inhibitor activity
L	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
L	0005515	molecular_function	protein binding
L	0005615	cellular_component	extracellular space
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007155	biological_process	cell adhesion
L	0010466	biological_process	negative regulation of peptidase activity
L	0018149	biological_process	peptide cross-linking
L	0030216	biological_process	keratinocyte differentiation
L	0030414	molecular_function	peptidase inhibitor activity
L	0045861	biological_process	negative regulation of proteolysis
L	0098609	biological_process	cell-cell adhesion
L	1904090	cellular_component	peptidase inhibitor complex

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWTfST

Chain	Residue	Details
A	GLN19-THR30

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHAVLAVGYG

Chain	Residue	Details
A	VAL157-GLY167

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgpqWGmnGYFlI

Chain	Residue	Details
A	TYR170-ILE189

site_id	PS00287
Number of Residues	14
Details	CYSTATIN Cysteine proteases inhibitors signature. TQVVAGTNYyIKVR

Chain	Residue	Details
I	THR52-ARG65

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Reactive site

Chain	Residue	Details
I	GLY9
D	CYS25
D	HIS159
D	ASN175
J	GLY9
K	GLY9
L	GLY9
B	HIS159
B	ASN175
C	CYS25
C	HIS159
C	ASN175

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000250\|UniProtKB:P01039

Chain	Residue	Details
I	MET6
J	MET6
K	MET6
L	MET6

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 682

Chain	Residue	Details
A	GLN19	electrostatic stabiliser
A	CYS25	covalent catalysis, proton shuttle (general acid/base)
A	HIS159	electrostatic stabiliser, proton shuttle (general acid/base)

site_id	MCSA2
Number of Residues
Details	M-CSA 682

Chain	Residue	Details
B	GLN19	electrostatic stabiliser
B	CYS25	covalent catalysis, proton shuttle (general acid/base)
B	HIS159	electrostatic stabiliser, proton shuttle (general acid/base)

site_id	MCSA3
Number of Residues
Details	M-CSA 682

Chain	Residue	Details
C	GLN19	electrostatic stabiliser
C	CYS25	covalent catalysis, proton shuttle (general acid/base)
C	HIS159	electrostatic stabiliser, proton shuttle (general acid/base)

site_id	MCSA4
Number of Residues
Details	M-CSA 682

Chain	Residue	Details
D	GLN19	electrostatic stabiliser
D	CYS25	covalent catalysis, proton shuttle (general acid/base)
D	HIS159	electrostatic stabiliser, proton shuttle (general acid/base)

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)