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1N0W

Crystal structure of a RAD51-BRCA2 BRC repeat complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000150molecular_functionDNA strand exchange activity
A0000724biological_processdouble-strand break repair via homologous recombination
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0005524molecular_functionATP binding
A0006259biological_processDNA metabolic process
A0006281biological_processDNA repair
A0006310biological_processDNA recombination
A0008094molecular_functionATP-dependent activity, acting on DNA
A0016887molecular_functionATP hydrolysis activity
A0140664molecular_functionATP-dependent DNA damage sensor activity
A1990426biological_processmitotic recombination-dependent replication fork processing
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 401
ChainResidue
AGLN101
ALEU113
AGLY116
AHOH553
AHOH646

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 501
ChainResidue
AGLN135
AARG130
AGLY132
ALYS133
ATHR134

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 502
ChainResidue
AGLU154
AALA246
AHOH516
AHOH536
AHOH689

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 503
ChainResidue
AGLU124
ALEU249
AALA293
AARG299
AHOH528

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 504
ChainResidue
AILE311
AGLU324
AMSE326
AHOH694
AHOH695

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 505
ChainResidue
ATHR162
AGLU163
AALA226
ALEU227

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 506
ChainResidue
AGLN135
ATHR165
AARG170
APRO318
ACYS319

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
AGLY127

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CHEK1 => ECO:0000269|PubMed:15665856
ChainResidueDetails
ATHR309

227111

PDB entries from 2024-11-06

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