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1LKI

THE CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTION OF LEUKEMIA INHIBITORY FACTOR: IMPLICATIONS FOR RECEPTOR BINDING

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001666biological_processresponse to hypoxia
A0001974biological_processblood vessel remodeling
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005146molecular_functionleukemia inhibitory factor receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005829cellular_componentcytosol
A0006955biological_processimmune response
A0007566biological_processembryo implantation
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0010467biological_processgene expression
A0010628biological_processpositive regulation of gene expression
A0010646biological_processregulation of cell communication
A0023051biological_processregulation of signaling
A0030324biological_processlung development
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0035019biological_processsomatic stem cell population maintenance
A0043410biological_processpositive regulation of MAPK cascade
A0045595biological_processregulation of cell differentiation
A0045651biological_processpositive regulation of macrophage differentiation
A0045835biological_processnegative regulation of meiotic nuclear division
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046697biological_processdecidualization
A0046888biological_processnegative regulation of hormone secretion
A0048144biological_processfibroblast proliferation
A0048146biological_processpositive regulation of fibroblast proliferation
A0048286biological_processlung alveolus development
A0048644biological_processmuscle organ morphogenesis
A0048666biological_processneuron development
A0048711biological_processpositive regulation of astrocyte differentiation
A0048861biological_processleukemia inhibitory factor signaling pathway
A0048863biological_processstem cell differentiation
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0060135biological_processmaternal process involved in female pregnancy
A0060426biological_processlung vasculature development
A0060463biological_processlung lobe morphogenesis
A0060707biological_processtrophoblast giant cell differentiation
A0060708biological_processspongiotrophoblast differentiation
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0072108biological_processpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
A0072307biological_processregulation of metanephric nephron tubule epithelial cell differentiation
A0097696biological_processcell surface receptor signaling pathway via STAT
A0140013biological_processmeiotic nuclear division
A1904894biological_processpositive regulation of receptor signaling pathway via STAT
Functional Information from PROSITE/UniProt
site_idPS00590
Number of Residues20
DetailsLIF_OSM LIF / OSM family signature. SdkeaFQrKklgCqLLgtYK
ChainResidueDetails
ASER151-LYS170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN9
AASN34
AASN96
AASN116

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN63
AASN73

227344

PDB entries from 2024-11-13

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