Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1L9U

THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0046872	molecular_function	metal ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034062	molecular_function	5'-3' RNA polymerase activity
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006352	biological_process	DNA-templated transcription initiation
H	0006355	biological_process	regulation of DNA-templated transcription
H	0016987	molecular_function	sigma factor activity
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005737	cellular_component	cytoplasm
J	0006351	biological_process	DNA-templated transcription
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0034062	molecular_function	5'-3' RNA polymerase activity
J	0046983	molecular_function	protein dimerization activity
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005737	cellular_component	cytoplasm
K	0006351	biological_process	DNA-templated transcription
K	0016740	molecular_function	transferase activity
K	0016779	molecular_function	nucleotidyltransferase activity
K	0034062	molecular_function	5'-3' RNA polymerase activity
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0006351	biological_process	DNA-templated transcription
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0032549	molecular_function	ribonucleoside binding
L	0034062	molecular_function	5'-3' RNA polymerase activity
M	0000287	molecular_function	magnesium ion binding
M	0000428	cellular_component	DNA-directed RNA polymerase complex
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed RNA polymerase activity
M	0006351	biological_process	DNA-templated transcription
M	0008270	molecular_function	zinc ion binding
M	0016740	molecular_function	transferase activity
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034062	molecular_function	5'-3' RNA polymerase activity
M	0046872	molecular_function	metal ion binding
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed RNA polymerase activity
N	0006351	biological_process	DNA-templated transcription
N	0016740	molecular_function	transferase activity
N	0016779	molecular_function	nucleotidyltransferase activity
N	0034062	molecular_function	5'-3' RNA polymerase activity
Q	0003677	molecular_function	DNA binding
Q	0003700	molecular_function	DNA-binding transcription factor activity
Q	0006352	biological_process	DNA-templated transcription initiation
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0016987	molecular_function	sigma factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 2003

Chain	Residue
D	GLU69
D	GLY70

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN M 3003

Chain	Residue
M	GLU69
M	GLY70

Functional Information from PROSITE/UniProt

site_id	PS00716
Number of Residues	27
Details	SIGMA70_2 Sigma-70 factors family signature 2. TleEVGayfgVTrerIrQIEnkaLrkL

Chain	Residue	Details
H	THR397-LEU423

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL

Chain	Residue	Details
H	LEU202-LEU209

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV

Chain	Residue	Details
C	GLY836-VAL848

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	38
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	70
Details	Region: {"description":"Sigma-70 factor domain-1"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	140
Details	Region: {"description":"Sigma-70 factor domain-2"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	104
Details	Region: {"description":"Sigma-70 factor domain-4"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Motif: {"description":"Interaction with polymerase core subunit RpoC"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)