1L8C
STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 96 |
| Chain | Residue |
| A | HIS18 |
| A | CYS22 |
| A | CYS35 |
| A | CYS40 |
| A | LYS44 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 97 |
| Chain | Residue |
| A | HIS49 |
| A | CYS53 |
| A | CYS59 |
| A | CYS64 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 98 |
| Chain | Residue |
| A | HIS73 |
| A | CYS77 |
| A | ARG79 |
| A | CYS82 |
| A | CYS85 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 86 |
| Details | Zinc finger: {"description":"TAZ-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00203","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14594809","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Region: {"description":"CTAD","evidences":[{"source":"PubMed","id":"10202154","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"9235919","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"12914934","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"(3S)-3-hydroxyasparagine","evidences":[{"source":"PubMed","id":"12080085","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
