1KO9
Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006285 | biological_process | base-excision repair, AP site formation |
| A | 0006289 | biological_process | nucleotide-excision repair |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006974 | biological_process | DNA damage response |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0008534 | molecular_function | oxidized purine nucleobase lesion DNA N-glycosylase activity |
| A | 0009314 | biological_process | response to radiation |
| A | 0016363 | cellular_component | nuclear matrix |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0032357 | molecular_function | oxidized purine DNA binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034039 | molecular_function | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| A | 0034614 | biological_process | cellular response to reactive oxygen species |
| A | 0044029 | biological_process | positive regulation of gene expression via chromosomal CpG island demethylation |
| A | 0045007 | biological_process | depurination |
| A | 0045008 | biological_process | depyrimidination |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0140078 | molecular_function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
| A | 1901291 | biological_process | negative regulation of double-strand break repair via single-strand annealing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 400 |
| Chain | Residue |
| A | SER147 |
| A | SER148 |
| A | PRO168 |
| A | ARG169 |
| A | ARG204 |
| A | HOH622 |
| A | HOH718 |
| A | HOH732 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 600 |
| Chain | Residue |
| A | GLU70 |
| A | GLU71 |
| A | GLN72 |
| A | GLY308 |
| A | PRO309 |
| A | HOH684 |
| A | THR69 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"9197244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10706276","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11902834","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12578369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12592398","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15610848","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2abk |
| Chain | Residue | Details |
| A | LYS249 | |
| A | VAL267 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2abk |
| Chain | Residue | Details |
| A | LYS249 | |
| A | ASP268 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 185 |
| Chain | Residue | Details |
| A | LYS249 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | ASP268 | electrostatic stabiliser, hydrogen bond acceptor |
