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1KO9

Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003824molecular_functioncatalytic activity
A0004519molecular_functionendonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006285biological_processbase-excision repair, AP site formation
A0006289biological_processnucleotide-excision repair
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0006979biological_processresponse to oxidative stress
A0008017molecular_functionmicrotubule binding
A0008152biological_processmetabolic process
A0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
A0009314biological_processresponse to radiation
A0009410biological_processresponse to xenobiotic stimulus
A0009416biological_processresponse to light stimulus
A0016363cellular_componentnuclear matrix
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016829molecular_functionlyase activity
A0019104molecular_functionDNA N-glycosylase activity
A0019899molecular_functionenzyme binding
A0032355biological_processresponse to estradiol
A0032357molecular_functionoxidized purine DNA binding
A0032991cellular_componentprotein-containing complex
A0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
A0034614biological_processcellular response to reactive oxygen species
A0043066biological_processnegative regulation of apoptotic process
A0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
A0045007biological_processdepurination
A0045008biological_processdepyrimidination
A0045471biological_processresponse to ethanol
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051593biological_processresponse to folic acid
A0071276biological_processcellular response to cadmium ion
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0140097molecular_functioncatalytic activity, acting on DNA
A1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 400
ChainResidue
ASER147
ASER148
APRO168
AARG169
AARG204
AHOH622
AHOH718
AHOH732

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 600
ChainResidue
AGLU70
AGLU71
AGLN72
AGLY308
APRO309
AHOH684
ATHR69

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:9197244
ChainResidueDetails
ALYS249

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:10706276, ECO:0000269|PubMed:11902834, ECO:0000269|PubMed:12578369, ECO:0000269|PubMed:12592398, ECO:0000269|PubMed:15610848
ChainResidueDetails
AASN149
AARG154
AARG204
AHIS270
AGLN287

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING:
ChainResidueDetails
APRO266
AASP268
AGLN315
APHE319

Catalytic Information from CSA
site_idMCSA1
Number of Residues2
DetailsM-CSA 185
ChainResidueDetails
ALYS249covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
AASP268electrostatic stabiliser, hydrogen bond acceptor

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PDB entries from 2024-04-24

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