Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 996 |
| Chain | Residue |
| A | ASP137 |
| A | GLY169 |
| A | GLY171 |
| A | ASP173 |
| A | HOH1078 |
| A | HOH1085 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 997 |
| Chain | Residue |
| A | ILE159 |
| A | ASP177 |
| A | GLU180 |
| A | ASP154 |
| A | GLY155 |
| A | ASN157 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 998 |
| Chain | Residue |
| A | HIS147 |
| A | ASP149 |
| A | HIS162 |
| A | HIS175 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 999 |
| Chain | Residue |
| A | HLE1 |
| A | HIS197 |
| A | HIS201 |
| A | HIS207 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 996 |
| Chain | Residue |
| B | ASP137 |
| B | GLY169 |
| B | GLY171 |
| B | ASP173 |
| B | HOH1023 |
| B | HOH1024 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 997 |
| Chain | Residue |
| B | ASP154 |
| B | GLY155 |
| B | ASN157 |
| B | ILE159 |
| B | ASP177 |
| B | GLU180 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 998 |
| Chain | Residue |
| B | HIS147 |
| B | ASP149 |
| B | HIS162 |
| B | HIS175 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 999 |
| Chain | Residue |
| B | HLE1 |
| B | HIS197 |
| B | HIS201 |
| B | HIS207 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE HLE A 1 |
| Chain | Residue |
| A | RIN2 |
| A | ILE159 |
| A | LEU160 |
| A | ALA161 |
| A | HIS197 |
| A | GLU198 |
| A | HIS201 |
| A | HIS207 |
| A | PRO217 |
| A | ZN999 |
| A | HOH1033 |
| A | HOH1059 |
| A | HOH1194 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE RIN A 2 |
| Chain | Residue |
| A | HLE1 |
| A | GLN144 |
| A | GLY158 |
| A | LEU160 |
| A | TYR189 |
| A | PRO217 |
| A | ASN218 |
| A | TYR219 |
| A | HOH1021 |
| site_id | BC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE HLE B 1 |
| Chain | Residue |
| A | ASN150 |
| A | HOH1127 |
| B | RIN2 |
| B | ILE159 |
| B | LEU160 |
| B | ALA161 |
| B | HIS197 |
| B | GLU198 |
| B | HIS201 |
| B | HIS207 |
| B | PRO217 |
| B | ZN999 |
| B | HOH1015 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE RIN B 2 |
| Chain | Residue |
| A | ILE170 |
| B | HLE1 |
| B | GLY158 |
| B | PRO217 |
| B | ASN218 |
| B | TYR219 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL194-LEU203 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8137810","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | MET215 | |
| A | GLU198 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | MET215 | |
| B | GLU198 | |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU198 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU198 | |
