Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1K54

OXA-10 class D beta-lactamase partially acylated with reacted 6beta-(1-hydroxy-1-methylethyl) penicillanic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0042597	cellular_component	periplasmic space
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 901

Chain	Residue
B	LYS95
C	SER67
C	THR206
C	GLY207
C	PHE208
C	ARG250
C	SO4902
C	HOH926

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 902

Chain	Residue
C	LYS70
C	SER115
C	ALA116
C	VAL117
C	SO4901
C	HOH926
C	SER67

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 903

Chain	Residue
A	THR206
A	ARG250
A	LYS251
A	SO4905
A	HOH1018

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 904

Chain	Residue
C	LYS61
C	HOH936

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 905

Chain	Residue
A	SER67
A	SER115
A	LYS205
A	THR206
A	GLY207
A	PHE208
A	ARG250
A	SO4903
A	HOQ967

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 906

Chain	Residue
A	MET99
A	LYS100
A	GLN101

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 907

Chain	Residue
B	LYS152
C	THR213
C	ASN216
C	HOH965

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B 908

Chain	Residue
B	SER67
B	SER115
B	LYS205
B	THR206
B	GLY207
B	PHE208
B	ARG250
B	SO4909
B	HOQ967
B	HOH1082

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 909

Chain	Residue
B	THR206
B	ARG250
B	LYS251
B	SO4908
B	HOH1082
B	HOH1233

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 910

Chain	Residue
D	ARG250
D	LYS251
D	HOH1091
D	HOH1125
D	HOH1242

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 911

Chain	Residue
D	SER67
D	LYS70
D	SER115
D	ALA116
D	VAL117
D	HOH1118
D	HOH1197

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 912

Chain	Residue
B	MET99
B	LYS100
B	GLN101
B	HOH1232

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 913

Chain	Residue
B	THR80
B	ARG131
B	LYS134
B	TYR135
B	HOH1118

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 914

Chain	Residue
A	ARG131
A	LYS134
A	TYR135

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 915

Chain	Residue
B	ARG160

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 916

Chain	Residue
B	HOH1192
D	SER181
D	LYS182
D	HOH1065

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 917

Chain	Residue
A	LYS95
D	THR206
D	GLY207
D	PHE208
D	ARG250
D	HOH1152

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HOQ A 967

Chain	Residue
A	HOH1131
A	HOH1140
A	ALA66
A	SER67
A	KCX70
A	MET99
A	TRP102
A	VAL117
A	LEU155
A	GLY207
A	PHE208
A	SO4905

site_id	CC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HOQ B 967

Chain	Residue
B	ALA66
B	SER67
B	KCX70
B	MET99
B	TRP102
B	VAL117
B	GLY207
B	PHE208
B	SO4908
B	HOH1120

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1001

Chain	Residue
A	THR107
A	ARG109
A	HOH1004
A	HOH1052
A	HOH1110
C	GLU199
C	GLU227
C	GLU229

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1002

Chain	Residue
A	GLU199
A	GLU227
A	GLU229
A	HOH1057
A	HOH1113
C	THR107
C	ARG109

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 1003

Chain	Residue
B	GLU199
B	GLU229
B	HOH1020
B	HOH1078
D	THR107

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 1004

Chain	Residue
B	ASN38
B	ASP240
B	ASP242
B	HOH1015
B	HOH1022
B	HOH1129

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 1005

Chain	Residue
B	THR107
D	GLU199
D	GLU229
D	HOH1009

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
A	PRO65-ILE75
C	PRO65-ILE75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
A	SER67

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
B	SER67

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
C	SER67

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
D	SER67

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)