1JTY

Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ET A 205

Chain	Residue
A	GLN96
A	ILE99
A	ILE100
A	TYR103
A	GLU120
A	TYR123
A	ASN157
B	PHE162

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 299

Chain	Residue
A	TYR41
A	HIS42
A	LYS4

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 899

Chain	Residue
E	TYR20
E	LYS46
E	GLU47
E	GLU105
E	TYR106

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 195

Chain	Residue
D	THR24
D	GLY26
D	GLU27

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 900

Chain	Residue
E	LYS36
E	TYR40
E	THR45
E	LYS46
E	GLU47

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 699

Chain	Residue
A	THR24
A	GLY26
A	HOH811

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 999

Chain	Residue
D	ASN2
D	ASP5
D	LYS6

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 195

Chain	Residue
B	HIS128
B	LYS132
D	TYR41

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 399

Chain	Residue
E	LYS12
E	ILE56
E	GLU57
E	LYS60

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 799

Chain	Residue
A	THR25
A	LEU39
A	TYR40
A	LYS44
A	THR45

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 901

Chain	Residue
E	LYS4
E	HIS42

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 199

Chain	Residue
B	LYS60
B	TYR91
D	LYS67

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 499

Chain	Residue
A	ILE142
A	ASN143
A	ASP144
B	LYS177

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1000

Chain	Residue
B	GLN64
B	LYS67
B	TYR91
D	GLU90
D	TYR91

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 800

Chain	Residue
A	HIS128
A	VAL145
A	ASN146

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 801

Chain	Residue
A	LEU3
A	LYS4
A	HIS42

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 902

Chain	Residue
E	HIS128
E	LYS132
E	HOH913

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 802

Chain	Residue
A	SER35
A	LYS36
E	LYS60
E	TYR91

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L

Chain	Residue	Details
B	GLY19-LEU49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
B	THR24-PHE43
D	THR24-PHE43
A	THR24-PHE43
E	THR24-PHE43

---