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1JT7

Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001759biological_processorgan induction
A0001934biological_processpositive regulation of protein phosphorylation
A0005104molecular_functionfibroblast growth factor receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0008201molecular_functionheparin binding
A0008284biological_processpositive regulation of cell population proliferation
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009653biological_processanatomical structure morphogenesis
A0009887biological_processanimal organ morphogenesis
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0030154biological_processcell differentiation
A0030324biological_processlung development
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0030544molecular_functionHsp70 protein binding
A0031012cellular_componentextracellular matrix
A0032148biological_processactivation of protein kinase B activity
A0034605biological_processcellular response to heat
A0042060biological_processwound healing
A0043406biological_processpositive regulation of MAP kinase activity
A0044548molecular_functionS100 protein binding
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045766biological_processpositive regulation of angiogenesis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051781biological_processpositive regulation of cell division
A0060681biological_processbranch elongation involved in ureteric bud branching
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072163biological_processmesonephric epithelium development
A1901509biological_processregulation of endothelial tube morphogenesis
A1902533biological_processpositive regulation of intracellular signal transduction
A1903672biological_processpositive regulation of sprouting angiogenesis
A2000347biological_processpositive regulation of hepatocyte proliferation
A2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
B0001525biological_processangiogenesis
B0001759biological_processorgan induction
B0001934biological_processpositive regulation of protein phosphorylation
B0005104molecular_functionfibroblast growth factor receptor binding
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005938cellular_componentcell cortex
B0007165biological_processsignal transduction
B0008083molecular_functiongrowth factor activity
B0008201molecular_functionheparin binding
B0008284biological_processpositive regulation of cell population proliferation
B0008543biological_processfibroblast growth factor receptor signaling pathway
B0009653biological_processanatomical structure morphogenesis
B0009887biological_processanimal organ morphogenesis
B0010595biological_processpositive regulation of endothelial cell migration
B0010628biological_processpositive regulation of gene expression
B0030154biological_processcell differentiation
B0030324biological_processlung development
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0030544molecular_functionHsp70 protein binding
B0031012cellular_componentextracellular matrix
B0032148biological_processactivation of protein kinase B activity
B0034605biological_processcellular response to heat
B0042060biological_processwound healing
B0043406biological_processpositive regulation of MAP kinase activity
B0044548molecular_functionS100 protein binding
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0045766biological_processpositive regulation of angiogenesis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050673biological_processepithelial cell proliferation
B0050679biological_processpositive regulation of epithelial cell proliferation
B0051781biological_processpositive regulation of cell division
B0060681biological_processbranch elongation involved in ureteric bud branching
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0072163biological_processmesonephric epithelium development
B1901509biological_processregulation of endothelial tube morphogenesis
B1902533biological_processpositive regulation of intracellular signal transduction
B1903672biological_processpositive regulation of sprouting angiogenesis
B2000347biological_processpositive regulation of hepatocyte proliferation
B2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
C0001525biological_processangiogenesis
C0001759biological_processorgan induction
C0001934biological_processpositive regulation of protein phosphorylation
C0005104molecular_functionfibroblast growth factor receptor binding
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005938cellular_componentcell cortex
C0007165biological_processsignal transduction
C0008083molecular_functiongrowth factor activity
C0008201molecular_functionheparin binding
C0008284biological_processpositive regulation of cell population proliferation
C0008543biological_processfibroblast growth factor receptor signaling pathway
C0009653biological_processanatomical structure morphogenesis
C0009887biological_processanimal organ morphogenesis
C0010595biological_processpositive regulation of endothelial cell migration
C0010628biological_processpositive regulation of gene expression
C0030154biological_processcell differentiation
C0030324biological_processlung development
C0030334biological_processregulation of cell migration
C0030335biological_processpositive regulation of cell migration
C0030544molecular_functionHsp70 protein binding
C0031012cellular_componentextracellular matrix
C0032148biological_processactivation of protein kinase B activity
C0034605biological_processcellular response to heat
C0042060biological_processwound healing
C0043406biological_processpositive regulation of MAP kinase activity
C0044548molecular_functionS100 protein binding
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0045766biological_processpositive regulation of angiogenesis
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0050673biological_processepithelial cell proliferation
C0050679biological_processpositive regulation of epithelial cell proliferation
C0051781biological_processpositive regulation of cell division
C0060681biological_processbranch elongation involved in ureteric bud branching
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0072163biological_processmesonephric epithelium development
C1901509biological_processregulation of endothelial tube morphogenesis
C1902533biological_processpositive regulation of intracellular signal transduction
C1903672biological_processpositive regulation of sprouting angiogenesis
C2000347biological_processpositive regulation of hepatocyte proliferation
C2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
D0001525biological_processangiogenesis
D0001759biological_processorgan induction
D0001934biological_processpositive regulation of protein phosphorylation
D0005104molecular_functionfibroblast growth factor receptor binding
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005938cellular_componentcell cortex
D0007165biological_processsignal transduction
D0008083molecular_functiongrowth factor activity
D0008201molecular_functionheparin binding
D0008284biological_processpositive regulation of cell population proliferation
D0008543biological_processfibroblast growth factor receptor signaling pathway
D0009653biological_processanatomical structure morphogenesis
D0009887biological_processanimal organ morphogenesis
D0010595biological_processpositive regulation of endothelial cell migration
D0010628biological_processpositive regulation of gene expression
D0030154biological_processcell differentiation
D0030324biological_processlung development
D0030334biological_processregulation of cell migration
D0030335biological_processpositive regulation of cell migration
D0030544molecular_functionHsp70 protein binding
D0031012cellular_componentextracellular matrix
D0032148biological_processactivation of protein kinase B activity
D0034605biological_processcellular response to heat
D0042060biological_processwound healing
D0043406biological_processpositive regulation of MAP kinase activity
D0044548molecular_functionS100 protein binding
D0045542biological_processpositive regulation of cholesterol biosynthetic process
D0045766biological_processpositive regulation of angiogenesis
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0050673biological_processepithelial cell proliferation
D0050679biological_processpositive regulation of epithelial cell proliferation
D0051781biological_processpositive regulation of cell division
D0060681biological_processbranch elongation involved in ureteric bud branching
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0072163biological_processmesonephric epithelium development
D1901509biological_processregulation of endothelial tube morphogenesis
D1902533biological_processpositive regulation of intracellular signal transduction
D1903672biological_processpositive regulation of sprouting angiogenesis
D2000347biological_processpositive regulation of hepatocyte proliferation
D2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 160
ChainResidue
AASN18
ALYS112
ALYS113
ALYS118
AHOH313
BASP70

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE FMT A 164
ChainResidue
AHOH235
AHIS1
AHIS1
AHIS1

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 161
ChainResidue
BASN18
BLYS112
BLYS113
BHOH1446

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 C 162
ChainResidue
CASN18
CLYS112
CLYS113
CHOH2313
DASP70

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FMT C 165
ChainResidue
CHIS1
CHIS1
CHIS1
CLEU86
CHOH2235

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 D 163
ChainResidue
DASN18
DLYS112
DLYS113
DHOH3270
DHOH3446

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11069186, ECO:0000269|PubMed:9655399
ChainResidueDetails
AASN18
BASN18
CASN18
DASN18

222624

PDB entries from 2024-07-17

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