1J7E

A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0005499	molecular_function	vitamin D binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0031667	biological_process	response to nutrient levels
A	0035461	biological_process	vitamin transmembrane transport
A	0042359	biological_process	vitamin D metabolic process
A	0043202	cellular_component	lysosomal lumen
A	0051180	biological_process	vitamin transport
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	0090482	molecular_function	vitamin transmembrane transporter activity
A	0140104	molecular_function	molecular carrier activity
A	1902118	molecular_function	calcidiol binding
B	0003779	molecular_function	actin binding
B	0005499	molecular_function	vitamin D binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0031667	biological_process	response to nutrient levels
B	0035461	biological_process	vitamin transmembrane transport
B	0042359	biological_process	vitamin D metabolic process
B	0043202	cellular_component	lysosomal lumen
B	0051180	biological_process	vitamin transport
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
B	0090482	molecular_function	vitamin transmembrane transporter activity
B	0140104	molecular_function	molecular carrier activity
B	1902118	molecular_function	calcidiol binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE JY A 501

Chain	Residue
A	GLU8
A	SER79
A	MET107
A	HOH521
B	ASP364
B	THR367
A	VAL12
A	GLU15
A	SER28
A	LEU31
A	TYR32
A	LYS35
A	LEU75
A	SER76

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE JY B 502

Chain	Residue
B	GLU8
B	GLU15
B	LEU27
B	SER28
B	TYR32
B	PHE36
B	LEU47
B	TYR68
B	SER76
B	SER79
B	MET107

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLA A 502

Chain	Residue
A	VAL348
A	GLU350
A	PRO351
A	LYS354
A	GLU379
A	PHE383
A	ASP451

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OLA B 503

Chain	Residue
B	GLU379

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLA B 504

Chain	Residue
A	ASP361
B	ALA208
B	ALA209
B	TYR210
B	LYS214
B	LEU444

---

Functional Information from PROSITE/UniProt

site_id	PS00212
Number of Residues	25
Details	ALBUMIN_1 Albumin domain signature. YlsmvgsCCtsAsptvCFlkerlqL

Chain	Residue	Details
A	TYR166-LEU190

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Domain: {"description":"Albumin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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