1IHT

CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACE I 0

Chain	Residue
H	GLY216
I	DPN1

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DPN I 1

Chain	Residue
I	PRO2
H	GLU97
H	TRP215
H	GLY216
I	ACE0

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PTL I 4A

Chain	Residue
H	LEU41
H	LYS60
H	SER195
I	PRO2
I	FBE5

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FBE I 5

Chain	Residue
H	GLU39
H	LEU40
H	LEU41
H	GLY193
H	HOH560

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FBE I 6

Chain	Residue
I	FBE5
I	HOH558

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR CHAIN I OF HIRUTONIN-6

Chain	Residue
H	PHE34
H	GLN38
H	LEU40
H	LEU65
H	ARG67
H	ARG73
H	THR74
H	ARG75
H	ARG75
H	TYR76
H	HOH484
I	HOH558
I	HOH565

---

site_id	ACT
Number of Residues	3
Details	ACTIVE SITE

Chain	Residue
H	HIS57
H	ASP102
H	SER195

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
H	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923

Chain	Residue	Details
H	ASN60

---