1HPT
THREE-DIMENSIONAL STRUCTURE OF A RECOMBINANT VARIANT OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0007263 | biological_process | nitric oxide mediated signal transduction |
| A | 0010751 | biological_process | negative regulation of nitric oxide mediated signal transduction |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0048240 | biological_process | sperm capacitation |
| A | 0060046 | biological_process | regulation of acrosome reaction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090281 | biological_process | negative regulation of calcium ion import |
| A | 2001256 | biological_process | regulation of store-operated calcium entry |
Functional Information from PROSITE/UniProt
| site_id | PS00282 |
| Number of Residues | 23 |
| Details | KAZAL_1 Kazal serine protease inhibitors family signature. CtyeyRpvCgTdgdtYpneCvl.C |
| Chain | Residue | Details |
| A | CYS16-CYS38 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Reactive bond for trypsin => ECO:0000250|UniProtKB:P09036, ECO:0000255|PROSITE-ProRule:PRU00798 |
| Chain | Residue | Details |
| A | TYR18 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Necessary for sperm binding => ECO:0000250|UniProtKB:P09036 |
| Chain | Residue | Details |
| A | TYR20 |
