1GQF

Crystal structure of human procaspase-7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1403

Chain	Residue
A	ARG179
A	PRO335

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1403

Chain	Residue
B	PRO335
B	GLY336

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1404

Chain	Residue
B	LYS191
B	LYS171
B	GLY181
B	THR182
B	ASP183
B	LYS184

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1405

Chain	Residue
B	ARG345
B	TRP348

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1406

Chain	Residue
B	LYS171
B	ASP183
B	LYS191
B	ARG194

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Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HtnaaCfaCiLLSHG

Chain	Residue	Details
A	HIS224-GLY238

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:15314233

Chain	Residue	Details
A	HIS237
B	HIS237

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16916640

Chain	Residue	Details
A	ALA285
B	ALA285

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by CAPN1 => ECO:0000269|PubMed:19617626

Chain	Residue	Details
A	SER140
B	SER140

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site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Involved in allosteric regulation => ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:19581639

Chain	Residue	Details
A	ARG286
A	TYR331
B	ARG286
B	TYR331

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:27889207

Chain	Residue	Details
A	THR272
B	THR272

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120

Chain	Residue	Details
A	ARG341
B	ARG341

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:27889207

Chain	Residue	Details
A	SER347
B	SER347

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