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1GOT

HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000035molecular_functionacyl binding
A0001664molecular_functionG protein-coupled receptor binding
A0001750cellular_componentphotoreceptor outer segment
A0001917cellular_componentphotoreceptor inner segment
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005834cellular_componentheterotrimeric G-protein complex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007601biological_processvisual perception
A0007602biological_processphototransduction
A0007603biological_processphototransduction, visible light
A0009416biological_processresponse to light stimulus
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0019901molecular_functionprotein kinase binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0042622cellular_componentphotoreceptor outer segment membrane
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0050908biological_processdetection of light stimulus involved in visual perception
A0051344biological_processnegative regulation of cyclic-nucleotide phosphodiesterase activity
A0097381cellular_componentphotoreceptor disc membrane
A0097648cellular_componentG protein-coupled receptor complex
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
G0005834cellular_componentheterotrimeric G-protein complex
G0007186biological_processG protein-coupled receptor signaling pathway
G0031681molecular_functionG-protein beta-subunit binding
Functional Information from PDB Data
site_idAC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GDP G 355
ChainResidue
AGLY38
ALEU171
AARG172
AARG174
AASN265
ALYS266
AASP268
ALEU269
ACYS321
AALA322
ATHR323
AGLU39
AHOH369
AHOH563
GHOH358
GHOH359
GHOH367
ASER40
AGLY41
ALYS42
ASER43
ATHR44
AASP146
ASER147

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62873
ChainResidueDetails
BSER2
ASER147
AARG172

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphohistidine => ECO:0000269|PubMed:12486123
ChainResidueDetails
BHIS266
ATHR178

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND
ChainResidueDetails
AGLN200
ATHR323

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND
ChainResidueDetails
ALYS266

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P11488
ChainResidueDetails
AGLN143

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:1436039
ChainResidueDetails
AALA3

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
ATHR177
AGLN200
AGLU39
AARG174

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN200

222624

PDB entries from 2024-07-17

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