1G6I
Crystal structure of the yeast alpha-1,2-mannosidase with bound 1-deoxymannojirimycin at 1.59 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004559 | molecular_function | alpha-mannosidase activity |
A | 0004571 | molecular_function | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006486 | biological_process | protein glycosylation |
A | 0016020 | cellular_component | membrane |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0036503 | biological_process | ERAD pathway |
A | 0046872 | molecular_function | metal ion binding |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | MET0-SER3 |
site_id | SWS_FT_FI2 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
Chain | Residue | Details |
A | VAL4-TRP23 |
site_id | SWS_FT_FI3 |
Number of Residues | 329 |
Details | TOPO_DOM: Lumenal => ECO:0000255 |
Chain | Residue | Details |
A | TYR24-GLY353 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P31723 |
Chain | Residue | Details |
A | ASN404 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10675327 |
Chain | Residue | Details |
A | PHE530 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.7, ECO:0007744|PDB:1G6I |
Chain | Residue | Details |
A | ASN96 | |
A | ASN155 | |
A | ASN224 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dl2 |
Chain | Residue | Details |
A | ARG136 | |
A | GLU435 | |
A | ASP275 | |
A | GLU132 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 19 |
Chain | Residue | Details |
A | GLU132 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | ARG136 | activator, electrostatic stabiliser, hydrogen bond donor |
A | ASP275 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | ILE440 | activator |